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Publikováno v:
Current Protein & Peptide Science. 21:1103-1142
Topoisomerases are reported to resolve the topological problems of DNA during several cellular processes, such as DNA replication, transcription, recombination, and chromatin remodeling. Two types of topoisomerases (Topo I and II) accomplish their de
Publikováno v:
Current Protein & Peptide Science. 21:99-109
Butyrylcholinesterase is a serine hydrolase that catalyzes the hydrolysis of esters in the body. Unlike its sister enzyme acetylcholinesterase, butyrylcholinesterase has a broad substrate scope and lower acetylcholine catalytic efficiency. The differ
Publikováno v:
Current Protein & Peptide Science. 20:1218-1225
Out of multiple therapeutic targets, DPP-IV is the lead target for the treatment of type 2 diabetes. Natural products have always been available for the possible lead generation against various diseases and disorders. In the present review, we have c
Publikováno v:
Current Pharmaceutical Design. 25:2892-2905
Adenosine is a naturally occurring nucleoside and an essential component of the energy production and utilization systems of the body. Adenosine is formed by the degradation of adenosine-triphosphate (ATP) during energy-consuming processes. Adenosine
Autor:
Cong Tang, Guodong Zhu
Publikováno v:
Current Stem Cell Research & Therapy. 14:219-225
The nuclear factor kappa B (NF-κB) consists of a family of transcription factors involved in the regulation of a wide variety of biological responses. Growing evidence support that NF-κB plays a major role in oncogenesis as well as its well-known f
Publikováno v:
Current Neuropharmacology
G-protein coupled receptors are transmembrane proteins widely expressed in cells and their transduction pathways are mediated by controlling second messenger levels through different G-protein interactions. Many of these receptors have been described
Publikováno v:
Current Medicinal Chemistry. 25:346-354
Background: Various physiological and pathological stimuli can hypersensitize the sympathetic nervous system resulting in a substantial release of catecholamines (CA) and consequent alterations in excitation-contraction coupling and excitation-transc
Autor:
Nikita V. Dovidchenko, Oxana V. Galzitskaya, Mariya Yu. Suvorina, Olga M. Selivanova, Alexey K. Surin
Publikováno v:
Current Protein & Peptide Science. 18:57-64
There are different insulin analogues with various pharmacokinetic characteristics, such as, rapid-acting, long-acting, or intermediate-acting analogues. Since insulin tends to form amyloid aggregates, it is of particular interest to measure characte
Publikováno v:
Current Molecular Medicine. 16:487-495
Background: The accumulation of damaged or misfolded proteins in retinal pigment epithelial (RPE) cells was considered a contributing factor for RPE dysfunction in age-related macular degeneration (AMD). The ubiquitinproteasome pathway (UPP) and the
Autor:
Ping-Ping Lv, Peter C.K. Leung, X.-L. Hu, H.-J. Gao, J.-Y. Jiang, A.-X. Liu, Y.-M. Zhu, Dan Zhang, H.-F. Huang
Publikováno v:
Current Molecular Medicine. 16:299-311
Although GHRH and GHRH-R are recognized as key factors in placental development, little is known about the mechanism(s) of the regulation in trophoblastic cells during placental development. The objective of this study is to determine the potential r