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Publikováno v:
Annual Review of Microbiology. 71:331-348
Evolution-related multisubunit RNA polymerases (RNAPs) carry out RNA synthesis in all domains life. Although their catalytic cores and fundamental mechanisms of transcription elongation are conserved, the initiation stage of the transcription cycle d
Publikováno v:
Nogales, E; Louder, RK; & He, Y. (2017). Structural Insights into the Eukaryotic Transcription Initiation Machinery. Annual Review of Biophysics, 46, 59-83. doi: 10.1146/annurev-biophys-070816-033751. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3b04q80f
Annual review of biophysics, vol 46, iss 1
Annual review of biophysics, vol 46, iss 1
© 2017 by Annual Reviews. All rights reserved. Eukaryotic gene transcription requires the assembly at the promoter of a large preinitiation complex (PIC) that includes RNA polymerase II (Pol II) and the general transcription factors TFIID, TFIIA, TF
Autor:
Ronald C. Conaway
Publikováno v:
Annual Review of Biochemistry. 87:23-25
Although cell metabolism has been established as a major regulator of eukaryotic gene expression, the mechanisms underlying this regulation are still being uncovered. Recent years have seen great advances in our understanding of biochemical mechanism
Publikováno v:
Annual Review of Microbiology. 69:49-69
Bacteria lack subcellular compartments and harbor a single RNA polymerase that synthesizes both structural and protein-coding RNAs, which are cotranscriptionally processed by distinct pathways. Nascent rRNAs fold into elaborate secondary structures a
Autor:
Karen M. Arndt, Daniel Reines
Publikováno v:
Annual Review of Biochemistry. 84:381-404
The RNA polymerase II transcription cycle is often divided into three major stages: initiation, elongation, and termination. Research over the last decade has blurred these divisions and emphasized the tightly regulated transitions that occur as RNA
Autor:
Hojoong Kwak, John T. Lis
Publikováno v:
Annual Review of Genetics. 47:483-508
Elongation is becoming increasingly recognized as a critical step in eukaryotic transcriptional regulation. Although traditional genetic and biochemical studies have identified major players of transcriptional elongation, our understanding of the imp
Publikováno v:
Annual Review of Microbiology. 67:113-139
Multisubunit RNA polymerases are complex protein machines that require a specificity factor for the recognition of a specific transcription start site. Although bacterial σ factors are thought to be quite different from the specificity factors emplo
Publikováno v:
Annual Review of Microbiology. 62:211-233
The elongation phase of transcription by RNA polymerase is highly regulated and modulated. Both general and operon-specific elongation factors determine the local rate and extent of transcription to coordinate the appearance of transcript with its us
Autor:
Sonja Baumli, Karim-Jean Armache, Patrick Cramer, Alessandro Vannini, Claudia Buchen, Kristin Leike, Anja J. Jasiak, Sebastian R. Geiger, Hubert Kettenberger, Florian Brueckner, Elisabeth Lehmann, Claus-D. Kuhn, Gerke E. Damsma, Stefan Jennebach, Tomislav Kamenski, Stefan Benkert, Jasmin F. Sydow, Anass Jawhari, Stefan Dengl
Publikováno v:
Annual Reviews of Biophysics
The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzyme
Autor:
Tobin R. Sosnick, Tao Pan
Publikováno v:
Annual Review of Biophysics and Biomolecular Structure. 35:161-175
The evolution of RNA sequence needs to satisfy three requirements: folding, structure, and function. Studies on folding during transcription are related directly to folding in the cell. Understanding RNA folding during transcription requires the eluc