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Autor:
Angeles Fernandez-Gonzalez, Nicolas Christodoulou, Laura E. Fredenburgh, Helen Christou, Paul B. Dieffenbach, Hannes Hudalla, Gareth R. Willis, Evgenia J. Filatava, Zoe Michael, Robert S. Stearman, Mark W. Geraci, Stella Kourembanas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition induces mild metabolic acidosis and exerts protective effects in hypoxic
Autor:
Anick Langlois, Kim Santerre, David Marsolais, Ynuk Bossé, Audrey Lee-Gosselin, Laetitia J A Lai, Jean-François Lauzon-Joset, Elyse Y. Bissonnette
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:276-284
In allergic asthma, homeostatic pathways are dysregulated, which leads to an immune response toward normally innocuous antigens. The CD200-CD200 receptor pathway is a central regulator of inflammation, and CD200 expression was recently found to be do
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
The alveolar epithelium serves as a barrier to the entry of potential respiratory pathogens. Alveolar Type II (TII) cells have immunomodulatory functions, but whether Type I (TI) cells, which comprise approximately 95% of the alveolar epithelium, als
Fluorinated Groups Mediate the Immunomodulatory Effects of Volatile Anesthetics in Acute Cell Injury
Autor:
Inge K. Herrmann, Martin Urner, Christa Booy, Wendelin J. Stark, Melanie Hasler, Beatrice Beck-Schimmer, Björn Müller-Edenborn, Livia Reyes, Andreas Schlicker, Ludwig K. Limbach, Birgit Roth-Z'Graggen
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 45:617-624
Volatile anesthetics are known to attenuate inflammatory response and tissue damage markers in acute organ injury. It is unclear whether these beneficial effects of volatile anesthetics are mediated by the ether basic structure or by characteristics
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 173:769-776
The model most often used to study the pathogenesis of pulmonary fibroses is the bleomycin (BLM)-induced lung fibrosis model. Several treatments have been efficacious in this model, but not in the clinic.To describe the time course of inflammation an
Autor:
Robert J. Shaw, Matthew C. Catley, Kerryn McCluskie, Tony J. Savage, Jorge De Alba, Clarissa J. Watts, Robert Newton, Saleem Haj-Yahia, Maria G. Belvisi, K. Tao Pun, Sissie Wong, Mark A. Birrell, Elizabeth Hardaker
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:962-971
Rationale Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion molecules. NF-kappaB is held inactive in the cytoplasm, bound to I-kappaB. The r
Autor:
Philip A. Bromberg, Robert B. Devlin, Chong S. Kim, Hillel S. Koren, Daniel L. Costa, John C. Lay, William D. Bennett, Andrew J. Ghio
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:631-642
Bronchoalveolar lavage (BAL) was used to sample lung cells and biochemical components in the lung air spaces at various times from 1 to 91 d after intrapulmonary instillation of 2.6 microm-diameter iron oxide particles in human subjects. The instilla
Effects of Systemic and Local Immunization on Alveolar Epithelial Permeability to Protein in the Rat
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 157:324-327
This study aimed to characterize the effect on alveolar epithelial permeability to protein as a result of immunization when animals were reexposed to antigen. Antigen (bovine serum albumin [BSA]) and a related bystander protein (human serum albumin [
Autor:
Jon A. Hotchkiss, Patty Spencer, Jack R. Harkema, Kate Slack, Hye-Youn Cho, Karen Regan, Roger Hilaski
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 18:91-99
Ozone (O3) is the principal oxidant pollutant in photochemical smog. Repeated exposures to O3 induces inflammation and mucous cell metaplasia in the nasal airways of laboratory animals. Our study was designed to determine the efficacy of a topical an
Autor:
Frank F. Sun, Karen P. Kolbasa, William E. Fleming, Robert L. Griffin, Jia En Chin, Bruce M. Taylor, Stephen F. Fidler, Ivan M. Richards
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 17:757-766
Increased microvascular permeability and mucosal edema are pathological features of airway inflammation in asthma. In this study, we investigated the characteristics of the edema response occurring in a model of antigen-induced lung inflammation in s