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pro vyhledávání: ''
Autor:
Ru-Jeng Teng, Girija G. Konduri, Ujala Rana, Adeleye J. Afolayan, Abdul K. Parchur, Megha Sharma, Chintamani Joshi, Amit Joshi, Teresa Michalkiewicz
Publikováno v:
Am J Respir Cell Mol Biol
Impaired angiogenesis function in pulmonary artery endothelial cells (PAEC) contributes to persistent pulmonary hypertension of the newborn (PPHN). Decreased nitric oxide (NO) amounts in PPHN lead to impaired mitochondrial biogenesis and angiogenesis
Autor:
Matthias Ochs, Elena Lopez-Rodriguez
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:399-402
Autor:
Souheil El-Chemaly, Ehab A. Ayaub, Konstantin Tsoyi, Kevin Xiong, Yuanyuan Shi, Raju V. V. Tatituri, Sarah G. Chu, Bonna Ith, Fong-Fu Hsu, Xiaoliang Liang, Derek E. Byers, Ivan O. Rosas, Julian A. Villalba, Edy Y. Kim
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids, such as palmitic acid (PA), activate endoplasmic reticulum (ER) stress, a cellular stress response associated with the development of idiopathic pulmona
Autor:
Benjamin Grimmer, Wolfgang M. Kuebler
Publikováno v:
Am J Respir Cell Mol Biol
Chronic hypoxia (CH) augments depolarization-induced pulmonary vasoconstriction through superoxide-dependent, Rho kinase–mediated Ca(2+) sensitization. Nicotinamide adenine dinucleotide phosphate oxidase and EGFR (epidermal growth factor receptor)
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 muta
Autor:
Daniel Henrion, Roger Marthan, Marilyne Campagnac, Thomas Ducret, Juliette Deweirdt, Jean-François Quignard, Isabelle Baudrimont, Jean-Pierre Savineau, Guillaume Gilbert, Audrey Lhomme, Thomas Pele, Christelle Guibert
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
In intrapulmonary arteries (IPA), endothelial cells (EC) respond to mechanical stimuli by releasing vasoactive factors to set the vascular tone. Piezo1, a stretch-activated, calcium-permeable channel, is a sensor of mechanical stress in EC. The prese
Autor:
Nicholas W. Morrell, Mark Southwood, Paul D. Upton, Amer A. Rana, Benjamin J. Dunmore, Stephen Moore, Christopher L.-H. Huang, Xudong Yang, Alexi Crosby, Eric D. Austin, Lu Long
Mutations in the gene encoding BMPR2 (bone morphogenetic protein type 2 receptor) are the major cause of heritable pulmonary arterial hypertension (PAH). Point mutations in the BMPR2 ligand-binding domain involving cysteine residues (such as C118W) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83be5bc57cfa8a0e7aea0cb8b5370d05
https://www.repository.cam.ac.uk/handle/1810/304151
https://www.repository.cam.ac.uk/handle/1810/304151
Autor:
Elena Lopez-Rodriguez, Nuria Roldan, Begoña Garcia-Alvarez, Timothy E. Weaver, Matthias Ochs, Kirsten Sehlmeyer, Lars Knudsen, Jannik Ruwisch, Jesús Pérez-Gil
Publikováno v:
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
instname
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
instname
Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling in aging mice and alveolar lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234800b50c0be2cb157c8f02ab37a5d7
https://eprints.ucm.es/id/eprint/62220/1/Roldan-DBBM-Air-Space-Distension.pdf
https://eprints.ucm.es/id/eprint/62220/1/Roldan-DBBM-Air-Space-Distension.pdf
Autor:
Andrea L. Frump, Mona Selej, Bakhtiyor Yakubov, Marjorie Albrecht, Irina Petrache, Jordan A. Wood, Tim Lahm
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 59:114-126
17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain
Autor:
Sam Paek, Elena Chung, Ana Lucia Fuentes, Natalia M. Bexiga, Reynold A. Panettieri, Maia L. Corpuz, Kwangmi Ahn, Shreya Narayan, Vishal Parikh, Christie A. Ojiaku, Victoria Lui, Francisco J. Nuñez, Steven S. An, Rennolds S. Ostrom, Anthony Schwab, Jazmean K. Williams
Publikováno v:
Am J Respir Cell Mol Biol
Helper T effector cytokines implicated in asthma modulate the contractility of human airway smooth muscle (HASM) cells. We have reported recently that a profibrotic cytokine, transforming growth factor (TGF)-β1, induces HASM cell shortening and airw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7ea344da8a843f64829389258d6e1a
https://europepmc.org/articles/PMC6670035/
https://europepmc.org/articles/PMC6670035/