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Autor:
Matthias Ochs, Elena Lopez-Rodriguez
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:399-402
Autor:
Keisuke Tsukioka, Masaaki Arakawa, Takashi Hasegawa, Hiroyuki Takeuchi, Akira Saito, Satoshi Watanabe, Hiroshi Ueno, Yosuke Kimura, Masachika Hayashi, Toshiyuki Koya, Toshiaki Kikuchi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:57-66
It is well known that the prevalence of asthma is higher in athletes, including Olympic athletes, than in the general population. In this study, we analyzed the mechanism of exercise-induced bronchoconstriction by using animal models of athlete asthm
Publikováno v:
C105. WITH ALL MY HEART: SEX, ESTROGEN, AND RIGHT VENTRICLE IN PULMONARY VASCULAR DISEASE AND BEYOND.
Autor:
Deanna Siow, Jeffrey D. Ritzenthaler, Jesse Roman, Gavin E. Arteel, Edilson Torres-Gonzales, Lauren G. Poole, Nikole L. Warner, James P. Luyendyk, Veronica L. Massey
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 57:315-323
Chronic alcohol exposure is a clinically important risk factor for the development of acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). However, the mechanisms by which alcohol sensitizes the lung to development of
Autor:
Garry R. Cutting, Joseph M. Collaco, Karen S. Raraigh, Michael R. Knowles, Johanna M. Rommens, Patrick R. Sosnay, Pierre-Yves Boëlle, Lisa J. Strug, Rhonda G. Pace, John McGready, Scott M. Blackman, Harriet Corvol
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 194:1375-1382
Expanding the use of cystic fibrosis transmembrane conductance regulator (CFTR) potentiators and correctors for the treatment of cystic fibrosis (CF) requires precise and accurate biomarkers. Sweat chloride concentration provides an in vivo assessmen
Rationale: Understanding how cystic fibrosis transmembrane conductance regulator (CFTR) modulators influence comorbid conditions like anemia is of great interest to the cystic fibrosis community. Objectives: To test the hypothesis that CFTR modulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28da113cc700f5441bdbab7d1526923
https://europepmc.org/articles/PMC6394125/
https://europepmc.org/articles/PMC6394125/
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:128-135
Tachyphylaxis of the β2-adrenergic receptor limits the efficacy of bronchodilatory β2-agonists in respiratory disease. Cellular studies in airway smooth muscle (ASM) have shown that inflammatory mediators and infectious stimuli reduce β2-adrenergi
Autor:
Clary B. Clish, Stéphane J. H. Ricoult, Brendan D. Manning, Elizabeth P. Henske, Damir Khabibullin, Carmen Priolo, Harilaos Filippakis, Jane J. Yu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:33-41
Lymphangioleiomyomatosis (LAM) is a destructive lung disease affecting women. LAM is caused by mutations in the tuberous sclerosis complex (TSC) genes. The TSC protein complex inhibits the mechanistic/mammalian target of rapamycin complex 1 (mTORC1),
Autor:
Simon Rousseau, Michael O'Sullivan, Madison Goldberger, Nobuaki Hirota, Yoichiro Hamamoto, Soroor Farahnak, Toby K. McGovern, Benoit Allard, Guy Martel, James G. Martin
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 52:513-522
Chlorine gas (Cl2) inhalation causes oxidative stress, airway epithelial damage, airway hyperresponsiveness (AHR), and neutrophilia. We evaluated the effect of neutrophil depletion on Cl2-induced AHR and its effect on the endogenous antioxidant respo
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 51:370-379
Tobacco smokers often display increased airway hyperreactivity (AHR) when faced with bacterial infections. The present study uses a murine organ-culture model to dissect the mechanisms involved in this exaggerated smooth muscle response. Nicotine sim