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Autor:
Joanne M. Bowen, Dorothy M. K. Keefe, Tingting Wang, Lorelle T Smith, David I. Watson, Tanya Irvine, George C. Mayne, Imogen A. Ball, Tim Bright, Karen Chiam, Sarah K. Thompson, Damian J. Hussey
Publikováno v:
World Journal of Gastroenterology
BACKGROUND Circulating microRNAs (miRNAs) are potential biomarkers for many diseases. However, they can originate from non-disease specific sources, such as blood cells, and compromise the investigations for miRNA biomarkers. While small extracellula
Publikováno v:
World Journal of Gastroenterology
BACKGROUND The incidence of colon cancer (CC) is currently high, and is mainly treated with chemotherapy. Oxaliplatin (L-OHP) is a commonly used drug in chemotherapy; however, long-term use can induce drug resistance and seriously affect the prognosi
Publikováno v:
World Journal of Gastroenterology
BACKGROUND Chronic constipation is a gastrointestinal functional disease that seriously harms physical and mental health and impacts the quality of life of patients. Its incidence rate is 2%-27%. Slow transit constipation (STC) is a common type of ch
Autor:
Tsan Yang, Chih-Hsiung Hsu, Chi-Hua Huang, Fu-Huang Lin, Chao-Yang Chen, Yu-Chan Liao, Chien-An Sun, Cheng-Wen Hsiao, Je-Ming Hu, Yu-Ching Chou, Wen-Chih Wu
Publikováno v:
World Journal of Gastroenterology
BACKGROUND It is evident that current clinical criteria are suboptimal to accurately estimate patient prognosis. Studies have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer (CRC). AIM To estimate whether a me
Publikováno v:
World Journal of Gastroenterology
BACKGROUND Gastric adenocarcinoma (GAC) mortality rates have remained relatively changed over the past 30 years, and it continues to be one of the leading causes of cancer-related death. AIM To search for novel miRNAs related to GAC prognosis and fur
Publikováno v:
World Journal of Gastroenterology
Background Highly upregulated in liver cancer (HULC) is a long non-coding RNA (lncRNA) which has recently been identified as a key regulator in hepatocellular carcinoma (HCC) progression. However, its role in the secretion of exosomes from HCC cells
Publikováno v:
World Journal of Gastroenterology
Background Pancreatic cancer is a deadly malignancy with aggressive properties. MicroRNAs (miRNAs) participate in the pathogenesis of a variety of diseases and molecular processes by targeting functional mRNAs. Nevertheless, the regulatory role of mi
Publikováno v:
World Journal of Gastroenterology
Background Gastric cancer (GC) is the fourth most frequent malignancy all over the world. The diagnosis of GC is challenging and the prognosis of GC is very unfavorable. Accumulating evidence reveals that serum long noncoding RNAs (lncRNAs) can funct
Publikováno v:
World Journal of Gastroenterology
Background The circular RNA circ-PRKCI is an endogenous non-coding RNA that forms a covalently closed ring after reverse splicing, which plays a key role in the occurrence and development of multiple digestive system tumors. Aim To investigate the ro
Autor:
Chang Jiang, Haohua Wang, Yi-Jun Zhang, Hui-Quan Qiu, Yixing Wang, Liangping Xia, Guifang Guo, Jia-Bin Lu, Xiuxing Chen
Publikováno v:
World Journal of Gastroenterology. 25:1840-1853
BACKGROUND Colorectal cancer (CRC) is one of the main causes of cancer-related deaths in China and around the world. Advanced CRC (ACRC) patients suffer from a low cure rate though treated with targeted therapies. The response rate is about 50% to ch