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Autor:
W.S. Fred Wong, Sheryl S.L. Tan, Trudi Harris, John Kit Chung Tam, Thai Tran, Chang Cheng, Alastair G. Stewart, Wanxing Eugene Ho, Benjamin Ong
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 50:451-458
Airway smooth muscle (ASM) cell hyperplasia contributes to airway wall remodeling (AWR) in asthma. Glucocorticoids, which are used as first-line therapy for the treatment of inflammation in asthma, have limited impact on AWR, and protracted usage of
Autor:
Matthew G. Drake, Gregory D. Scott, Elad Kaufman, Becky J. Proskocil, David B. Jacoby, Allison D. Fryer
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 188:664-672
Toll-like receptors (TLRs) 7 and 8 detect respiratory virus single-stranded RNA and trigger an innate immune response. We recently described rapid TLR7-mediated bronchodilation in guinea pigs.To characterize TLR7 expression and TLR7-induced airway re
Autor:
Olga Ousova, Patrick Berger, Alain-Pierre Gadeau, Heike Wulff, Peter Bradding, Hugues Begueret, Gabrielle Carvalho, Pierre Olivier Girodet, Annaig Ozier, Roger Marthan, Olga Ilina
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2013, 48 (2), pp.212-219. ⟨10.1165/rcmb.2012-0103OC⟩
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2013, 48 (2), pp.212-219. ⟨10.1165/rcmb.2012-0103OC⟩
Key features of asthma include bronchial hyperresponsiveness (BHR), eosinophilic airway inflammation, and bronchial remodeling, characterized by subepithelial collagen deposition, airway fibrosis, and increased bronchial smooth muscle (BSM) mass. The
Autor:
Balaram Ghosh, Lokesh Makhija, Ulaganathan Mabalirajan, Amit Sharma, Tanveer Ahmad, Jyotirmoi Aich, Anurag Agrawal
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 44:531-539
Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma. Statins improve vascular endo
Autor:
Brian J. O'Connor, Ashley Woodcock, Sheila Schwartz, Duncan Richards, Dave Singh, Richard G. Knowles, S. J. Langley
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 176:988-993
Exhaled breath nitric oxide (Fe(NO)) is increased in asthma. NO is produced predominantly by inducible nitric oxide synthase (iNOS).We evaluated the selective and potent iNOS inhibitor GW274150 in asthma.Twenty-eight steroid-naive patients with asthm
Autor:
Robert J. Shaw, Matthew C. Catley, Kerryn McCluskie, Tony J. Savage, Jorge De Alba, Clarissa J. Watts, Robert Newton, Saleem Haj-Yahia, Maria G. Belvisi, K. Tao Pun, Sissie Wong, Mark A. Birrell, Elizabeth Hardaker
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:962-971
Rationale Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion molecules. NF-kappaB is held inactive in the cytoplasm, bound to I-kappaB. The r
Autor:
Jonathan Levin, Giorgio Roscigno, Jennifer Norman, F. A. Sirgel, Nesri Padayatchi, Denis A. Mitchison, Peter R. Donald, Helen McIlleron, P. Bernard Fourie, Roxana Rustomjee
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:128-135
Comparison of the early bactericidal activity (EBA) of rifapentine and its pharmacokinetics with those of rifampin to determine the cause of poor clinical response and regrowth between doses, leading to rifamycin monoresistance at relapse.Determinati
Publikováno v:
American journal of respiratory and critical care medicine, 171(10), 1125-1128. American Thoracic Society
Rationale: Acute lung injury and pneumonia are associated with pulmonary activation of coagulation and suppression of fibrinolysis, resulting in fibrin deposition in the lung. Activated protein C (APC) has systemic anticoagulant effects in patients w
Autor:
Michael B. Fessler, Jonathan G. Lieber, Samithamby Jeyaseelan, G. Scott Worthen, Jerry A. Nick, Scott K. Young, Patrick G. Arndt
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 171:606-615
A growing literature indicates that hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) modulate proinflammatory cellular signaling and functions. No studies to date, however, have addressed whether statins modulate pulmonary inflammatio
In Vivo and In Vitro Effects of SAR 943, a Rapamycin Analogue, on Airway Inflammation and Remodeling
Autor:
Alexandre Trifilieff, Yasushi Fujitani
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 167:193-198
No current therapy is considered to be satisfactory for severe asthma, and alternative approaches are still required for what is a major unmet medical need. In this study, we compared the effect of a rapamycin derivative, SAR 943, with budesonide, us