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Publikováno v:
World Journal of Gastroenterology
BACKGROUND Chronic constipation is a gastrointestinal functional disease that seriously harms physical and mental health and impacts the quality of life of patients. Its incidence rate is 2%-27%. Slow transit constipation (STC) is a common type of ch
Publikováno v:
World Journal of Gastroenterology
Background Pancreatic cancer is a deadly malignancy with aggressive properties. MicroRNAs (miRNAs) participate in the pathogenesis of a variety of diseases and molecular processes by targeting functional mRNAs. Nevertheless, the regulatory role of mi
Autor:
Chang Jiang, Haohua Wang, Yi-Jun Zhang, Hui-Quan Qiu, Yixing Wang, Liangping Xia, Guifang Guo, Jia-Bin Lu, Xiuxing Chen
Publikováno v:
World Journal of Gastroenterology. 25:1840-1853
BACKGROUND Colorectal cancer (CRC) is one of the main causes of cancer-related deaths in China and around the world. Advanced CRC (ACRC) patients suffer from a low cure rate though treated with targeted therapies. The response rate is about 50% to ch
Autor:
Patrícia Matos Biselli-Chicote, João Gomes Netinho, Eny Maria Goloni-Bertollo, Anelise Russo, Gabriela Helena Rodrigues-Fleming, Glaucia Maria de Mendonça Fernandes, Érika Cristina Pavarino
Publikováno v:
World Journal of Gastroenterology
AIM To evaluate the association between polymorphisms in glutathione S transferases (GSTs) and the risk of sporadic colorectal cancer (SCRC), tumor progression and the survival of patients. METHODS A case-control study of 970 individuals from the Bra
Autor:
Yunfei Xu, Bo Han, Hong Su, Yu-Bao Yang, Fu-Jun Ge, Ming-Hong Zhao, Xiaoqing Yang, An-Cheng Zhao, Jie Yang
Publikováno v:
World Journal of Gastroenterology. 21:3256-3265
AIM: To evaluate the prognostic value of high-mobility group box 1 (HMGB1) expression in intrahepatic cholangiocarcinoma (IHCC) and the possible underlying mechanism. METHODS: Tissue microarray was constructed from 65 IHCC patients. Immunohistochemis
Publikováno v:
World Journal of Gastroenterology
AIM To compare the expression levels of interleukin (IL)-6 in colorectal cancer (CRC) tissues and adjacent non-cancerous tissues, and analyse the correlation of IL-6 expression with the clinicopathological parameters of CRC. METHODS Fifty CRC tissue
Autor:
Stéphane Supiot, Wilfried Gouraud, Loïc Campion, Josiane Charrier, Bruno Buecher, Emmanuel Rio, Marc-André Mahé, Michel Chérel, Pascal Jézéquel, Marie-Françoise Heymann
Publikováno v:
World Journal of Gastroenterology. 19:3249
To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy.Six patients presenting with a locally advanced rectal cancer (TT2, N0/Nx, M0) eligible for preoper
Autor:
Ji Hyun Lee, Sung Yong Oh, Su Jin Kim, Suee Lee, Sunghyun Kim, Hyo-Jin Kim, Min Chan Kim, Ki Han Kim, Jin Seok Jang, Seong-Geun Kim, Hyuk-Chan Kwon
Publikováno v:
World Journal of Gastroenterology. 18:4744
AIM: To assess the prognostic significance of nuclear factor-κB (NF-κB) and its target genes in gastric cancer. METHODS: The tumor tissues of 115 patients with gastric cancer were immunohistochemically evaluated using monoclonal antibodies against
Autor:
Hirokazu Noshiro, Seiji Sato, Kohji Miyazaki, Yoshihiko Kitajima, Kazuyoshi Hashiguchi, Jun Nakamura, Masatsugu Hiraki
Publikováno v:
World Journal of Gastroenterology. 16:330
To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription fac
Autor:
Miao Zhen Qiu, Hui Zhong Zhang, Hui Yan Luo, Zhuang Hua Li, Rui-Hua Xu, Fang Hua Li, Lin Shen, Yu Hong Li
Publikováno v:
World Journal of Gastroenterology. 16:5881
AIM: To investigate the prognostic value of KRAS mutation, and phosphatase and tensin (PTEN) expression in Chinese metastatic colorectal cancer metastatic colorectal cancer (mCRC) patients treated with cetuximab. METHODS: Ninety Chinese mCRC patients