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pro vyhledávání: ''
Autor:
Brian B. Graham, Katrina Diener, Liya Gebreab, Ewa Kolosionek, Michael G. Edwards, Ted Shade, Jacob J. Chabon, Kenneth L. Jones, Ghazwan Butrous, Rajesh Kumar, Elias Debella, Angela Bandeira, Mark W. Geraci, Rubin M. Tuder, Gao Bi-feng
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:951-959
Schistosomiasis is one of the most common causes of pulmonary arterial hypertension worldwide, but the pathogenic mechanism by which the host inflammatory response contributes to vascular remodeling is unknown. We sought to identify signaling pathway
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:1135-1145
Previous studies of pulmonary arterial hypertension (PAH) have implicated excessive transforming growth factor (TGF)-β1 signaling and reduced bone morphogenetic protein (BMP) signaling in the disease pathogenesis. Reduced BMP signaling in pulmonary
Autor:
Anthony D. Schmitt, Roshini Zachariah, Michael Lanuti, Bryan C. Fuchs, Mari Mino-Kenudson, Yan Yang, Howard H. Chen, Peter Caravan, David E. Sosnovik, Guangping Dai
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:1120-1126
Idiopathic pulmonary fibrosis is a chronic, progressive, fibrosing interstitial pneumonia of unknown cause resulting in dyspnea and functional decline until death. There are currently no effective noninvasive tools to monitor disease progression and
Autor:
Zoya V. Niatsetskaya, Irina Utkina-Sosunova, Sergey A. Sosunov, Veniamin Ratner, Vadim S. Ten
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:943-950
Hyperoxia inhibits pulmonary bioenergetics, causing delayed alveolarization in mice. We hypothesized that mechanical ventilation (MV) also causes a failure of bioenergetics to support alveolarization. To test this hypothesis, neonatal mice were venti
Autor:
Viswanathan Natarajan, Panfeng Fu, Priya Patel, Long Shuang Huang, Yutong Zhao, Joe G.N. Garcia, Anantha Harijith, Tianjiao Sun, Jerold Chun
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:912-922
Idiopathic pulmonary fibrosis is a devastating disease characterized by alveolar epithelial cell injury, the accumulation of fibroblasts/myofibroblasts, and the deposition of extracellular matrix proteins. Lysophosphatidic acid (LPA) signaling throug
Autor:
Catharina van Heusden, Juliana I. Sesma, Lubna H. Abdullah, Lucia Seminario-Vidal, Richard C. Boucher, Carla Ribeiro, Eduardo R. Lazarowski, Seiko F. Okada
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:814-820
ATP in airway surface liquid (ASL) controls mucociliary clearance functions via the activation of airway epithelial purinergic receptors. However, abnormally elevated ATP levels have been reported in inflamed airways, suggesting that excessive ATP in
Autor:
Henry T. Akinbi, John E. Baatz, Joseph A. Kitzmiller, Yan Xu, Kristen Page, Thomas R. Korfhagen, Stephan W. Glasser, Teah L. Ruetschilling, Melissa D. Maxfield, Erik L. Bao
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:845-854
Pulmonary surfactant protein-C (SP-C) gene-targeted mice (Sftpc(-/-)) develop progressive lung inflammation and remodeling. We hypothesized that SP-C deficiency reduces the ability to suppress repetitive inflammatory injury. Sftpc(+/+) and Sftpc(-/-)
Autor:
Alison M. Wallace, Patrick Geraghty, Leo Arellanos, Jeanine D'Armiento, Victor Thompson, Oleg Mirochnitchenko, Robert F. Foronjy, Jincy Thankachen, Andrew A. Hardigan
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:721-730
Protein phosphatase–2A (PP2A) is a primary serine–threonine phosphatase that modulates inflammatory responses in asthma and chronic obstructive pulmonary disease (COPD). Despite its importance, the mechanisms that regulate lung PP2A activity rema
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:798-807
Klebsiella pneumoniae causes serious infections in the urinary tract, respiratory tract, and blood. Lipid rafts, also known as membrane microdomains, have been linked to the pathogenesis of bacterial infection. However, whether lipid rafts affect K.
Autor:
G. R. Scott Budinger, Kristina Kligys, Yvonne Wu, Jonathan C. R. Jones, Kevin J. Hamill, Katherine T. Lewandowski, Susan B. Hopkinson
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:731-740
The repair of the bronchiolar epithelium damaged by cell-mediated, physical, or chemical insult requires epithelial cell migration over a provisional matrix composed of complexes of extracellular matrix molecules, including fibronectin and laminin. T