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pro vyhledávání: '"Susan S. Margulies"'
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 57:193-203
Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypo
Autor:
Nurit Davidovich, Gladys G. Lawrence, Peter Chhour, Brian C. DiPaolo, Susan S. Margulies, Nadir Yehya
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:156-164
Mechanical ventilation with high tidal volumes has been associated with pulmonary alveolar flooding. Understanding the mechanisms underlying cyclic stretch-induced increases in alveolar epithelial permeability may be important in designing preventive
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 25:584-591
Previous studies have demonstrated that high tidal volumes can cause interstitial and alveolar edema, with degradation of pulmonary epithelial barrier integrity. Separate studies have shown that F-actin disruption and decreased intracellular ATP (ATP