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Autor:
Claudia A. Staab-Weijnitz
Publikováno v:
Am. J. Respir. Cell Mol. Biol. 66, 363-381 (2022)
Organ fibrosis is characterized by epithelial injury and aberrant tissue repair, where activated effector cells, mostly fibroblasts and myofibroblasts, excessively deposit collagen into the extracellular matrix. Fibrosis frequently results in organ f
Autor:
Angeles Fernandez-Gonzalez, S. Alex Mitsialis, Lawrence S. Prince, Xianlan Liu, Vincent Yeung, Stella Kourembanas, Gareth R. Willis, Elizabeth S. Taglauer, Monica Reis
Publikováno v:
Am J Respir Cell Mol Biol
In preeclamptic pregnancies, a variety of intrauterine alterations lead to abnormal placentation, release of inflammatory and/or antiangiogenic factors, and subsequent fetal growth restriction with significant potential to cause a primary insult to t
Autor:
Xianlan Liu, Angeles Fernandez-Gonzalez, Ali Hashemi Gheinani, Elizabeth S. Taglauer, Gareth R. Willis, S. Alex Mitsialis, Eric Haas, Stella Kourembanas, Maria Ericsson, Monica Reis, Vincent Yeung
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 204:1418-1432
Rationale: Mesenchymal stem/stromal cell (MSC)-small extracellular vesicle (MEx) treatment has shown promise in models of neonatal lung injury. The molecular mechanisms by which MEx afford benefici...
Autor:
Diego F. Alvarez, Talha Nawaz, Ji Young Lee, A. deWeever, Christopher Clarke, Phoibe Renema, Jean-Francois Pittet, Mikhail Alexeyev, Waqar Siddiqui, Ronald Balczon, M.S. Gwin, Chun Zhou, Anna Koloteva, Jonathon P. Audia, Yasaman Eslaamizaad, S.B. Voth, Reece P. Stevens, Mary Kash, Troy Stevens, Viktoriya Pastukh, Brian Fouty, Natalya Kozhukhar, Brant M. Wagener
Publikováno v:
Am J Respir Cell Mol Biol
Low tidal volume ventilation protects the lung in mechanically ventilated patients. The impact of the accompanying permissive hypoxemia and hypercapnia on endothelial cell recovery from injury is poorly understood. CA (carbonic anhydrase) IX is expre
Autor:
Ru-Jeng Teng, Girija G. Konduri, Ujala Rana, Adeleye J. Afolayan, Abdul K. Parchur, Megha Sharma, Chintamani Joshi, Amit Joshi, Teresa Michalkiewicz
Publikováno v:
Am J Respir Cell Mol Biol
Impaired angiogenesis function in pulmonary artery endothelial cells (PAEC) contributes to persistent pulmonary hypertension of the newborn (PPHN). Decreased nitric oxide (NO) amounts in PPHN lead to impaired mitochondrial biogenesis and angiogenesis
Publikováno v:
Am J Respir Cell Mol Biol
Compromised alveolar development and pulmonary vascular remodeling are hallmarks of pediatric lung diseases such as bronchopulmonary dysplasia (BPD) and alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). Although advances in
Autor:
Stuti Agarwal, Aradhana Mohan, Balaji Krishnamachary, Priscilla Y. Hsue, Ling Chen, Ashok Kumar, Navneet K. Dhillon, Alison Morris, Prabhakar Chalise, Aatish Mahajan
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Am J Respir Cell Mol Biol
Am J Respir Cell Mol Biol
Extracellular vesicles (EVs) have emerged as important mediators in cell–cell communication; however, their relevance in pulmonary hypertension (PH) secondary to human immunodeficiency virus (HIV) infection is yet to be explored. Considering that c
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses whi
Publikováno v:
Am J Respir Cell Mol Biol
The extracellular matrix (ECM), a highly organized network of structural and nonstructural proteins, plays a pivotal role in cellular and tissue homeostasis. Changes in the ECM are critical for normal tissue repair, whereas dysregulation contributes
Autor:
Cécile Macquin, Philippe Georgel, Hamid Merdji, Mohamad Kassem, Seiamak Bahram, Kei Kurihara, Aurore De Cauwer, Alicia Sibony, Julie Helms, Chérine Abou Fayçal, Raphaël Clere-Jehl, Laetitia Minniti, Ferhat Meziani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Septic shock and disseminated intravascular coagulation (DIC) are known to be characterized by an endothelial cell dysfunction. The molecular mechanisms underlying this relationship are, however, poorly understood. In this work, we aimed to investiga