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Publikováno v:
Current Stem Cell Research & Therapy. 16:980-993
Mesenchymal stem/stromal cells (MSCs) are adult multipotent cells with self-renewal potential and the ability to differentiate into specialized cells. MSCs home in various tissues and can be isolated using simple methods. Because of this feasibility
Autor:
Juan-Juan Li, Si-Yu Chen, Cheng Huang, Yu Chen, Ao Wang, Xiao-Feng Li, Sai Zhu, Jun Li, Xin Chen
Publikováno v:
Current Pharmaceutical Design. 27:3000-3011
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of targets genes by binding to the 3′-untranslated regions. They play vital roles in diverse biological processes, including the development of hepatic fibrosis (HF)
Publikováno v:
Current Medicinal Chemistry. 28:3647-3665
Kidney disease is a serious health problem that burdens our healthcare system. It is crucial to find the accurate pathogenesis of various types of kidney disease to provide guidance for precise therapies for patients suffering from these diseases. Ho
Publikováno v:
Protein & Peptide Letters. 28:382-387
Transmembrane protein 166 (TMEM166) is a lysosomal/endoplasmic reticulum (ER)-associated protein found in different species where it functions as a regulator of programmed cell death through autophagy and apoptosis. It is expressed in a variety of no
Publikováno v:
Protein & Peptide Letters. 28:414-425
Background: Human Papilloma Virus (HPV) is the primary cause of cancers in cervix, head and neck regions. Oncoprotein E6 of HPV-16, after infecting human body, alters host protein- protein interaction networks. E6 interacts with several proteins, cau
Autor:
Faheem Hyder Pottoo, Pooja Chawla, Sadat Shafi, Faizana Fayaz, Anjali Sharma, Archu Singh, Paras Gupta
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 20:54-67
Neurodegenerative diseases, including Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Huntington's Disease (HD), are characterized by progressive neuronal dysfunction and death. Recent studies have esta
Autor:
Atiqur Rahman, Shazid Md. Sharker
Publikováno v:
Current Drug Discovery Technologies. 18:354-364
Most of the clinical approved protein-based drugs or under clinical trials have a profound impact on the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly
Publikováno v:
Curr Protein Pept Sci
Neuropeptides are an important class of endogenous peptides in the nervous system that regulate physiological functions such as feeding, glucose homeostasis, pain, memory, reproduction, and many others. In order to understand the functional role of n
Publikováno v:
Current Stem Cell Research & Therapy. 16:243-261
Mesenchymal stromal cells (MSCs) regulate other cell types through a strong paracrine component called the secretome, comprising several bioactive entities. The composition of the MSCs’ secretome is dependent upon the microenvironment in which they
Publikováno v:
Current Gene Therapy. 21:112-129
Skeletal system has been considered a highly dynamic system, in which bone-forming osteoblasts and bone-resorbing osteoclasts go through a continuous remodeling cycle to maintain homeostasis of bone matrix. It has been well acknowledged that interfer