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Publikováno v:
Current Protein & Peptide Science. 20:1089-1101
Enzymes of the prolyl oligopeptidase family (S9 family) recognize their substrates not only by the specificity motif to be cleaved but also by size - they hydrolyze oligopeptides smaller than 30 amino acids. They belong to the serine-protease family,
Publikováno v:
Protein & Peptide Letters. 26:910-918
Background: Melanin plays a crucial role in camouflage, social communication and protection against harmful ultraviolet radiations. Melanin is synthesized by melanocytes through melanogenesis and several intrinsic and extrinsic factors are involved d
Autor:
Aaron M. Williams, Hasan B. Alam, Baoling Liu, Umar F. Bhatti, Yuzi Tian, Yongqing Li, Panpan Chang
Publikováno v:
Current Molecular Medicine. 19:673-682
Background: Histone deacetylase (HDAC) 6 inhibitors have demonstrated significant protective effects in traumatic injuries. However, their roles in neuroprotection and underlying mechanisms are poorly understood. This study sought to investigate the
Publikováno v:
Current Pharmaceutical Design. 25:2969-2974
Background: Osteoarthritis (OA) is a common joint disease characterized by cartilage degeneration. Long non-coding RNAs (lncRNAs) have been associated with inflammatory diseases, including OA. Here, we investigated the potential molecular role of lnc
Publikováno v:
Current Pharmaceutical Design. 25:2892-2905
Adenosine is a naturally occurring nucleoside and an essential component of the energy production and utilization systems of the body. Adenosine is formed by the degradation of adenosine-triphosphate (ATP) during energy-consuming processes. Adenosine
Publikováno v:
Current Pharmaceutical Design. 25:2584-2594
Mitochondria are the central power stations of the cell involved with a myriad of cell signalling pathways that contribute for whole health status of the cell. It is a well known fact that not only mitochondrial genome encodes for mitochondrial prote
Autor:
Wen Zhao, Ziyang Lian, Mingliang Jin, Junling Shi, Bobo Zhu, Dongyan Shao, Qingsheng Huang, Chuyuan Lei, Chunmei Jiang
Publikováno v:
Current Protein & Peptide Science. 20:1004-1011
Cardiovascular disease (CVD) is the biggest killer globally and atherosclerosis (AS) is the major trigger to this pathology. Abnormal cholesterol homeostasis is the starting point of AS, especially the aggregation of macrophage foam cells in the intr
Publikováno v:
Current Protein & Peptide Science. 20:984-995
Vitamin D, as a natural medicine, is known to regulate calcium and phosphate homeostasis. But abundant research has shown that vitamin D also plays a regulatory role in autoimmunity, inflammation, angiogenesis and vascular cell activity. Since the vi
Autor:
Evgeny S. Zhvansky, Daniil G. Ivanov, Alexander Potapov, Eugene N. Nikolaev, S. I. Pekov, Igor Popov, V A Shurkhay, Anatoly Sorokin, Eugene E. Kulikov
Publikováno v:
Current Topics in Medicinal Chemistry. 19:1521-1534
Cells metabolism alteration is the new hallmark of cancer, as well as an important method for carcinogenesis investigation. It is well known that the malignant cells switch to aerobic glycolysis pathway occurring also in healthy proliferating cells.
Publikováno v:
Current Protein & Peptide Science. 20:935-943
Secretory and membrane proteins are folded in the endoplasmic reticulum (ER) prior to their exit. When ER function is disturbed by exogenous and endogenous factors, such as heat shock, ultraviolet radiation, hypoxia, or hypoglycemia, the misfolded pr