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Publikováno v:
Current Protein & Peptide Science. 19:841-849
Breast cancer cases in women are increasing at an alarming rate globally and extensive research is being conducted to identify a breakthrough medicine against this dreadful disease. In fact, researchers are looking for fresh targets to develop novel
Publikováno v:
Current Protein & Peptide Science. 19:612-622
Clusterin is a multifunctional glycoprotein whose role in cells has generated a great controversy in recent years. Since its discovery, numerous studies have linked clusterin expression deregulation with various physio-pathological processes such as
Autor:
Chiharu Uchida, Masatoshi Kitagawa
Publikováno v:
Current Cancer Drug Targets. 16:157-174
In the ubiquitylation system, E3 ubiquitin ligases play a key role in determining substrate specificity and catalyzing the transfer of ubiquitin from E2 enzymes to the substrate. Growing evidence has shown that E3 ubiquitin ligases are involved in ca
Autor:
Kyoko Kitagawa, Masatoshi Kitagawa
Publikováno v:
Current Cancer Drug Targets. 16:119-129
The ubiquitin system controls protein stability and function. F-box proteins form SCF (SKP1-Cullin1-F-box protein)-type ubiquitin (E3) ligases to selectively target their substrates for degradation via the ubiquitin-proteasome pathway. Here, we revie
Regulation of Epithelial-Mesenchymal Transition by E3 Ubiquitin Ligases and Deubiquitinase in Cancer
Autor:
Takahito Tanaka, Chihiro Sumita, Hidetoshi Hayashi, Yasumichi Inoue, Fumihiro Kawasaki, Daisuke Morishita, Yuka Itoh, Koichi Sato
Publikováno v:
Current Cancer Drug Targets. 16:110-118
Epithelial-mesenchymal transition (EMT) plays an important role in the development of tumor metastases by facilitating cell migration and invasion. One of the hallmarks of EMT is the diminished expression of E-cadherin and gain of mesenchymal traits,
Publikováno v:
Current Protein & Peptide Science. 19
Cancer, characterized by uncontrolled growth and proliferation of cells, is affecting millions of people every year and estimated as the second leading cause of death. Its successful treatment yet remains a challenge due to the lack of selectivity, t
Publikováno v:
Current Pharmaceutical Design. 20:2849-2880
Tumor progression is strongly associated with the activity of receptor tyrosine kinases (RTKs) and their intracellular signal transduction pathways, which regulate several cell functions including proliferation, apoptosis, motility, adhesion and angi
Publikováno v:
Current Drug Targets. 14:1157-1166
The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest,
Autor:
Maria C. Pedroso de Lima, Carla P. Gomes, José S. Ramalho, Lígia C. Gomes-da-Silva, João Nuno Moreira, Sérgio Simões
Publikováno v:
Current Gene Therapy. 13:189-201
The main goal of this work was to assess in vitro the potential of Polo-like kinase gene (PLK-1) as a molecular target within the tumor microenvironment, namely in both cancer cells of tumors of different histological origin and endothelial cells fro
Autor:
Zhiwei Wang, Fazlul H. Sarkar, Wenyi Wei, Jiateng Zhong, Pengda Liu, Hiroyuki Inuzuka, Lixin Wan
Publikováno v:
Current Pharmaceutical Design. 19:3210-3214
The Anaphase Promoting Complex (APC) has been characterized to play pivotal roles in regulating the timely cell cycle progression by forming two functionally distinct E3 ubiquitin ligase sub-complexes, APC(Cdc20) and APC(Cdh1). Interestingly, recent