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Publikováno v:
Current Molecular Medicine. 22:491-505
Exosomal vesicles enclose and carry a broad range of biological molecules, such as nucleic acids, lipids, and proteins, and transfer them between cells. In cancer, cells being mentioned could be neighbors in the same tumor microenvironment communicat
Autor:
Sukhes Mukherjee, Suman Kumar Ray
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1257-1271
Tissues are progressively molded by bidirectional correspondence between denizen cells and extracellular matrix (ECM) via cell-matrix connections along with ECM remodeling. The composition and association of ECM are spatiotemporally directed to contr
Publikováno v:
Current Protein & Peptide Science. 23:158-165
Abstract: Cancer is fundamentally a disease of perturbed genes. Although many mutations can be marked in the genome of cancer or a transformed cell, the initiation and progression are driven by only a few mutational events, viz., driver mutations tha
Autor:
Fatima Akram, Ikram ul Haq, Zuriat Jabbar, Rabia Akram, Ali Nawaz, Amna Aqeel, Noman Atique, Zeeshan Ahmed
Publikováno v:
Current Protein & Peptide Science. 22:599-619
Background: MicroRNAs (miRNA) belong to the substantial class of posttranscriptional gene regulators with decisive functions in typical cellular and disease progressions. They are short RNA molecules that are not translated into proteins but bind to
Publikováno v:
Current Medicinal Chemistry. 28:8480-8495
The oxidative stress response is critical for malignant cells. It plays a dual role by helping cancer cells survive and proliferate but also causing apoptosis and apoptosis-- like cell death. The oxidative stress response is characterized by tight re
Autor:
Angeles C. Tecalco-Cruz
Publikováno v:
Current Protein & Peptide Science. 22:19-28
Human interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 ha
Publikováno v:
Current Pharmaceutical Design. 26:5040-5053
Background:Toll like receptors (TLRs) are a group of transmembrane receptors belonging to the broad class pattern recognition receptors (PRR), involved in recognition of Pathogen Associated Molecular Patterns (PAMPs) thereby inducing an immune respon
Publikováno v:
Current Cancer Drug Targets. 20:741-756
Several subtypes of T cells are located in a tumor environment, each of which supplies their energy using different metabolic mechanisms. Since the cancer cells require high levels of glucose, the conditions of food poverty in the tumor environment c
Autor:
Davide Ciardiello, Vincenzo De Falco, Anna Procopio, Erika Martinelli, Vincenzo Famiglietti, Carmelina Loguercio, Giuseppe Gerardo Caprio, Emilio Francesco Giunta, Ludovico Abenavoli, Alessandro Federico, Antonietta Gerarda Gravina, Fortunato Ciardiello, Pietro P. Vitiello, Desiree Picascia, Marcello Dallio
Publikováno v:
Reviews on Recent Clinical Trials. 15:164-177
Background: In accordance with the scientific literature heavy alcohol consumption (>50g per day) represents a risk factor for several diseases development, including cancer. However, the oncogenic role of light alcohol drinking ( Objective: To asses
Publikováno v:
Current Protein & Peptide Science. 21:507-516
The retinoic acid (RA) signaling pathway is crucial for many biological processes. The RA transporter, Cellular Retinoic-Acid Binding Protein 2 (CRABP2), is abnormally expressed in various tumor types. CRABP2 presents significant effects on tumorous