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of 183
pro vyhledávání: ''
Autor:
Mario Boehm, Norbert Weissmann, Danny Jonigk, Friedrich Grimminger, Astrid Weiss, Beate Christiane Schlueter, Clemens Ruppert, Ralph T. Schermuly, Baktybek Kojonazarov, Werner Seeger, Dinesh Yerabolu, Andreas Günther, Hossein Ardeschir Ghofrani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the pulmonary vasculopathy including the obliteration of the lung vasculature that causes an increase in vascular resistance and mean blood pressure in the pulmo
Autor:
Di Chen, Yunchao Su, Juanjuan Li, Daile Jia, Philippe P. Roux, Deping Kong, Yujun Shen, Yuanyang Wang, Wang Jian, Yanli Li, Yi Deng, Katrin I. Andreasson, Peiyuan Bai, Richard M. Breyer, Bing Xiao, Guilin Chen, Lingjuan Piao, Bin Li, Ankang Lyu, Caojian Zuo, Guizhu Liu, Yuhu He, Shuai Yan, Jian Zhang, Ying Yu
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Vascular remodeling, including smooth muscle cell hypertrophy and proliferation, is the key pathological feature of pulmonary arterial hypertension (PAH). Prostaglandin I2 analogs (beraprost, iloprost, and treprostinil) are effective in th
Autor:
Angeles Fernandez-Gonzalez, Nicolas Christodoulou, Laura E. Fredenburgh, Helen Christou, Paul B. Dieffenbach, Hannes Hudalla, Gareth R. Willis, Evgenia J. Filatava, Zoe Michael, Robert S. Stearman, Mark W. Geraci, Stella Kourembanas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition induces mild metabolic acidosis and exerts protective effects in hypoxic
Autor:
Anick Langlois, Kim Santerre, David Marsolais, Ynuk Bossé, Audrey Lee-Gosselin, Laetitia J A Lai, Jean-François Lauzon-Joset, Elyse Y. Bissonnette
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:276-284
In allergic asthma, homeostatic pathways are dysregulated, which leads to an immune response toward normally innocuous antigens. The CD200-CD200 receptor pathway is a central regulator of inflammation, and CD200 expression was recently found to be do
Autor:
Clary B. Clish, Stéphane J. H. Ricoult, Brendan D. Manning, Elizabeth P. Henske, Damir Khabibullin, Carmen Priolo, Harilaos Filippakis, Jane J. Yu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:33-41
Lymphangioleiomyomatosis (LAM) is a destructive lung disease affecting women. LAM is caused by mutations in the tuberous sclerosis complex (TSC) genes. The TSC protein complex inhibits the mechanistic/mammalian target of rapamycin complex 1 (mTORC1),
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 191:704-710
Apnea of prematurity, which is prevalent among infants born at less than 34 weeks gestation, is treated with caffeine, theophylline, or aminophylline. However, not all newborns respond adequately to, or tolerate, methylxanthine administration, and th
Autor:
David J. Rowlands, Lynn Loughlin, Martin Hussey, Sonia Roberts, Audrey F. Wright, Matthew Thomas, Kirsty M. Mair, Nicholas Duggan, Margaret Nilsen, Josephine Fullerton, Margaret R. MacLean
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 190:456-467
Rationale: The incidence of pulmonary arterial hypertension is greater in women, suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males, exogenously administered estrogen can protect against pulmonary hypertension
Autor:
Carl W. White, Tara B. Hendry-Hofer, Jacqueline S. Rioux, Rhonda B. Garlick, Livia A. Veress, Joan E. Loader
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 48:439-447
Sulfur mustard (SM) inhalation causes the rare but life-threatening disorder of plastic bronchitis, characterized by bronchial cast formation, resulting in severe airway obstruction that can lead to respiratory failure and death. Mortality in those r
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 48:299-305
Epithelial injury and airway hyperresponsiveness are prominent features of asthma. We have previously demonstrated that laser ablation of single epithelial cells immediately induces global airway constriction through Ca(2+)-dependent smooth muscle sh
Autor:
Zaid Abassi, Gidon Berger, Reem Ismael-Badarneh, Ronit Tal, Bishara Bishara, Edmond Sabo, Geula Klorin, Zaher S. Azzam, Julia Guetta
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 47:583-588
In the last two decades, the role of the alveolar active sodium transport was extensively studied and was found to play a crucial role in regulating alveolar fluid clearance (AFC), and thus in keeping the airspaces free of edema. The recent developme