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Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:13-22
Endothelial colony-forming cells (ECFCs) are vascular resident and circulating endothelial cell subtypes with potent angiogenic capacity, a hierarchy of single-cell clonogenic potentials, and the ability to participate in
Autor:
Naoaki Watanabe, Yu Fujita, Jun Nakayama, Yutaro Mori, Tsukasa Kadota, Yusuke Hayashi, Iwao Shimomura, Takashi Ohtsuka, Koji Okamoto, Jun Araya, Kazuyoshi Kuwano, Yusuke Yamamoto
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:708-719
Phenotypic alterations in the lung epithelium have been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, but the precise mechanisms orchestrating this persistent inflammatory process remain unknown because of the comple
Autor:
Yandan Zhang, Lingbing Zhang, Lejiao Mao, Jingchuan Fan, Xuejun Jiang, Na Li, Yinzhen Fan, Ziqi Jiang, Xia Qin, Feng Qiu, Yu Jiang, Gang Liu, Jun Zhang, Chengzhi Chen, Zhen Zou
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:680-694
With the rapid development of nanotechnology, the risks of accidental and/or occupational exposure to zinc oxide nanoparticles (ZnONPs) are increasing. Inhalation of ZnONPs induces metal fume fever in humans and acute lung injury (ALI) in animal mode
Autor:
Quinn A. Bonafiglia, Yu-Qing Zhou, Guangpei Hou, Rhidita Saha, Ying-Han R. Hsu, Jonah Burke-Kleinman, Michelle P. Bendeck
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:562-573
Pulmonary hypertension (PH) is a multifaceted condition characterized by elevated pulmonary arterial pressure, which can result in right ventricular dysfunction and failure. Disorders of lung development can present with secondary PH, which is a lead
Autor:
Kyung Sook Hong, Kassandra Pagan, William Whalen, Rebecca Harris, Jianjun Yang, Heather Stout-Delgado, Soo Jung Cho
Publikováno v:
Am J Respir Cell Mol Biol
Influenza infection induces lung epithelial cell injury via programmed cell death. Glutathione, a potent antioxidant, has been reported to be associated with influenza infection. We hypothesized that lung epithelial cell death during influenza infect
Autor:
Julia Frankenberg Garcia, Andrew V. Rogers, Judith C. W. Mak, Andrew J. Halayko, Christopher K.M. Hui, Bingling Xu, Kian Fan Chung, Tristan Rodriguez, Charalambos Michaeloudes, Pankaj K. Bhavsar
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:471-481
Mitochondrial dysfunction has been reported in chronic obstructive pulmonary disease (COPD). Transfer of mitochondria from mesenchymal stem cells to airway smooth muscle cells (ASMCs) can attenuate oxidative stress-induced mitochondrial damage. It is
Autor:
David Scieszka, Stephanie D. Byrum, Samuel G. Mackintosh, Matthew Madison, John Knight, Matthew J. Campen, Farrah Kheradmand
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:503-506
Autor:
Ragini Vittal, Amanda J. Fisher, Eric L. Thompson, Ellyse M. Cipolla, Hongmei Gu, Elizabeth A. Mickler, Ananya Varre, Manisha Agarwal, Kevin K. Kim, Michael R. Vasko, Bethany B. Moore, Vibha N. Lama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:459-470
CD55 or decay accelerating factor (DAF), a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored protein, confers a protective threshold against complement dysregulation which is linked to the pathogenesis of idiopathic pulmonary fibrosi
Autor:
Tayyab Rehman, Philip H. Karp, Andrew L. Thurman, Steven E. Mather, Akansha Jain, Ashley L. Cooney, Patrick L. Sinn, Alejandro A. Pezzulo, Michael E. Duffey, Michael J. Welsh
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:491-502
In cystic fibrosis (CF), reduced HCOsub3/subsup-/supsecretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pHsubASL/sub) in CF may help identify novel targets and faci
Autor:
Belinda J. Hernandez, Margo P. Cain, Anne M. Lynch, Jose R. Flores, Michael J. Tuvim, Burton F. Dickey, Jichao Chen
Publikováno v:
Am J Respir Cell Mol Biol
The lung epithelium forms the first barrier against respiratory pathogens and noxious chemicals; however, little is known about how more than 90% of this barrier, made of AT1 (alveolar type 1) cells, responds to injury. Using the Sendai virus to mode