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Autor:
Mario Boehm, Norbert Weissmann, Danny Jonigk, Friedrich Grimminger, Astrid Weiss, Beate Christiane Schlueter, Clemens Ruppert, Ralph T. Schermuly, Baktybek Kojonazarov, Werner Seeger, Dinesh Yerabolu, Andreas Günther, Hossein Ardeschir Ghofrani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the pulmonary vasculopathy including the obliteration of the lung vasculature that causes an increase in vascular resistance and mean blood pressure in the pulmo
Autor:
Zaid Shakir, Steven M. Dudek, C M Aldaz, A. Moshensky, Viswanathan Natarajan, Jeffrey R. Jacobson, Weiguo Chen, Lorraine B. Ware, Sunit Singla, Raheel Khan, Laura E. Crotty Alexander, Roberto Machado, Zhenguo Zeng
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:89-99
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are largely unkn...
Autor:
Abdul K. Parchur, Brianna Entringer, Teresa Michalkiewicz, Girija G. Konduri, Ru-Jeng Teng, Amit Joshi, Ujala Rana, Emily Callan
Publikováno v:
Am J Respir Cell Mol Biol
Decreased angiogenesis contributes to persistent pulmonary hypertension of the newborn (PPHN); mechanisms remain unclear. AMPK (5′AMP activated protein kinase) is a key regulator of cell metabolism. We investigated the hypothesis that a decrease in
Autor:
Tao Sun, Jay K. Kolls, Wei Chen, Kong Chen, Annabel A. Ferguson, Joseph M. Pilewski, Yale Jiang, Zhe Sun
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 61:643-652
Ivacaftor is a drug that was recently approved by the U.S. Food and Drug Administration for the treatment of patients with cystic fibrosis (CF) and at least one copy of the G511D mutation in the CFTR (CF transmembrane conductance regulator) gene. The
Autor:
Angeles Fernandez-Gonzalez, Nicolas Christodoulou, Laura E. Fredenburgh, Helen Christou, Paul B. Dieffenbach, Hannes Hudalla, Gareth R. Willis, Evgenia J. Filatava, Zoe Michael, Robert S. Stearman, Mark W. Geraci, Stella Kourembanas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition induces mild metabolic acidosis and exerts protective effects in hypoxic
Autor:
Sanja Stanojevic, Xiayi Ma, Jenna Sykes, Anne L. Stephenson, Adele Coriati, Christopher R. Kawala
Publikováno v:
TP32. TP032 EPIDEMIOLOGY, BIOMARKERS, AND THERAPY IN CF AND NON-CF BRONCHIECTASIS.
Ivacaftor is a CFTR potentiator with demonstrated efficacy in clinical trials and has been rapidly adopted within the CF community. Given the uptake of ivacaftor in eligible people, identifying a comparator group not on modulators to measure effectiv
Autor:
R. Stokes Peebles, Matthew T. Stier
Publikováno v:
Annals of the American Thoracic Society. 15:S205-S209
Respiratory syncytial virus (RSV) is a leading cause of hospitalization of infants worldwide each year. Both host and viral factors host factors predispose a subset of what appear to be healthy infants to severe RSV-induced disease. In this review, w
Autor:
Bradley W. Richmond, Marshall Guo, John T. Benjamin, Rui-Hong Du, Linda A. Gleaves, Timothy S. Blackwell, Riet van der Meer, Vasiliy V. Polosukhin, Austin McKissack, Dong-Sheng Cheng, Wei Han, Yongqin Zhang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:736-744
Loss of secretory IgA is common in the small airways of patients with chronic obstructive pulmonary disease and may contribute to disease pathogenesis. Using mice that lack secretory IgA in the airways due to genetic deficiency of polymeric Ig recept
Autor:
Marcos C. Schechter, Russell R. Kempker, Matthew J. Magee, Argita D. Salindri, Lauren E DiMiceli, Rose-Marie F. Sales
Publikováno v:
Annals of the American Thoracic Society. 15:331-340
Rationale: Isoniazid-monoresistant tuberculosis (INH-monoresistant TB) is the most common drug-resistant TB type in the United States; however, its impact on TB treatment outcomes is not clear. Objectives: This study aims to understand 1) factors ass
Autor:
Judith M. Vonk, Ilse M. Boudewijn, Siebrig Schokker, Sebastiaan J. Vroegop, Paul Hagedoorn, Henderik W. Frijlink, Maarten van den Berge, Nick H. T. ten Hacken, Anne J. Lexmond, Claire A. Cox
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 197(3), 391-394. AMER THORACIC SOC