Zobrazeno 1 - 9
of 9
pro vyhledávání: '"G. Wei Xu"'
Autor:
Fieke W Hoff, Marcela Gronda, Jonathan St-Germain, Rose Hurren, G. Wei Xu, Changjiang Xu, Terzah M. Horton, Steven M. Kornblau, Yulia Jitkova, Xiaoming Wang, Andrea Arruda, Neil MacLean, Steven M. Chan, Sara Mirali, Boaz Nachmias, Yihua Qiu, David Sharon, Aaron D. Schimmer, Gary D. Bader, Veronique Voisin, Botham Aaron, Mark D. Minden, Brian Raught
Publikováno v:
Blood. 134:729-729
Acute myeloid leukemia (AML) cells and stem cells have unique mitochondrial characteristics with an increased reliance on oxidative phosphorylation (OXPHOS). To identify new biological vulnerabilities in the mitochondrial proteome of AML cells, we co
Autor:
Veronique Voisin, G. Wei Xu, Neil MacLean, Gary D. Bader, Rose Hurren, Ayesh K. Seneviratne, Aaron D. Schimmer, Boaz Nachmias, Xioaming Wang, Changjiang Xu, Liran I. Shlush
Publikováno v:
Blood. 134:2530-2530
Patients with relapsed AML (Acute Myeloid Leukemia) have a poor prognosis and few therapeutic options. Therefore, it remains critical to identify biological vulnerabilities in relapsed AML cells. To identify such vulnerabilities, we analyzed mRNA exp
Autor:
Zachary Blatman, Rose Hurren, Aaron D. Schimmer, Geethu E. Thomas, Samir H. Barghout, Neil MacLean, G. Wei Xu
Publikováno v:
Blood. 132:1350-1350
UBA1 is the major ubiquitin-activating enzyme that initiates the ubiquitylation cascade whereby proteins are tagged with mono- or polyubiquitin to mark them for proteasomal degradation or modify their functions. Despite having equal levels of UBA1 pr
Autor:
Rose Hurren, Mark D. Minden, Michael Milhollen, Neil MacLean, Danny V. Jeyaraju, Xiaoming Wang, Samir H. Barghout, Aaron D. Schimmer, G. Wei Xu, Marcela Gronda, Marc L. Hyer, Michael Sintchak, Parasvi S. Patel, Simon Kavanagh, Tary Traore, Allison Berger, Razq Hakem
Publikováno v:
Blood. 130:814-814
Introduction: Ubiquitin-like Modifier Activating Enzyme 1 (UBA1; UAE) is the initiating enzyme in the ubiquitylation cascade in which proteins are tagged with ubiquitin moieties to regulate their degradation or function. Compared to normal hematopoie
Autor:
Khuchua Zaza, Danny V. Jeyaraju, Mingjing Xu, Neil MacLean, Ayesh K. Seneviratne, Zhenyue Hao, Juan J. Aristizabal Henao, Rose Hurren, Steven M. Claypool, Xioaming Wang, Paul J. LeBlanc, Raphaël Chouinard-Watkins, Aaron D. Schimmer, Val Fajado, Ken D. Stark, Richard P. Bazinet, G. Wei Xu, Sejin Kim, Marcela Gronda, Caitlin Schafer
Publikováno v:
Blood. 130:788-788
AML cells have unique mitochondrial characteristics with an increased reliance on mitochondrial metabolism and oxidative phosphorylation. To identify new biological vulnerabilities in the mitochondria of AML, we conducted a CRISPR knockout screen. CA
Autor:
Xiaoming Li, Marko Skrtic, Reza Beheshti Zavareh, Sirano Dhe-Paganon, Tabitha E. Wood, John C. Reed, Marcela Gronda, Derek Wong, Neil MacLean, Rose Hurren, Xinliang Mao, Troy Ketela, Jason Moffat, Meenakshi Venkatesan, David R. Rose, G. Wei Xu, Xiaoming Wang, Robert A. Batey, Mohsin Ali, Aaron D. Schimmer
The proteasomal pathway of protein degradation involves 2 discrete steps: ubiquitination and degradation. Here, we evaluated the effects of inhibiting the ubiquitination pathway at the level of the ubiquitin-activating enzyme UBA1 (E1). By immunoblot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167fe70a4f879e46c72969abe6914960
https://europepmc.org/articles/PMC2920204/
https://europepmc.org/articles/PMC2920204/
Autor:
G. Wei Xu, Julia I. Toth, Sara R. da Silva, Stacey-Lynn Paiva, Julie L. Lukkarila, Rose Hurren, Neil Maclean, Mahadeo A. Sukhai, Rabindra N. Bhattacharjee, Carolyn A. Goard, Bruno C Medeiros, Patrick T. Gunning, Sirano Dhe-Paganon, Matthew D. Petroski, Aaron Schimmer
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93530 (2014)
PLoS ONE
PLoS ONE
The NEDD8-activating enzyme (NAE) initiates neddylation, the cascade of post-translational conjugation of NEDD8 onto target proteins. Cullin proteins are major substrates of the neddylation pathway, and are involved in diverse cellular processes. MLN
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Akademický článek
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