Zobrazeno 1 - 10
of 389
pro vyhledávání: ''
Autor:
Xiaoyun Wang, G.L. Kinney, Maor Sauler, Duo Zhang, Michael Tomchaney, Tianshi David Wu, Bartolome R. Celli, Jaroslaw W. Zmijewski, Rick G. Schnellmann, Elizabeth Córdoba-Lanús, Kristan H. Cleveland, Jonathan Mayo, Craig P. Hersh, Judy Tram, John P. Konhilas, Paul R. Langlais, Ciro Casanova, Nadia N. Hansel, Yohannes Tesfaigzi, Samuel Packard, Joselyn Rojas-Quintero, Kevin Doubleday, Ashraf Fawzy, Meredith C. McCormack, Francesca Polverino, Irfan Rahman, Caroline A. Owen, Julie G. Ledford
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Am J Respir Crit Care Med
Am J Respir Crit Care Med
Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation, leading to accelerated lung aging, apoptosis, and emphysema, as well as systemic pathologies. Metformin is beneficial for protecting against aging-related diseases
Autor:
Di Chen, Yunchao Su, Juanjuan Li, Daile Jia, Philippe P. Roux, Deping Kong, Yujun Shen, Yuanyang Wang, Wang Jian, Yanli Li, Yi Deng, Katrin I. Andreasson, Peiyuan Bai, Richard M. Breyer, Bing Xiao, Guilin Chen, Lingjuan Piao, Bin Li, Ankang Lyu, Caojian Zuo, Guizhu Liu, Yuhu He, Shuai Yan, Jian Zhang, Ying Yu
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Vascular remodeling, including smooth muscle cell hypertrophy and proliferation, is the key pathological feature of pulmonary arterial hypertension (PAH). Prostaglandin I2 analogs (beraprost, iloprost, and treprostinil) are effective in th
Autor:
Sebastian F. Salathe, Nathalie Baumlin, Philip L. Whitney, Juan R. Sabater, Matthias Salathe, Michael D. Kim, Adam Wanner, Frank T. Horrigan, Juliette Sailland, William M. Abraham, John Dennis, Deepika Polineni, Joseph K. David, Charles A. Peloquin, Makoto Yoshida
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:313-324
Rationale: Despite therapeutic progress in treating cystic fibrosis (CF) airway disease, airway inflammation with associated mucociliary dysfunction remains largely unaddressed. Inflammation reduces the activity of apically expressed large-conductanc
Autor:
William M. Abraham, Sebastian F. Salathe, Phillip L Whitney, Juan R. Sabater, Samuel Chung, Nathalie Baumlin, Robert B. Moore, John S. Dennis, Michael D Kim, Matthias Salathe
Publikováno v:
Am J Respir Crit Care Med
Rationale: Electronic cigarette (e-cig) use has been widely adopted under the perception of safety. However, possibly adverse effects of e-cig vapor in never-smokers are not well understood. Objectives: To test the effects of nicotine-containing e-ci
Autor:
Angeles Fernandez-Gonzalez, Nicolas Christodoulou, Laura E. Fredenburgh, Helen Christou, Paul B. Dieffenbach, Hannes Hudalla, Gareth R. Willis, Evgenia J. Filatava, Zoe Michael, Robert S. Stearman, Mark W. Geraci, Stella Kourembanas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition induces mild metabolic acidosis and exerts protective effects in hypoxic
Publikováno v:
TP64. TP064 TOBACCO PRODUCT EXPOSURES AND RESPIRATORY HEALTH.
Publikováno v:
TP3. TP003 COVID-19 INFECTIONS, MECHANISMS, AND CLINICAL IMPLICATIONS.
RATIONALE: Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV2). SARS-CoV-2 uses the receptor angiotensin-converting enzyme 2 (ACE2) to gain entry to host cells in the respirator
Autor:
M.P. White, Jason S. Debley, L.M. Rich, Kaitlyn A Barrow, W. E. Harrington, E. R. Vanderwall, S.R. Reeves
Publikováno v:
TP3. TP003 COVID-19 INFECTIONS, MECHANISMS, AND CLINICAL IMPLICATIONS.
RATIONALE: SARS-CoV-2 gains entrance to airway epithelial cells (AECs) through binding of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. However, ACE-2 also converts angiotensin II into angiotensin-(1-7) an
Autor:
Anjaparavanda P. Naren, Jesun Lee, Sunitha Yarlagadda, Yunjie Huang, Karen McCoy, Grace R. Paul
Publikováno v:
Am J Respir Crit Care Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d61a637ef674c6f37f6576b863b85d
https://europepmc.org/articles/PMC8759307/
https://europepmc.org/articles/PMC8759307/
Autor:
Kesimer, Mehmet
Publikováno v:
American Journal of Respiratory and Critical Care Medicine