Zobrazeno 1 - 10
of 14
pro vyhledávání: ''
Publikováno v:
Current Protein & Peptide Science. 21:507-516
The retinoic acid (RA) signaling pathway is crucial for many biological processes. The RA transporter, Cellular Retinoic-Acid Binding Protein 2 (CRABP2), is abnormally expressed in various tumor types. CRABP2 presents significant effects on tumorous
Publikováno v:
Current Medicinal Chemistry. 23:2618-2636
Nitric Oxide (NO) is a signaling radical, highly diffusible pleiotropic regulator of a large set of different molecular and biological pathways, including, neurotransmission, vasodilatation and macrophagemediated responses against infections. It is p
Publikováno v:
Current Protein & Peptide Science. 19
It is an acknowledged fact that health benefits are derived from fruit- and vegetables-enriched diets. In particular, polyphenols, compounds bearing one or more hydroxyl groups attached to an aromatic ring, are ascribed for most of such beneficial ef
Autor:
Zhangfeng Zhong, Wen Tan, Xiao-Dong Hu, Xian Yang, Yitao Wang, Ning Li, Rui Tan, Zhan-Wei Suo
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 15:66-78
Berberine exerted anti-cancer effect in various cancer cell lines, and was also implied in the treatment of metabolic related diseases. Given the metabolic modulation, we hypothesized that berberine possessed anti-cancer effect under the assistance o
Autor:
Maria C. Pedroso de Lima, Carla P. Gomes, José S. Ramalho, Lígia C. Gomes-da-Silva, João Nuno Moreira, Sérgio Simões
Publikováno v:
Current Gene Therapy. 13:189-201
The main goal of this work was to assess in vitro the potential of Polo-like kinase gene (PLK-1) as a molecular target within the tumor microenvironment, namely in both cancer cells of tumors of different histological origin and endothelial cells fro
Publikováno v:
ResearcherID
Treatment of cancer is by no means universally successful and often manifests harmful side effects. The best way to improve the success rate and reduce the side effects would be to develop compounds that are able to kill cancer cells while leaving no
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scopus-Elsevier
instname
Scopus-Elsevier
Transformed cells suffer several changes leading to the increase of protective mechanisms and show a metabolic profile in accordance with higher proliferative capacity. In these mechanisms, changes in mitochondrial activity cause a higher glycolytic
Publikováno v:
ResearcherID
Sphingolipids, which are complex lipidic components of the cell membranes, lie in a key position to modulate the pathways of trans-membrane signaling and allow the cell to adapt to environmental stresses. In malignancies, reduced production of some s
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 11:911-919
The bioactive sphingolipid, ceramide, has garnered major interest as a principle regulator of cellular stress, proliferation, senescence, and death. Of particular interest to cancer biologists and clinical oncologist, dysregulated ceramide metabolism
Publikováno v:
ResearcherID
Sphingosine 1-phosphate (S1P) is a bioactive lipid with diverse biological functions, including cell proliferation, differentiation, angiogenesis, chemotaxis, and migration. Many of the activities of S1P are mediated through five closely related G-pr