Zobrazeno 1 - 10
of 121
pro vyhledávání: ''
Autor:
Judith M. Vonk, Ilse M. Boudewijn, Siebrig Schokker, Sebastiaan J. Vroegop, Paul Hagedoorn, Henderik W. Frijlink, Maarten van den Berge, Nick H. T. ten Hacken, Anne J. Lexmond, Claire A. Cox
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 197(3), 391-394. AMER THORACIC SOC
Autor:
Rui-hong Do, Sara Reiss, Rasul Abdolrasulnia, Pingsheng Wu, Wei Han, Aimee Hoskins, Ning Chen, Ryszard Dworski
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 187:34-41
Asthma is a heterogeneous lung disorder characterized by airway inflammation and airway dysfunction, manifesting as hyperresponsiveness and obstruction. Glutathione S-transferase M1 (GSTM1) is a multifunctional phase II enzyme and regulator of stress
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 186:493-500
Bronchial hyperresponsiveness (BHR) is an important, but not specific, asthma characteristic.We aimed to assess the predictive value of BHR tested by methacholine and exercise challenge at age 10 years for active asthma 6 years later.From a Norwegian
Autor:
Monica Kraft, Dave Francisco, Jennifer L. Ingram, Mary E. Sunday, Anays Murillo, David Slade, Tony D. Church, Karissa Heck, Njira L Lugogo, Michael Ghio, Loretta G. Que, Rafael Firszt, R. Wesley Sigmon
Elastin synthesis and degradation in the airway and lung parenchyma contribute to airway mechanics, including airway patency and elastic recoil. IL-13 mediates many features of asthma pathobiology, including airway remodeling, but the effects of IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b7fb41d3a02be0f9ee96c2f5cedf26
https://europepmc.org/articles/PMC4742923/
https://europepmc.org/articles/PMC4742923/
Autor:
Yuk-Miu Lam, Athavudh Deesomchok, M. Diane Lougheed, Denis E. O'Donnell, Katherine A. Webb, Josuel Ora, Thomas Fisher
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 181:125-133
The influence of obesity on the perception of respiratory discomfort during acute bronchoconstriction in asthma is unknown.We hypothesized that the respiratory impairment associated with an increased body mass index (BMI) would predispose to greater
Autor:
Brian J. O'Connor, Ashley Woodcock, Sheila Schwartz, Duncan Richards, Dave Singh, Richard G. Knowles, S. J. Langley
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 176:988-993
Exhaled breath nitric oxide (Fe(NO)) is increased in asthma. NO is produced predominantly by inducible nitric oxide synthase (iNOS).We evaluated the selective and potent iNOS inhibitor GW274150 in asthma.Twenty-eight steroid-naive patients with asthm
Autor:
Gilman B. Allen, Ryan J. Norton, Charles G. Irvin, Lennart K. A. Lundblad, John Thompson-Figueroa, Lisa Rinaldi, Jason H. T. Bates
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 175:768-774
Allergically inflamed mice exhibit airway hyperresponsiveness to inhaled methacholine, which computer simulations of lung impedance suggest is due to enhanced lung derecruitment and which we sought to verify in the present study.BALB/c mice were sens
Autor:
Peter J. Sterk, Annelies M. Slats, Joost G. van den Aardweg, Johan C. de Jongste, Kirsten Janssen, Pieter S. Hiemstra, Thais Mauad, Dirk T. van der Plas, Klaus F. Rabe, Annemarie van Schadewijk, Robert Schot
Publikováno v:
American journal of respiratory and critical care medicine, 176(2), 121-128. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 176(2), 121-128. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 176, 121-128. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 176(2), 121-128. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 176, 121-128. American Thoracic Society
Rationale: Deep inspirations provide physiologic protection against airway narrowing in healthy subjects, which is impaired in asthma and chronic obstructive pulmonary disease (COPD). Airway inflammation has been suggested to alter airway mechanics d
Airway Hyperreactivity in Exacerbation of Chronic Asthma Is Independent of Eosinophilic Inflammation
Autor:
Rakesh K. Kumar, Paul S. Foster, Nicole G. Hansbro, Cristan Herbert, Ming Yang, Jessica S. Siegle
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 35:565-570
We have developed an animal model to investigate the mechanisms underlying an acute exacerbation of chronic asthma. Sensitized BALB/c mice were exposed to aerosolized ovalbumin, either as chronic low-level challenge (mass concentration approximately
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 174:15-20
1018 ISS is a synthetic oligonucleotide containing immunostimulatory CpG motifs. In animal studies, 1018 ISS effectively inhibited Th2-mediated lung inflammation, including eosinophil infiltration, and airway hyperresponsiveness.To evaluate whether 1