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Autor:
Toshikazu Nakamura, Hiroyuki Shiono, Norihisa Shigemura, Meinoshin Okumura, Yoshiki Sawa, Akifumi Matsuyama, Yukiko Imanishi, Shinya Mizuno
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 174:1199-1205
Hepatocyte growth factor (HGF) is a potent regenerative factor generated after a lung injury, and HGF supplementation after surgical reduction has been shown to enhance compensatory growth in remnant lungs and improve pathophysiologic conditions in a
Autor:
Sanna Padela, Judy Cabacungan, A. Keith Tanswell, Samuel Shek, Rosetta Belcastro, Robert P. Jankov, Man Yi
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:907-914
Our core hypothesis is that growth factors that have dysregulated expression during experimental neonatal lung injury are likely to be involved in normal postnatal lung growth and alveologenesis.To determine if hepatocyte growth factor (HGF) is upreg
Autor:
Toshikazu Nakamura, Hiroshige Nakano, Takatsugu Yamada, Michiyoshi Hisanaga, Shinya Mizuno, Yoshiyuki Nakajima, Kunio Matsumoto
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 162:707-715
Hepatocyte growth factor (HGF) has recently been noted to function as a pulmotrophic factor for lung regeneration. The present study was conducted to determine if HGF would be induced in a rat model of pulmonary ischemia-reperfusion (IR) injury, whic
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 161:558-566
Lymphocyte migration from the blood into the lung has been suggested as being responsible for the increase of lymphocytes, in particular CD4 T cells, in the bronchoalveolar lavage (BAL) and bronchial mucosa in human asthma, but so far there has been
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 159:626-633
Exposure to hyperoxia causes lung injury, decreases active sodium transport and lung edema clearance in rats. Dopamine (DA) increases lung edema clearance by stimulating vectorial Na+ flux and Na, K-ATPase function in rat alveolar epithelium. This st
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 149:1499-1505
The ovalbumin (OA)-sensitized Brown Norway rat (BN) demonstrates early-response (ER) and late-response (LR) allergic bronchoconstriction. To determine whether these responses could be replicated in vitro, we studied lung explants from 8-wk-old male B