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Publikováno v:
Am J Respir Cell Mol Biol
Respiratory infections from influenza A virus (IAV) cause substantial morbidity and mortality in children relative to adults. T cells play a critical role in the host response to IAV by supporting the innate and humoral responses, mediating cytotoxic
Publikováno v:
Am J Respir Cell Mol Biol
Bronchopulmonary dysplasia (BPD) is a common and serious complication associated with preterm birth. The pathogenesis of BPD is incompletely understood, and there is an unmet clinical need for effective treatments. The role of autophagy as a potentia
Autor:
J. Dixon Johns, Marina Mazur, A. Lenzie, Steven M. Rowe, Lianwu Fu, Susan E. Birket, Carolyn Durham, Emily Falk Libby, Adegboyega Timothy Adewale, Copeland Dan, Guillermo J. Tearney, Evan R. Boitet, Courtney Fernandez Petty
Publikováno v:
Am J Respir Cell Mol Biol
Defective airway mucus clearance is a defining characteristic of cystic fibrosis lung disease, and improvements to current mucolytic strategies are needed. Novel approaches targeting a range of contributing mechanisms are in various stages of preclin
Autor:
Rhianna E. Lee, Hong Dang, Zachary H Boggs, Teresa M. Mascenik, Robert Tarran, Catherine A. Lewis, Sean M. Miller, Scott H. Randell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Cystic fibrosis (CF) is caused by loss-of-function mutations in the CFTR (CF transmembrane regulator) gene. Pharmacologic therapies directed at CFTR have been developed but are not effective for mutations that result in little or no mRNA or protein e
Autor:
Matthias Ochs, Elena Lopez-Rodriguez
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:399-402
Autor:
E. Kaitlynn Allen, Gabriela Maron, Li Tang, Timothy Brahm, Tim Flerlage, Joshua Wolf, Jeremy Chase Crawford, Aisha Souquette, Paul G. Thomas, Brandon M. Triplett, Yilun Sun
Publikováno v:
Am J Respir Cell Mol Biol
Allogeneic hematopoietic cell-transplant (alloHCT) recipients are at increased risk of complications from viral respiratory-tract infections (vRTIs). We measured cytokine concentrations in nasal washes (NWs) from pediatric alloHCT recipients to bette
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Electronic nicotine delivery system (ENDS) use is outpacing our understanding of its potential harmful effects. Homeostasis of the lung is maintained through proper balance of cell death, efferocytic clearance, and phagocytosis of pathogens. To inves
Autor:
Richard Saffery, Matthew Burton, Shivanthan Shanthikumar, Sarath Ranganathan, Melanie R Neeland
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:152-159
Childhood pulmonary diseases not only cause childhood morbidity and mortality but also can cause long-term pulmonary impairment. The clinical management of many childhood pulmonary diseases is hampered by a limited understanding of the underlying pat
Autor:
Thi K. Tran-Nguyen, Daniel J. Kass, Jianmin Xue, Carol Feghali-Bostwick, Frank C. Sciurba, Steven R. Duncan
Publikováno v:
Am J Respir Cell Mol Biol
Idiopathic pulmonary fibrosis (IPF) is a lethal, medically refractory syndrome characterized by intrapulmonary accumulations of extracellular matrix (ECM) proteins produced by fibroblasts. Activation, clonal expansion, and differentiation of lymphocy
Autor:
Iain R, Konigsberg, Ivana V, Yang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:589-590