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Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 37:193-201
Idiopathic pulmonary fibrosis (IPF) is a progressive, scarring lung disease characterized by fibroblast accumulation and deposition of collagen. Factors that promote growth and/or survival of fibroblasts are potential therapeutic targets. Methionine
Autor:
Toshikazu Nakamura, Hiroyuki Shiono, Norihisa Shigemura, Meinoshin Okumura, Yoshiki Sawa, Akifumi Matsuyama, Yukiko Imanishi, Shinya Mizuno
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 174:1199-1205
Hepatocyte growth factor (HGF) is a potent regenerative factor generated after a lung injury, and HGF supplementation after surgical reduction has been shown to enhance compensatory growth in remnant lungs and improve pathophysiologic conditions in a
Autor:
Sanna Padela, Judy Cabacungan, A. Keith Tanswell, Samuel Shek, Rosetta Belcastro, Robert P. Jankov, Man Yi
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:907-914
Our core hypothesis is that growth factors that have dysregulated expression during experimental neonatal lung injury are likely to be involved in normal postnatal lung growth and alveologenesis.To determine if hepatocyte growth factor (HGF) is upreg
Autor:
Toshikazu Nakamura, Hiroshige Nakano, Takatsugu Yamada, Michiyoshi Hisanaga, Shinya Mizuno, Yoshiyuki Nakajima, Kunio Matsumoto
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 162:707-715
Hepatocyte growth factor (HGF) has recently been noted to function as a pulmotrophic factor for lung regeneration. The present study was conducted to determine if HGF would be induced in a rat model of pulmonary ischemia-reperfusion (IR) injury, whic
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 161:558-566
Lymphocyte migration from the blood into the lung has been suggested as being responsible for the increase of lymphocytes, in particular CD4 T cells, in the bronchoalveolar lavage (BAL) and bronchial mucosa in human asthma, but so far there has been
Autor:
Philip A. Bromberg, Robert B. Devlin, Chong S. Kim, Hillel S. Koren, Daniel L. Costa, John C. Lay, William D. Bennett, Andrew J. Ghio
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:631-642
Bronchoalveolar lavage (BAL) was used to sample lung cells and biochemical components in the lung air spaces at various times from 1 to 91 d after intrapulmonary instillation of 2.6 microm-diameter iron oxide particles in human subjects. The instilla
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 159:626-633
Exposure to hyperoxia causes lung injury, decreases active sodium transport and lung edema clearance in rats. Dopamine (DA) increases lung edema clearance by stimulating vectorial Na+ flux and Na, K-ATPase function in rat alveolar epithelium. This st
Autor:
Jon A. Hotchkiss, Patty Spencer, Jack R. Harkema, Kate Slack, Hye-Youn Cho, Karen Regan, Roger Hilaski
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 18:91-99
Ozone (O3) is the principal oxidant pollutant in photochemical smog. Repeated exposures to O3 induces inflammation and mucous cell metaplasia in the nasal airways of laboratory animals. Our study was designed to determine the efficacy of a topical an
Autor:
Frank F. Sun, Karen P. Kolbasa, William E. Fleming, Robert L. Griffin, Jia En Chin, Bruce M. Taylor, Stephen F. Fidler, Ivan M. Richards
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 17:757-766
Increased microvascular permeability and mucosal edema are pathological features of airway inflammation in asthma. In this study, we investigated the characteristics of the edema response occurring in a model of antigen-induced lung inflammation in s
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 156:600-608
Idiopathic pulmonary fibrosis (IPF) is characterized by an alveolitis with epithelial and endothelial damage progressing to fibrosis. Numerous mediators have been implicated in this complex process. Studies in humans have shown that endothelin-1 (ET-