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Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 27:345-352
Responses of isolated type II alveolar cells to fibroblast growth factors (FGF) have been shown to be sensitive to the level of sulfation in extracellular matrix (ECM) substrata. These observations may reflect the specific in situ distribution and le
Autor:
Robert J. Bridges, Fuquan Chen, Yanying Dai, Steven M. Rowe, Xiaojiao Xue, David M. Bedwell, Ming Du, Jeong S. Hong, Valery Belakhov, Jochen Schacht, Timor Baasov, Venkateshwar Mutyam, Liping Tang, Moran Shalev, Silpak Biswas, Laura A. Jackson
New drugs are needed to enhance premature termination codon (PTC) suppression to treat the underlying cause of cystic fibrosis (CF) and other diseases caused by nonsense mutations. We tested new synthetic aminoglycoside derivatives expressly develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd60151a0e171101e0cc9f6d6da01e6
https://europepmc.org/articles/PMC4068923/
https://europepmc.org/articles/PMC4068923/
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 21:30-36
The effects of concomitant P1-receptor stimulation on peak intracellular Ca2+ release by extracellular adenosine 5'-triphosphate (ATP) and 5-hydroxytryptamine (5-HT) were investigated in cultured airway smooth-muscle (ASM) cells. The results show tha
Autor:
Jon A. Hotchkiss, Patty Spencer, Jack R. Harkema, Kate Slack, Hye-Youn Cho, Karen Regan, Roger Hilaski
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 18:91-99
Ozone (O3) is the principal oxidant pollutant in photochemical smog. Repeated exposures to O3 induces inflammation and mucous cell metaplasia in the nasal airways of laboratory animals. Our study was designed to determine the efficacy of a topical an
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 156:600-608
Idiopathic pulmonary fibrosis (IPF) is characterized by an alveolitis with epithelial and endothelial damage progressing to fibrosis. Numerous mediators have been implicated in this complex process. Studies in humans have shown that endothelin-1 (ET-
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 153:1116-1122
It has been suggested that surfactant protein-A (SP-A) protects surfactant activity from inhibitors such as fibrinogen. Substantial evidence indicates that inhibition of surfactant activity is often important in the pathogenesis of acute respiratory
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 152:1796-1804
Tachykinins released from sensory airway nerves have been shown to increase vascular permeability and plasma-protein extravasation (PPE) in rodent airways. We previously demonstrated that in Fisher (F344) rats, tachykinins cause bronchoconstriction m
Autor:
Paul J. Christensen, R A McDonald, J. J. Fak, Robert Paine, Galen B. Toews, L. R. Armstrong, Gwo Hsiao Chen
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 13:426-433
The presentation and recognition of foreign antigen is the critical initial event in the development of local immunity. In the lung, antigen-presenting cell activity is largely attributable to pulmonary dendritic cells (DC) that are distributed along
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 151:1165-1169
The possible role of nitric oxide (NO) in the regulation of airway tone remains to be fully explored. In the present study we examined the effect of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase, on airway responsiveness in r
Anti-edema action of formoterol in rat trachea does not depend on capsaicin-sensitive sensory nerves
Autor:
Donald M. McDonald, I. Sulakvelidze
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 149:232-238
The beta 2-adrenergic agonist formoterol has been shown to inhibit plasma extravasation in the respiratory mucosa associated with neurogenic inflammation as well as that caused by histamine or bradykinin. It is unknown whether these effects of formot