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Autor:
Juan-Juan Li, Si-Yu Chen, Cheng Huang, Yu Chen, Ao Wang, Xiao-Feng Li, Sai Zhu, Jun Li, Xin Chen
Publikováno v:
Current Pharmaceutical Design. 27:3000-3011
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of targets genes by binding to the 3′-untranslated regions. They play vital roles in diverse biological processes, including the development of hepatic fibrosis (HF)
Publikováno v:
Current Gene Therapy. 21:112-129
Skeletal system has been considered a highly dynamic system, in which bone-forming osteoblasts and bone-resorbing osteoclasts go through a continuous remodeling cycle to maintain homeostasis of bone matrix. It has been well acknowledged that interfer
Autor:
Xin Sun, Qing Luo, Li Liang, Wei Liu, Huaichuan Duan, Jianping Hu, Xinyu Liu, Gang Zhao, Yichen Hu, Hua Wan, Lianxin Peng, Ya Gan, Hubing Shi
Publikováno v:
Current Protein & Peptide Science. 21:1027-1039
Indoleamine 2, 3-dioxygenase 1 (IDO1) is the only rate-limiting enzyme outside the liver that catalyzes the oxidation and cracking of indole rings in the tryptophan along the kynurenine pathway (KP). The overactivation of IDO1 is closely related to t
Publikováno v:
Current Drug Targets. 22:77-104
Bone is one of the dynamic tissues in the human body that undergoes continuous remodelling through subsequent actions of bone cells, osteoclasts, and osteoblasts. Several signal transduction pathways are involved in the transition of mesenchymal stem
Autor:
Sharath Belenahalli Shekarappa, Shivananda Kandagalla, Manjunatha Hanumanthappa, Umme Hani, Gollapalli Pavan
Publikováno v:
Current Drug Discovery Technologies. 17:647-660
Background: Capsaicin is an active alkaloid /principal component of red pepper responsible for the pungency of chili pepper. Capsaicin by changing the intracellular redox homeostasis regulate a variety of signaling pathways ultimately producing a div
Autor:
Arbab Husain, Alvina Farooqui, Afreen Khanam, Shahnawaz Rehman, Mohd Aslam Yusuf, Saheem Ahmad
Publikováno v:
Current Protein & Peptide Science. 21:899-915
The non-enzymatic interaction of sugar and protein resulting in the formation of advanced glycation end products responsible for cell signaling alterations ultimately leads to the human chronic disorders such as diabetes mellitus, cardiovascular dise
Publikováno v:
Protein & Peptide Letters. 27:1114-1123
Background: B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) can activate signaling pathways by binding to specific receptors. BR3 (BAFF receptor) shows a unique selectivity for BAFF ligand, while B-cell maturation antigen
Publikováno v:
Current Pharmaceutical Design. 26:5040-5053
Background:Toll like receptors (TLRs) are a group of transmembrane receptors belonging to the broad class pattern recognition receptors (PRR), involved in recognition of Pathogen Associated Molecular Patterns (PAMPs) thereby inducing an immune respon
Publikováno v:
Current Protein & Peptide Science. 21:761-765
Amino acids (AAs) and their metabolites regulate key metabolic pathways that are necessary for growth, reproduction, immunity and metabolism of the body. It has been convinced that metabolic diseases are closely related to disorders of glycolipid met
Publikováno v:
Current Protein & Peptide Science. 21:751-760
Heat shock proteins (HSPs) are molecular chaperones involved in a variety of life activities. HSPs function in the refolding of misfolded proteins, thereby contributing to the maintenance of cellular homeostasis. Heat shock factor (HSF) is activated