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Autor:
Richard Saffery, Matthew Burton, Shivanthan Shanthikumar, Sarath Ranganathan, Melanie R Neeland
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:152-159
Childhood pulmonary diseases not only cause childhood morbidity and mortality but also can cause long-term pulmonary impairment. The clinical management of many childhood pulmonary diseases is hampered by a limited understanding of the underlying pat
Autor:
Michelle L. Manni, John F. Alcorn
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
Calprotectin is a heterodimer of the proteins S100A8 and S100A9, and it is an abundant innate immune protein associated with inflammation. In humans, calprotectin transcription and protein abundance are associated with asthma and disease severity. Ho
Autor:
Robert M Tighe, Sweta M Patel
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
Smoking and human immunodeficiency virus 1 (HIV-1) infection are risk factors for chronic obstructive pulmonary disease (COPD), which is among the most common comorbid conditions in people living with HIV-1. HIV-1 infection leads to persistent expans
Autor:
Kevin J. Viken, Pratik D. Jagtap, Maneesh Bhargava, Joel D. Rudney, James E. Johnson, Ryan C. Hunter, Thomas McGowan, Kathryn M. Pendleton, Timothy J. Griffin
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 59:648-652
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Pneumonia-induced lung injury and acute respiratory distress syndrome can develop because of an inappropriate inflammatory response to acute infections, leading to a compromised alveolar barrier. Recent work suggests that hospitalized patients with a
Autor:
Sara J Bonvini
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
The mechanisms responsible for the increased loss of pulmonary function following acute lung inflammation in chronic obstructive pulmonary disease remain poorly understood. To investigate this process, our laboratory developed a hamster model that us
Autor:
Nelli Baal, Ingrid Henneke, Grazyna Kwapiszewska, Leigh M. Marsh, Holger Hackstein, Dariusz Zakrzewicz, Marc W. Nolte, de Maat S, Martin Witzenrath, Malgorzata Wygrecka, Ralph T. Schermuly, Werner Seeger, Con Panousis, P. Markart, Lukasz Wujak, Katrin Reppe, Djuro Kosanovic, Miroslava Didiasova, Holger Müller-Redetzky, Helena Frey, Liliana Schaefer, Coen Maas
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 196:186-199
Acute respiratory distress syndrome is characterized by alveolar epithelial cell injury, edema formation, and intraalveolar contact phase activation.To explore whether C1 esterase inhibitor (C1INH), an endogenous inhibitor of the contact phase, may p
Autor:
Tereza Martinu, Stephen C. Juvet
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Am J Respir Cell Mol Biol
Am J Respir Cell Mol Biol
The immune system is designed to robustly respond to pathogenic stimuli but to be tolerant to endogenous ligands to not trigger autoimmunity. Here, we studied an endogenous damage-associated molecular pattern, mitochondrial DNA (mtDNA), during primar
Autor:
Man Jia, Xiaoyi Yan, Yi Yang, Jiayan Xu, Yaqi Meng, Yunhui Wu, Mao Huang, Xinyu Jiang, Xin Yao, Shan Mao, Xiuwedi Zhang, Wei Gu, Peter J. Barnes, Xia Shan, Ian M. Adcock, Stelios Pavlidis
RATIONALE: Bronchial epithelial cell damage occurs in patients with bronchial asthma. Ezrin, a membrane-cytoskeleton protein, maintains cellular morphology and intercellular adhesion and protects the barrier function of epithelial cells. OBJECTIVES:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec9b3b88dcccf94fc0c9dbb9f1c9983
http://hdl.handle.net/10044/1/83705
http://hdl.handle.net/10044/1/83705
Autor:
Jin-Ah Park, Stephanie A. Shore, Joo-Hyeon Lee, Jennifer A. Mitchel, Silvio Antoniak, David I. Kasahara, Elliot Israel, Maureen McGill, Sae Hoon Kim, Nigel Mackman, Scott H. Randell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:524-531
Tissue factor (TF) is best known as a cellular initiator of coagulation, but it is also a multifunctional protein that has been implicated in multiple pathophysiologic conditions, including asthma. In the lung, airway epithelial cells express TF, but