Zobrazeno 1 - 10
of 119
pro vyhledávání: ''
Autor:
Jean-Paul Courneya, Rita Fishelevich, Irina G. Luzina, Violeta Rus, Sergei P. Atamas, Brian Hampton, Alexander V. Misharin, Nevins W. Todd, Virginia Lockatell, Tudor C. Badea, Horea Rus
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:146-157
Some previous studies in tissue fibrosis have suggested a profibrotic contribution from elevated expression of a protein termed either Regulator of Cell Cycle (RGCC) or Response Gene to Complement 32 Protein (RGC-32). Our analysis of public gene expr
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses whi
Autor:
Cécile Macquin, Philippe Georgel, Hamid Merdji, Mohamad Kassem, Seiamak Bahram, Kei Kurihara, Aurore De Cauwer, Alicia Sibony, Julie Helms, Chérine Abou Fayçal, Raphaël Clere-Jehl, Laetitia Minniti, Ferhat Meziani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Septic shock and disseminated intravascular coagulation (DIC) are known to be characterized by an endothelial cell dysfunction. The molecular mechanisms underlying this relationship are, however, poorly understood. In this work, we aimed to investiga
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Pulmonary fibrosis is a progressive and fatal lung disease characterized by activation of lung fibroblasts and excessive deposition of collagen matrix. We show here that the concentrations of kindlin-2 and its binding partner PYCR1, a key enzyme for
Autor:
Ji Min Li, Wen Hsin Chang, Ssu-Wei Hsu, Shenwen Gu, David C. Yang, Ching-Hsien Chen, Szu Jung Chen
Publikováno v:
Am J Respir Cell Mol Biol
Tobacco smoking is a well-known risk factor for both fibrogenesis and fibrotic progression; however, the mechanisms behind these processes remain enigmatic. RTKs (receptor tyrosine kinases) have recently been reported to drive profibrotic phenotypes
Autor:
Erica L. Beatman, Christophe Poirier, Danting Cao, Andrew M. Mikosz, Alexandra L. McCubbrey, Irina Petrache, Irina Bronova, Christina F Cornell, Evgeny Berdyshev, Joanna M Poczobutt, Karina A. Serban, Fabienne Gally, François Paris, Kelly S. Schweitzer
Publikováno v:
Am J Respir Cell Mol Biol
Deficiency of ASM (acid sphingomyelinase) causes the lysosomal storage Niemann-Pick disease (NPD). Patients with NPD type B may develop progressive interstitial lung disease with frequent respiratory infections. Although several investigations using
Publikováno v:
Am J Respir Cell Mol Biol
Respiratory disorders are among the most important medical problems threatening human life. The conventional therapeutics for respiratory disorders are hindered by insufficient drug concentrations at pathological lesions, lack of cell-specific target
Autor:
Matthew N. Alder, Amy Opoka, Lin Fei, Al-Faraaz Kassam, Nick C. Levinsky, Patrick Lahni, Hector R. Wong, Jaya P Mallela, Rashmi D Sahay, Kira Angel, Vanessa Nomellini
Publikováno v:
Am J Respir Cell Mol Biol
Neutrophils are vital to both the inflammatory cascade and tissue repair after an injury. Neutrophil heterogeneity is well established but there is less evidence for significant, different functional roles for neutrophil subsets. OLFM4 (Olfactomedin-
Autor:
Mario Boehm, Norbert Weissmann, Danny Jonigk, Friedrich Grimminger, Astrid Weiss, Beate Christiane Schlueter, Clemens Ruppert, Ralph T. Schermuly, Baktybek Kojonazarov, Werner Seeger, Dinesh Yerabolu, Andreas Günther, Hossein Ardeschir Ghofrani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the pulmonary vasculopathy including the obliteration of the lung vasculature that causes an increase in vascular resistance and mean blood pressure in the pulmo
Autor:
Minzhe Guo, Yan Xu, Joseph A. Kitzmiller, Weichen Ouyang, Shuyang Zhao, Yina Du, Jeffrey A. Whitsett
Publikováno v:
Am J Respir Cell Mol Biol