Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ping Zhang"'
Autor:
John D. Belcher, Julia Nguyen, Kristine Nachbor, Zachary Monroe Kiser, Dormarie Rivera-Rodriguez, Jacob Lloyd, Chunsheng Chen, Fuad Abdulla, Rachel Kirchner, Gregory M. Vercellotti, Ping Zhang
Publikováno v:
Blood. 134:3555-3555
We have previously shown that heme, a damage-associated molecular pattern (DAMP), released from sickle RBCs interacts with the innate immune toll-like receptor 4 (TLR4) on endothelium and blood cells to activate cell signaling. This activates the pro
Autor:
Zachary Monroe Kiser, Ping Zhang, Julia Nguyen, Gregory M. Vercellotti, John O. Trent, John D. Belcher
Publikováno v:
Blood. 134:209-209
Lipopolysaccharide (LPS), the first-identified TLR4 agonist, binds myeloid differentiation factor-2 (MD-2) in association with TLR4 to initiate TLR4 signaling. LPS binds to a large hydrophobic pocket in MD-2 and directly bridges the MD-2/TLR4 heterod
Publikováno v:
Blood. 104:1733-1739
The majority of cases of human hemophilia B are the result of missense mutations in the coagulation factor IX gene and defective circulating factor IX is detectable in most patients. The available mouse factor IX knockout models of hemophilia B (FIXK
Autor:
John D. Belcher, Fuad Abdulla, Gregory M. Vercellotti, Nicholas J. Slipek, Pauline Xu, Chunsheng Chen, Minh Nguyen, Julia Nguyen, Ping Zhang, Phong Nguyen
Publikováno v:
Blood. 124:219-219
Patients with sickle cell disease have unrelenting hemolysis leading to the release of hemoglobin and heme into the vasculature that promote oxidative stress, inflammation, vaso-occlusive pain crises, ischemia-reperfusion injury and organ damage. Ind
Autor:
Baoan Chen, Guohua Xia, Lu Cheng, Peipei Xu, Miaoxin Peng, Xiao-Ping Zhang, Zuhong Lu, Ziying Jian
Publikováno v:
Blood. 120:5130-5130
Abstract 5130 Background & Aim: This study detected three single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene in five hematology malignant cell lines, to find correlations between MTHFR gene SNPs and hematologic
Publikováno v:
Blood. 118:517-517
Abstract 517 Extracellular signal-regulated kinase (ERK 1 and 2) are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in multiple cell lineages, including T cells, B cells and osteoblasts. Macrophages
Autor:
Akil Merchant, Sarah Brennan, William Matsui, Ping Zhang, Qiuju Wang, Giselle Joseph, Shyam Biswal, Anju Singh
Publikováno v:
Blood. 114:1492-1492
Abstract 1492 Poster Board I-515 Previous studies have established an important role for reactive oxygen species (ROS) in regulating the function and life-span of hematopoietic stem cells (HSC). Nuclear factor erythroid-2–related factor 2 (Nrf2) is
Publikováno v:
Blood. 106:5526-5526
A major concern regarding the safety of gene therapy for protein deficiencies, including hemophilia, is the possibility of immune responses against the therapeutic transgenic protein. We have previously reported the use of hemophilic mice expressing