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Publikováno v:
Annals of the American Thoracic Society
Rationale: A central component of septic shock treatment is the infusion of vasopressors, most commonly starting with norepinephrine. However, the optimal approach and practice patterns to initiati...
Autor:
Xiaoyun Wang, G.L. Kinney, Maor Sauler, Duo Zhang, Michael Tomchaney, Tianshi David Wu, Bartolome R. Celli, Jaroslaw W. Zmijewski, Rick G. Schnellmann, Elizabeth Córdoba-Lanús, Kristan H. Cleveland, Jonathan Mayo, Craig P. Hersh, Judy Tram, John P. Konhilas, Paul R. Langlais, Ciro Casanova, Nadia N. Hansel, Yohannes Tesfaigzi, Samuel Packard, Joselyn Rojas-Quintero, Kevin Doubleday, Ashraf Fawzy, Meredith C. McCormack, Francesca Polverino, Irfan Rahman, Caroline A. Owen, Julie G. Ledford
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Am J Respir Crit Care Med
Am J Respir Crit Care Med
Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation, leading to accelerated lung aging, apoptosis, and emphysema, as well as systemic pathologies. Metformin is beneficial for protecting against aging-related diseases
Autor:
Rosemarie B. Dudenhofer, Pingsheng Wu, Margaret L. Salisbury, Wendi R. Mason, Timothy S. Blackwell, James E. Loyd, Guixiao Ding, Lisa Lancaster, Jonathan A. Kropski, James Del Greco, Susan Martin, Justin C. Hewlett
Publikováno v:
Annals of the American Thoracic Society. 18:1291-1297
Rationale: Human herpesviruses Epstein-Barr virus and cytomegalovirus are frequently detectable in the lungs of patients with idiopathic pulmonary fibrosis (IPF) and could contribute to disease pat...
Autor:
Fernando Torres, Meagan Spychala, Ashley Pinckney, Paul M. Hassoun, Carla D’Aveta, Lynette Keyes-Elstein, David B. Badesch, Mark R. Nicolls, Holden Maecker, Beverly Welch, R. James White, Jerry A. Molitor, Robyn T. Domsic, Dinesh Khanna, Roham T. Zamanian, Lorinda Chung, Thomas A. Medsger, Ellen Goldmuntz, Andrew J. Sweatt
Publikováno v:
Am J Respir Crit Care Med
Rationale: Systemic sclerosis (SSc)–pulmonary arterial hypertension (PAH) is one of the most prevalent and deadly forms of PAH. B cells may contribute to SSc pathogenesis. Objectives: We investigated the safety and efficacy of B-cell depletion for
Autor:
Christian Bode, Stilla Frede, Konrad Peukert, Hermann Wrigge, Christian Putensen, Benjamin Seeliger, Tobias Welte, Eicke Latz, Beate M. Kümmerer, Folkert Steinhagen, Caroline Feuerborn, Dennis M. Klinman, Mario Fox, Susanne Schulz, Christoph Wilhelm, Sascha David
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 204:53-63
Rationale: Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with a mortality of up to 40%. Precision medicine approaches targeting patients on the basis of their molecular phenotypes of ARDS might help to identify effective phar
Autor:
Klaus Uwe Kirchgaessler, Toby M. Maher, Mark Atwood, Philip L. Molyneaux, Derek Weycker, Argyrios Tzouvelekis, Justin M. Oldham, Michael Kreuter, Joyce S. Lee
Publikováno v:
American journal of respiratory and critical care medicine, vol 204, iss 1
Rationale: There is an urgent need for simple, cost-effective prognostic biomarkers for idiopathic pulmonary fibrosis (IPF); biomarkers that show potential include monocyte count. Objectives: We used pooled data from pirfenidone and interferon gamma-
Autor:
Pierre-Régis Burgel, Isabelle Durieu, Raphaël Chiron, Sophie Ramel, Isabelle Danner-Boucher, Anne Prevotat, Dominique Grenet, Christophe Marguet, Martine Reynaud-Gaubert, Julie Macey, Laurent Mely, Annlyse Fanton, Sébastien Quetant, Lydie Lemonnier, Jean-Louis Paillasseur, Jennifer Da Silva, Clémence Martin, Claire Andrejak, Arnaud Becourt, Julie Mounard, Claire Poulet, Cinthia Rames, Marie Talleux, Marie-Chantal Chevalier, Estelle Darviot, Marie Jouvenot, Caroline Marien, Audrey Paris, Cécile Pelatan, Christine Person, Pascaline Priou, Françoise Troussier, Thierry Urban, Marie-Laure Dalphin, Jean-Charles Dalphin, Alice Ladaurade, Didier Pernet, Bénédicte Richaud-Thiriez, Pauline Roux-Claude, Nathalia Blanc, Vincent Boisserie-Lacroix, Stephanie Bui, Cyrielle Collet, Stéphane Debelleix, Emmanuel Bergot, Jacques Brouard, Karine Campbell, Muriel Laurans, Virginie Ribault, Corinne Borderon, Marie-Christine Heraud, Guillaume Labbe, Sylvie Montcouquiol, Isabelle Petit, Marc Ruivard, Céline Delestrain, Benoit Douvry, Ralph Epaud, Bernard Maitre, Natascha Remus, Guillaume Beltramo, Anne Houzel, Frédéric Huet, Stéphanie