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Autor:
Ragini Vittal, Amanda J. Fisher, Eric L. Thompson, Ellyse M. Cipolla, Hongmei Gu, Elizabeth A. Mickler, Ananya Varre, Manisha Agarwal, Kevin K. Kim, Michael R. Vasko, Bethany B. Moore, Vibha N. Lama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:459-470
CD55 or decay accelerating factor (DAF), a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored protein, confers a protective threshold against complement dysregulation which is linked to the pathogenesis of idiopathic pulmonary fibrosi
Autor:
Shixiu Liang, Zicong Zhou, Zili Zhou, Jieyi Liu, Wufeng Huang, Hangming Dong, Fei Zou, Haijin Zhao, Changhui Yu, Shaoxi Cai
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:648-660
Thymic stromal lymphopoietin presents in two distinct isoforms: short-form (sfTSLP) and long-form (lfTSLP). lfTSLP promotes inflammation, whereas sfTSLP inhibits inflammation, in allergic asthma. However, little is known about the regulation of lfTSL
Autor:
Joo Heon Yoon, Seol Ah Yoon, Ji Min Song, Sang-Nam Lee, Augustine M.K. Choi, Hyung Chul Kim, Ji-Suk Ahn, Su Jin Kim
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:247-259
In allergic airway diseases, intermediate progenitor cells (IPCs) increase in number in the surface epithelium. IPCs arise from basal cells, the origin of hallmark pathological changes, including goblet cell hyperplasia and mucus hypersecretion. Thus
Publikováno v:
American journal of respiratory cell and molecular biology, vol 63, iss 1
Am J Respir Cell Mol Biol
Am J Respir Cell Mol Biol
Recent research on extracellular vesicles (EVs) has provided new insights into pathogenesis and potential therapeutic options for acute respiratory distress syndrome (ARDS). EVs are membrane-bound anuclear structures that carry important intercellula
Active mTOR in Lung Epithelium Promotes Epithelial–Mesenchymal Transition and Enhances Lung Fibrosis
Autor:
Hideaki Isago, Akihisa Mitani, Takahide Nagase, Satoshi Noguchi, Taro Ishimori, Yu Mikami, Megumi Tarui, Naoya Miyashita, Minako Saito
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/or myofibroblasts, but not in the epithelial cells. In this study, we
Publikováno v:
Am J Respir Cell Mol Biol
Type II alveolar epithelial cells (AEC2s) play an essential role in the function and maintenance of the pulmonary epithelium. Several transgenic mice have been developed to study the function of these cells in vivo by using the human SFTPC promoter t
Autor:
Angeles Fernandez-Gonzalez, Nicolas Christodoulou, Laura E. Fredenburgh, Helen Christou, Paul B. Dieffenbach, Hannes Hudalla, Gareth R. Willis, Evgenia J. Filatava, Zoe Michael, Robert S. Stearman, Mark W. Geraci, Stella Kourembanas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition induces mild metabolic acidosis and exerts protective effects in hypoxic
Autor:
Teja Gregorc, Craig K. Docherty, Afshan Dean, Margaret R. MacLean, Katie Y. Harvey, Margaret Nilsen, Nicholas W. Morrell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:320-330
Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH). The mechanism by which Su exaccer
Autor:
Jeremy A. Hirota, Jenny P. Nguyen
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport mechanisms in the airways are not well understood. cAMP stimulates anion efflux through the cystic fibrosis (CF) transmembrane conductance regulator (CFTR; ABCC7) a
Autor:
Akihiko Hoji, Shreya M. Kanth, James D. Londino, Rama K. Mallampalli, Nathaniel M. Weathington, Sally E. Wenzel, Qiaoke Gong, John B. Trudeau, Mauricio Rojas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 57:346-354
IL-25 and IL-4 signaling in the setting of infection or allergic responses can drive Type 2 inflammation. IL-25 requires the IL-17 receptor B (IL-17Rb) to mediate signaling through nuclear factor κ B (NF-κB) transcriptional activation. Despite the