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Autor:
Brian B. Graham, Katrina Diener, Liya Gebreab, Ewa Kolosionek, Michael G. Edwards, Ted Shade, Jacob J. Chabon, Kenneth L. Jones, Ghazwan Butrous, Rajesh Kumar, Elias Debella, Angela Bandeira, Mark W. Geraci, Rubin M. Tuder, Gao Bi-feng
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:951-959
Schistosomiasis is one of the most common causes of pulmonary arterial hypertension worldwide, but the pathogenic mechanism by which the host inflammatory response contributes to vascular remodeling is unknown. We sought to identify signaling pathway
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:1135-1145
Previous studies of pulmonary arterial hypertension (PAH) have implicated excessive transforming growth factor (TGF)-β1 signaling and reduced bone morphogenetic protein (BMP) signaling in the disease pathogenesis. Reduced BMP signaling in pulmonary
Autor:
Viswanathan Natarajan, Panfeng Fu, Priya Patel, Long Shuang Huang, Yutong Zhao, Joe G.N. Garcia, Anantha Harijith, Tianjiao Sun, Jerold Chun
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:912-922
Idiopathic pulmonary fibrosis is a devastating disease characterized by alveolar epithelial cell injury, the accumulation of fibroblasts/myofibroblasts, and the deposition of extracellular matrix proteins. Lysophosphatidic acid (LPA) signaling throug
Autor:
G. R. Scott Budinger, Kristina Kligys, Yvonne Wu, Jonathan C. R. Jones, Kevin J. Hamill, Katherine T. Lewandowski, Susan B. Hopkinson
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:731-740
The repair of the bronchiolar epithelium damaged by cell-mediated, physical, or chemical insult requires epithelial cell migration over a provisional matrix composed of complexes of extracellular matrix molecules, including fibronectin and laminin. T
Autor:
Michael J. Welsh, Christine L. Wohlford-Lenane, Scott D. Rose, Peng Jiang, Ashley M. Jacobi, Mark A. Behlke, Kim A. Lennox, Philip H. Karp, Yi Xing, Samantha R. Osterhaus, Shyam Ramachandran, Kal Praekh, Paul B. McCray
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:544-551
MicroRNAs (miRNAs) are increasingly recognized as important posttranscriptional regulators of gene expression, and changes in their actions can contribute to disease states. Little is understood regarding miRNA functions in the airway epithelium unde
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:672-679
Cystic fibrosis transmembrane conductance regulator (CFTR) activity is essential for the maintenance of airway surface liquid depth, and therefore mucociliary clearance. Reactive oxygen species, increased during inflammatory airway diseases, alter CF
Autor:
Ragini Vittal, Elizabeth A. Mickler, Amanda J. Fisher, George E. Sandusky, Alyssa Panitch, Oscar W. Cummings, Cynthia Lander, David S. Wilkes, Hongmei Gu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:47-57
Mitogen-activated protein kinase–activated protein kinase–2 (MAPKAPK2, or MK2), a serine/threonine kinase downstream of p38 mitogen–activated protein kinase, has been implicated in inflammation and fibrosis. Compared with pathologically normal
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 48:758-764
Human eosinophils display directed chemotactic activity toward an array of soluble chemokines. Eosinophils have been observed to migrate to draining lymph nodes in experimental models of allergic inflammation, yet it is unknown whether eosinophils ex
Autor:
Ruxana T. Sadikot, Syed Mansoor, Panfeng Fu, Chinnaswamy Tiruppathi, Viswanathan Natarajan, Vijay Mohan
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 48:477-488
Earlier studies indicated a role for reactive oxygen species (ROS) in host defense against Pseudomonas aeruginosa infection. However, the role of nicotinamide adenine dinucleotide phosphate–reduced (NADPH) oxidase (NOX) proteins and the mechanism o
Autor:
Bharathi Aravamudan, Sarah Kay VanOosten, Brent S. Miller, Venkatachalem Sathish, Christina M. Pabelick, Robert Vassallo, Michael A. Thompson, Y. S. Prakash
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 48:431-438
Enhanced airway smooth muscle (ASM) contractility contributes to increased resistance to airflow in diseases such as bronchitis and asthma that occur in passive smokers exposed to secondhand smoke. Little information exists on the cellular mechanisms