Perez, Amale Boldron-Ghaddar, Manuela Scalbert, Rabah Bouzioukh, Charles Simon, Boubou Camara, Rébecca Hamidfar, Catherine Llerena, Isabelle Pin, Antoine Deschildre, Alice Gicquello, Olivier Le Rouzic, Clara Leroy, Nicolas Paris, Thierry Perez, Caroline Thumerelle, Dominique Turck, Nathalie Wizla, Magali Dupuy-Grasset, Jane Languepin, Alexandra Masson-Rouchaud, Céline Menetrey, Stéphane Durupt, Sophie L’Excellent, Raphaele Nove-Josserand, Camille Ohlmann, Phillipe Reix, Quitterie Reynaud, Marie-Christine Werck-Gallois, Mélissandre Baravalle, Bérangère Coltey, Nadine Desmazes-Dufeu, Jean-Christophe Dubus, Clarisse Gautier, Jean-Baptiste Rey, Nathalie Stremler, Davide Caimmi, Margot Devrait, Johan Moreau, Yves Billon, Aurore Blondé, Anne Guillaumot, Sébastien Kiefer, Laura Peretti, Aurélie Tatopoulos, Angélica Tiotiu, Myriam Benhamida, Tiphaine Bihouee, Emmanuel Eschapasse, Adrien Tissot, Marie Giannantonio, Sylvie Leroy, Carole Piccini-Bailly, Johana Pradelli, Jonathan Messika, Véronique Boussaud, Nicolas Carlier, Isabelle Honoré, Dominique Hubert, Reem Kanaan, Céline Bailly-Botuha, Frédérique Chedevergne, Jacques De Blic, Christophe Delacourt, David Drummond, Brigitte Fauroux, Chantal Karila, Muriel Le Bourgeois, Isabelle Sermet, Bertrand Delaisi, Michèle Gerardin, Veronique Houdouin, Laurence Leclainche, Guillaume Aubertin, Laura Berdah, Annick Clement, Harriet Corvol, Nadia Nathan, Blandine Prevost, Nicolas Richard, Aline Tamalet, Jessica Taytard, Guillaume Thouvenin, Barbara Tourniaire, Michel Abely, Katia Bessaci-Kabouya, Sandra Dury, Bruno Ravoninjatovo, Alain Dabadie, Michel Dagorne, Eric Deneuville, Marie Jamin, Mélanie Ribault, Clémentine Vigier, Chantal Belleguic, Graziella Brinchault, Benoit Desrues, Audrey Barzic, Anne Dirou-Prigent, Jean Le Bihan, Krista Revert, Thomas Ropars, Laure Couderc, Stéphane Dominique, Hélène Morisse-Pradier, Stéphanie Pramil, Luc Thiberville, Nathalie Allou, Laurent Enaud, Elsa Gachelin, Eric Huchot, Annabelle Payet, Caroline Perisson, Saguiraly Piyaraly, Sophie Valois, Audrey Herzog, Romain Kessler, Michele Porzio, Laurence Weiss, Laurence Beaumont, Olivier Brugiere, Sylvie Colin, de Verdiere, Elise Cuquemelle, Sandra De Miranda, Adbdul Monem Hamid, François Parquin, Clément Picard, Antoine Roux, Charlotte Roy, François Bremont, Alain Didier, Marion Dupuis, Guillaume Faviez, Géraldine Labouret, Marie Mittaine, Marlène Murris-Espin, Léa Roditis, Laure Cosson, Patrice Diot, Thomas Flament, Charlotte Giraut, Julie Mankikian, Baptiste Arnouat, Gaétane Mousset, Véronique Storni, Philippe Vigneron, Emmanuelle Coirier-Duet, Asma Gabsi
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2021, 204 (1), pp.64-73. ⟨10.1164/rccm.202011-4153OC⟩
American Journal of Respiratory and Critical Care Medicine, 2021, 204 (1), pp.64-73. ⟨10.1164/rccm.202011-4153OC⟩
International audience; Rationale: Elexacaftor-tezacaftor-ivacaftor is a CFTR (cystic fibrosis [CF] transmembrane conductance regulator) modulator combination, developed for patients with CF with at least one Phe508del mutation. Objectives: To evalua
Publikováno v:
Annals of the American Thoracic Society
Many patients with obstructive sleep apnea (OSA) experience excessive daytime sleepiness (EDS), which can negatively affect daily functioning, cognition, mood, and other aspects of well-being. Although EDS can be reduced with primary OSA treatment, s
Autor:
Daniel Campbell, Claire E. Wainwright, Christopher Harris, Jane C. Davies, Gregory S. Sawicki, Mark Higgins, Margaret Rosenfeld, S. Tian, Paul Panorchan, Eric L. Haseltine
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: We previously reported that ivacaftor was safe and well tolerated in cohorts aged 12 to 3 to ≤5× the upper limit of normal at Week 24. No other adverse trends in laboratory tests, vital signs, or ECG parameters were reported. Sweat chlo
Autor:
Malena Cohen-Cymberknoh, Eitan Kerem, Michael Wilschanski, Alex Gileles-Hillel, Christopher Short, C DeSouza, Thea Pugatsch, Reuven Tsabari, Clare Saunders, Joel Reiter, James C. Sullivan, N. Kinnman, David Shoseyov, Jane C. Davies, Jamie R Doyle, Keval Chandarana
Publikováno v:
Annals of the American Thoracic Society. 18:433-441
Rationale: Ivacaftor's clinical effects in the residual function mutations 3849+10kb C →T and D1152H warrant further characterization. Objectives: Evaluate ivacaftor's effect in people with cystic fibrosis aged ≥6 years with 3849+10kb C→T or D1