Zobrazeno 51 - 60
of 3 542
pro vyhledávání: ''
Autor:
Kelly E. Dooley, Sachiko Miyahara, Florian von Groote-Bidlingmaier, Xin Sun, Richard Hafner, Susan L. Rosenkranz, Elisa H. Ignatius, Eric L. Nuermberger, Laura Moran, Kathleen Donahue, Susan Swindells, Naadira Vanker, Andreas H. Diacon, Rachel Issa, Christopher Lane, Mark Lojacono, Rachel Mahachi, William Murtaugh, Lynette Purdue, Akbar Shahkolahi, Ronald Ssenyonga
Publikováno v:
Am J Respir Crit Care Med
Rationale: High-dose isoniazid is recommended in short-course regimens for multidrug-resistant tuberculosis (TB). The optimal dose of isoniazid and its individual contribution to efficacy against T...
Autor:
Abdul K. Parchur, Brianna Entringer, Teresa Michalkiewicz, Girija G. Konduri, Ru-Jeng Teng, Amit Joshi, Ujala Rana, Emily Callan
Publikováno v:
Am J Respir Cell Mol Biol
Decreased angiogenesis contributes to persistent pulmonary hypertension of the newborn (PPHN); mechanisms remain unclear. AMPK (5′AMP activated protein kinase) is a key regulator of cell metabolism. We investigated the hypothesis that a decrease in
Autor:
Di Chen, Yunchao Su, Juanjuan Li, Daile Jia, Philippe P. Roux, Deping Kong, Yujun Shen, Yuanyang Wang, Wang Jian, Yanli Li, Yi Deng, Katrin I. Andreasson, Peiyuan Bai, Richard M. Breyer, Bing Xiao, Guilin Chen, Lingjuan Piao, Bin Li, Ankang Lyu, Caojian Zuo, Guizhu Liu, Yuhu He, Shuai Yan, Jian Zhang, Ying Yu
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Vascular remodeling, including smooth muscle cell hypertrophy and proliferation, is the key pathological feature of pulmonary arterial hypertension (PAH). Prostaglandin I2 analogs (beraprost, iloprost, and treprostinil) are effective in th
Autor:
Marcelo Malakooti, Matthew F. Barhight, L. Nelson Sanchez-Pinto, Eric L. Wald, Craig M. Smith, Colleen M. Badke, Thomas Moran
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:863-867
Autor:
Christopher H. Goss, Clement L. Ren, Sonya L. Heltshe, Jonathan D Cogen, Dave P. Nichols, M. Skalland, Ranjani Somayaji, Katherine Odem-Davis
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:430-437
Rationale: Chronic azithromycin is commonly used in cystic fibrosis based on short controlled clinical trials showing reductions in pulmonary exacerbations and improved FEV1. Long-term effects are unknown.Objectives: Examine pulmonary outcomes among
Autor:
Sebastian F. Salathe, Nathalie Baumlin, Philip L. Whitney, Juan R. Sabater, Matthias Salathe, Michael D. Kim, Adam Wanner, Frank T. Horrigan, Juliette Sailland, William M. Abraham, John Dennis, Deepika Polineni, Joseph K. David, Charles A. Peloquin, Makoto Yoshida
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:313-324
Rationale: Despite therapeutic progress in treating cystic fibrosis (CF) airway disease, airway inflammation with associated mucociliary dysfunction remains largely unaddressed. Inflammation reduces the activity of apically expressed large-conductanc
Autor:
Sandrine Touzet, Angélique Denis, S. Poupon-Bourdy, Isabelle Durieu, Jean Iwaz, Lydie Lemonnier, Quitterie Reynaud, Muriel Rabilloud, Lamoussa Diabaté
Publikováno v:
Annals of the American Thoracic Society
Annals of the American Thoracic Society, American Thoracic Society, 2019, ⟨10.1513/AnnalsATS.201812-882OC⟩
Annals of the American Thoracic Society, 2019, ⟨10.1513/AnnalsATS.201812-882OC⟩
Annals of the American Thoracic Society, American Thoracic Society, 2019, ⟨10.1513/AnnalsATS.201812-882OC⟩
Annals of the American Thoracic Society, 2019, ⟨10.1513/AnnalsATS.201812-882OC⟩
Rationale: In cystic fibrosis, information on the efficacy of azithromycin past 12 months of treatment is still scarce.Objectives: The study sought to quantify the changes in lung function and the ...
Autor:
Pearce G. Wilcox, Frank Y Chou, Valentine Sergeev, Bradley S. Quon, Grace Y. Lam, Christopher Michael Hamilton
Publikováno v:
Annals of the American Thoracic Society
The effects of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulators on lung function, pulmonary exacerbations, and quality of life have been well documented. However, CF is a multiorgan disease, and therefore an evidence base is
Autor:
Sruti Shiva, Edgar Gutierrez, Melanie J. Scott, Prithu Sundd, Egemen Tutuncuoglu, Tomasz Brzoska, Maritza A. Jimenez, Gregory J. Kato, Simon C. Watkins, Ravi Vats, Tirthadipa Pradhan-Sundd, Mark T. Gladwin, Matthew D. Neal, Adrian E. Morelli, Jude Jonassaint, Margaret F. Bennewitz
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:33-46
Rationale: Intraerythrocytic polymerization of Hb S promotes hemolysis and vasoocclusive events in the microvasculature of patients with sickle cell disease (SCD). Although platelet–neutrophil aggr...
Assessment of Inflammation in Pulmonary Artery Hypertension by 68Ga-Mannosylated Human Serum Albumin
Autor:
Ji Yong Park, Hyun-Ah Kim, Jin Chul Paeng, Jun Bean Park, Minseok Suh, Kibyung Kim, Hyejeong Kang, Hyung Kwan Kim, Yun Sang Lee, Yong Il Kim, Jae Min Jeong, Ye Seul Cho, Jin Kyun Park, Jae-Hoon Choi, Seung Pyo Lee, Jin Wu Nam, Yong Jin Kim
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:95-106
Rationale: Diagnosis and monitoring of patients with pulmonary artery hypertension (PAH) is currently difficult.Objectives: We aimed to develop a noninvasive imaging modality for PAH that tracks th...