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Publikováno v:
CNS & Neurological Disorders - Drug Targets. 21:108-117
Abstract:: Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement
Publikováno v:
Current Pharmaceutical Design. 27:4179-4185
Background: Berberine (BBR) is an isoquinoline alkaloid extracted from the Chinese medicine, exerting a variety of pharmacological effects. BBR is partially metabolized by cytochrome 3A4 (CYP3A4) in vivo. Some reports indicated that BBR could inhibit
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:1183-1195
Background Despite the evidence that plants do not possess sessile cells, they are able to mount a vigorous immune response against invaders or under stressful conditions. Mechanisms of action: Plants are endowed with pattern recognition receptors (P
Publikováno v:
Current Protein & Peptide Science. 22:479-492
The current meta-analysis of the cohort review was designed to elucidate the progress made in neuroproteomics of the synaptosome. The association of the comprehensive synaptic proteome and its link to physiological or pathological setting is rapidly
Autor:
Faheem Hyder Pottoo, Pooja Chawla, Sadat Shafi, Faizana Fayaz, Anjali Sharma, Archu Singh, Paras Gupta
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 20:54-67
Neurodegenerative diseases, including Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Huntington's Disease (HD), are characterized by progressive neuronal dysfunction and death. Recent studies have esta
Publikováno v:
Current Cancer Drug Targets. 21:91-106
Matrix metalloproteinases (MMPs) are a group of zinc-dependent metalloendopeptidases that are responsible for the degradation, repair, and remodeling of extracellular matrix components. MMPs play an important role in maintaining a normal physiologica
Autor:
Michael D. Dennis, Sadie K. Dierschke
Publikováno v:
Curr Diabetes Rev
Abstract:: It is well established that diabetes and its associated hyperglycemia negatively impacts retinal function, yet we know little about the role played by augmented flux through the hexosamine biosynthetic pathway (HBP). This offshoot of the g
Autor:
Shigeo Ohta
Publikováno v:
Current Pharmaceutical Design. 27:595-609
Molecular hydrogen (H2) was long regarded as non-functional in mammalian cells. We overturned the concept by demonstrating that H2 exhibits antioxidant effects and protects cells against oxidative stress. Subsequently, it has been revealed that H2 ha
Publikováno v:
Current Protein & Peptide Science. 21:1103-1142
Topoisomerases are reported to resolve the topological problems of DNA during several cellular processes, such as DNA replication, transcription, recombination, and chromatin remodeling. Two types of topoisomerases (Topo I and II) accomplish their de
Autor:
Sweta Bawari, Samira Shirooie, Archana N. Sah, Rosa Anna Vacca, Ahmad Reza Dehpour, Seyed Fazel Nabavi, Bernd L. Fiebich, Devesh Tewari, Nady Braidy, Seyed Mohammad Nabavi
Publikováno v:
Current Neuropharmacology
Current neuropharmacology 19 (2021): 114–126. doi:10.2174/1570159X18666200429001549
info:cnr-pdr/source/autori:Tewari D, Sah AN, Bawari S, Nabavi SF, Dehpour AR, Shirooie S, Braidy N, Fiebich BL, Vacca RA, Nabavi SM./titolo:Role of Nitric Oxide in Neurodegeneration: Function, Regulation and Inhibition/doi:10.2174%2F1570159X18666200429001549/rivista:Current neuropharmacology/anno:2021/pagina_da:114/pagina_a:126/intervallo_pagine:114–126/volume:19
Current neuropharmacology 19 (2021): 114–126. doi:10.2174/1570159X18666200429001549
info:cnr-pdr/source/autori:Tewari D, Sah AN, Bawari S, Nabavi SF, Dehpour AR, Shirooie S, Braidy N, Fiebich BL, Vacca RA, Nabavi SM./titolo:Role of Nitric Oxide in Neurodegeneration: Function, Regulation and Inhibition/doi:10.2174%2F1570159X18666200429001549/rivista:Current neuropharmacology/anno:2021/pagina_da:114/pagina_a:126/intervallo_pagine:114–126/volume:19
Reactive nitrogen species (RNS) and reactive oxygen species (ROS), collectively known as reactive oxygen and nitrogen species (RONS), are the products of normal cellular metabolism and interact with several vital biomolecules including nucleic acid,