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Autor:
Joo Heon Yoon, Seol Ah Yoon, Ji Min Song, Sang-Nam Lee, Augustine M.K. Choi, Hyung Chul Kim, Ji-Suk Ahn, Su Jin Kim
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:247-259
In allergic airway diseases, intermediate progenitor cells (IPCs) increase in number in the surface epithelium. IPCs arise from basal cells, the origin of hallmark pathological changes, including goblet cell hyperplasia and mucus hypersecretion. Thus
Active mTOR in Lung Epithelium Promotes Epithelial–Mesenchymal Transition and Enhances Lung Fibrosis
Autor:
Hideaki Isago, Akihisa Mitani, Takahide Nagase, Satoshi Noguchi, Taro Ishimori, Yu Mikami, Megumi Tarui, Naoya Miyashita, Minako Saito
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/or myofibroblasts, but not in the epithelial cells. In this study, we
Autor:
Angeles Fernandez-Gonzalez, Nicolas Christodoulou, Laura E. Fredenburgh, Helen Christou, Paul B. Dieffenbach, Hannes Hudalla, Gareth R. Willis, Evgenia J. Filatava, Zoe Michael, Robert S. Stearman, Mark W. Geraci, Stella Kourembanas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition induces mild metabolic acidosis and exerts protective effects in hypoxic
Autor:
Teja Gregorc, Craig K. Docherty, Afshan Dean, Margaret R. MacLean, Katie Y. Harvey, Margaret Nilsen, Nicholas W. Morrell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:320-330
Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH). The mechanism by which Su exaccer
Autor:
Jeremy A. Hirota, Jenny P. Nguyen
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport mechanisms in the airways are not well understood. cAMP stimulates anion efflux through the cystic fibrosis (CF) transmembrane conductance regulator (CFTR; ABCC7) a
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 56:322-331
Pneumocystis pneumonia (PCP) is an opportunistic, infectious disease that is prevalent in immunosuppressed hosts. Corticosteroid treatment is the most significant risk factor for patients with PCP who are human immunodeficiency virus negative, althou
Autor:
Steven G. Kelsen, Beata Kosmider, Curt R. Freed, Karim Bahmed, Hong Wei Chu, Rubin M. Tuder, Russell P. Bowler, Wenbo Zhou, Robert J. Mason, Elise M. Messier
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 55:439-449
Cigarette smoke (CS) is a main source of oxidative stress and a key risk factor for emphysema, which consists of alveolar wall destruction. Alveolar type (AT) II cells are in the gas exchange regions of the lung. We isolated primary ATII cells from d
Autor:
Delphine Ohayon, Guiti Thévenot, Clémence Martin, Manal Alkan, Magali Pederzoli-Ribeil, Nathalie Thieblemont, Arnaud Millet, Julie Mocek, Véronique Witko-Sarsat, Marco A. Cassatella, Nicola Tamassia, Pierre-Régis Burgel, Céline Candalh
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:740-750
Neutrophil-associated inflammation during Pseudomonas aeruginosa lung infection is a determinant of morbidity in cystic fibrosis (CF). Neutrophil apoptosis is a key factor in inflammation resolution and is controlled by cytosolic proliferating cell n
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Human rhinovirus (RV) is the major cause of common cold, and it also plays a significant role in asthma and asthma exacerbation. The airway epithelium is the primary site of RV infection and production. In contrast, monocytic cells (e.g., monocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc4e69cc0ef154b7996746fb66de327
https://europepmc.org/articles/PMC5576581/
https://europepmc.org/articles/PMC5576581/
Autor:
Alar Aab, Jacek Musiał, Anna Gielicz, Lucyna Mastalerz, Mübeccel Akdis, Hanna Plutecka, Marek Sanak, Magdalena Hubalewska-Mazgaj, Grazyna Bochenek, Bogdan Jakiela, Rafał Januszek, Jerzy Soja, Cezmi A. Akdis
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 51:229-241
Human rhinoviruses (RVs) are a major cause of exacerbations in asthma and other chronic airway diseases. A characteristic feature of asthmatic epithelium is goblet cell metaplasia and mucus hypersecretion. Bronchial epithelium is also an important so