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Autor:
Hiroyuki Saito, Yuki Takechi-Haraya
Publikováno v:
Current Protein & Peptide Science. 19:623-630
Arginine-rich cell penetrating peptides (CPPs) are very promising drug carriers to deliver membrane-impermeable pharmaceuticals, such as siRNA, bioactive peptides and proteins. CPPs directly penetrate into cells across cell membranes via a spontaneou
Autor:
Carlos H.I. Ramos, Júlio César Borges, Fernanda Aparecida Heleno Batista, Lisandra M. Gava, Glaucia M.S. Pinheiro
Publikováno v:
Current Protein & Peptide Science. 16:735-753
Proteins participate in almost every cell physiological function, and to do so, they need to reach a state that allows its function by folding and/or exposing surfaces of interactions. Spontaneous folding in the cell is in general hindered by its cro
Autor:
Ann R. Spevacek, Eric D. Walter, Andrew Dei Rossi, Micah P. Visconte, Daniel J. Stevens, Glenn L. Millhauser
Publikováno v:
Current Protein & Peptide Science. 10:529-535
Current research suggests that the function of the prion protein (PrP) is linked to its ability to bind copper. PrP is implicated in copper regulation, copper buffering and copper-dependent signaling. Moreover, in the development of prion disease, co
Autor:
Katherine L. B. Borden, Alex Kentsis
Publikováno v:
Current Protein and Peptide Science. 5:125-134
In living cells, chemical reactions of metabolism, information processing, growth and development are organized in a complex network of interactions. At least in part, the organization of this network is accomplished as a result of physical assembly
Autor:
Bruno O. Villoutreix
Publikováno v:
Current Protein and Peptide Science. 3:341-364
Structural and theoretical analyses of proteins are central to the understanding of complex molecular mechanisms and are fundamental to the drug discovery process. Computational techniques yield useful insights into an ever-wider range of biomolecula