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Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Pulmonary fibrosis is a progressive and fatal lung disease characterized by activation of lung fibroblasts and excessive deposition of collagen matrix. We show here that the concentrations of kindlin-2 and its binding partner PYCR1, a key enzyme for
Autor:
Ji Min Li, Wen Hsin Chang, Ssu-Wei Hsu, Shenwen Gu, David C. Yang, Ching-Hsien Chen, Szu Jung Chen
Publikováno v:
Am J Respir Cell Mol Biol
Tobacco smoking is a well-known risk factor for both fibrogenesis and fibrotic progression; however, the mechanisms behind these processes remain enigmatic. RTKs (receptor tyrosine kinases) have recently been reported to drive profibrotic phenotypes
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
TOLLIP (Toll-interacting protein) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type–specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic-reticulum stress, an ac
Autor:
Yanfang Yu, Kai Li, Li Hu, Dong Wei, Feng Chen, Huijie Huang, Jingyu Chen, Jie Wang, Qing Ye, Fangzhu Wang, Youjia Yu, David Fulton, Bin Shen, Jingjing Ding
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Posttranscriptional modifications are implicated in vascular remodeling of pulmonary hypertension (PH). m6A (N6-methyladenosine) is an abundant RNA modification that is involved in various biological processes. Whether m6A RNA modification
Autor:
Matthew N. Alder, Amy Opoka, Lin Fei, Al-Faraaz Kassam, Nick C. Levinsky, Patrick Lahni, Hector R. Wong, Jaya P Mallela, Rashmi D Sahay, Kira Angel, Vanessa Nomellini
Publikováno v:
Am J Respir Cell Mol Biol
Neutrophils are vital to both the inflammatory cascade and tissue repair after an injury. Neutrophil heterogeneity is well established but there is less evidence for significant, different functional roles for neutrophil subsets. OLFM4 (Olfactomedin-
Autor:
Belinda L. Sun, Sara M. Camp, Heather Lynn, Ankit A. Desai, Xiaoguang Sun, Haiyang Tang, Rebecca Vanderpool, Franz Rischard, Jason X.-J. Yuan, Aleksandra Babicheva, Nancy Casanova, Liliana Moreno-Vinasco, Jian Wang, Geetanjali Gupta, Carrie L. Kempf, Mohamed Ahmed, Joe G.N. Garcia, Saad Sammani, Radu C. Oita, Akash Gupta
Publikováno v:
Am J Respir Cell Mol Biol
We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase) in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and extracellular NAMPT’s (eNAMPT’s) role in PAH vascular remodeling. NAMPT transcr
Autor:
Nickolai O. Dulin, Gabriel Barron, Fangfang Duan, Angelo Y. Meliton, Gökhan M. Mutlu, Lucia Schuger
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 60:221-231
Interstitial lung fibrosis, a frequently idiopathic and fatal disease, has been linked to the increased expression of profibrotic transforming growth factor (TGF)-βs. P311 is an RNA-binding protein that stimulates TGF-β1, -β2, and -β3 translation
Autor:
Lurong Lian, Inkyung Kang, Ning Zuo, Ryan Rue, Melody A. Swartz, Elena N. Atochina-Vasserman, Vera P. Krymskaya, Thomas N. Wight, Andrew J. Gow, Katharina Maisel, Alexander N. Vasserman, Mervyn J. Merrilees, Evgeniy Eruslanov, Luis Angel, Kseniya Obraztsova
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 59:723-732
Pulmonary lymphangioleiomyomatosis (LAM) is a slow-progressing metastatic disease that is driven by mutations in the tumor suppressor tuberous sclerosis complex 1/2 (TSC1/2). Rapamycin inhibits LAM cell proliferation and is the only approved treatmen
Publikováno v:
Annals of the American Thoracic Society
Respiratory tissues are bombarded by billions of particles daily. If allowed to accumulate, these particles can cause injury, inflammation, or infection, and thus may significantly disrupt airflow and gas exchange. Mucociliary defense, a primary mech
Autor:
Kolene E. Bailey, Franziska E. Uhl, Hani N. Alsafadi, Darcy E. Wagner, Melanie Königshoff, Mauricio Rojas, Ricardo H. Pineda
Publikováno v:
Am J Respir Cell Mol Biol
Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial lung disease, and lung cancer, are among the leading causes of morbidity globally and impose major health and financial burdens on patients and society. Effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921ceee68edfedc2a122092563039412
https://europepmc.org/articles/PMC7401444/
https://europepmc.org/articles/PMC7401444/