Zobrazeno 1 - 10
of 2 018
pro vyhledávání: '"11"'
Autor:
Alexa J. Siddon, Thomas Prebet, Scott F. Huntington, Jan Philipp Bewersdorf, Stephanie Halene, Francine M. Foss, Noffar Bar, Natalia Neparidze, Amer M. Zeidan, Rory M. Shallis, Iris Isufi, Terri L. Parker, Nikolai A. Podoltsev, Stuart Seropian, Tae Kon Kim, Manoj M. Pillai, Steven D. Gore, Autumn DiAdamo, Lohith Gowda
Publikováno v:
Blood. 134:5174-5174
Introduction: Isolated trisomy 11 is a rare, poorly characterized cytogenetic abnormality in myeloid neoplasms (MN) with only a few case series published. Prior reports suggested a lower response rate to standard treatments such as intensive chemothe
Publikováno v:
Blood. 110:4997-4997
Interleukin 11 (IL11) has been approved for clinical utilization by Chinese Drug and Food Administration in the treatment of thrombopenia post chemo/radio therapy. It has been proved a safe cytokine in previous clinical trials. We however found a cas
Autor:
Michael Andreeff, Peter McLaughlin, Yang Huh, Andreas H. Sarris, Ugo Consoli, Susan Starry, Alma Rodriguez, Fernando Cabanillas, Anas Younes
Publikováno v:
Blood. 87:1698-1703
The growth stimulatory effects of interleukin-3 (IL-3) on normal hematopoietic progenitor cells are well established, and clinical trials using IL-3 after bone marrow transplantation for various malignancies including lymphomas are frequently conduct
Autor:
Jeffrey M. Weinberg, Bernice M. Benoit, Christine Jaworsky, Alain H. Rook, Stuart R. Lessin, Brett Telegan
Publikováno v:
Blood. 86:4257-4262
EZARY CELLS are lymphocytes with hyperconvoluted or cerebriform nuclear contours. Morphologically, they are characterized by a high nucleus-to-cytoplasm ratio, deep and narrow nuclear indentations, condensed chromatin at the nuclear membrane, and cyt
Autor:
A M Smith, Linda M. Pilarski, P L Bergsagel, Michael J. Mant, Andrew R. Belch, Agnieszka J. Szczepek
Publikováno v:
Blood. 85:436-447
Multiple myeloma (MM) is characterized by a plasma cell infiltrate of the bone marrow (BM). However, late-stage monotypic B cells have been detected in the blood. This work analyzes the effects of clinical treatment on late stage CD19+ B cells presen
Publikováno v:
Blood. 104:1896-1896
Among the various chromosomal translocations found in pediatric pre-B cell acute leukemias, the t (4; 11) group contains patients of all ages as well as a clustering of children at birth or in the first year of life. As with all 11q23 abnormalities,
Autor:
K Mise, A Horikoshi, Motomichi Sasaki, M Musashi, Y Sato, S Abe, K Kouda, Y Minami, N Kamada, Y Saburi
Publikováno v:
Blood. 70:1654-1658
A reciprocal translocation involving the short arms of chromosomes 7 and 11, t(7;11)(p15;p15), was found in nine patients including eight with acute myelogenous leukemia (AML) and one with Philadelphia (Ph1) chromosome-positive chronic myelogenous le
Publikováno v:
Blood. 59:96-99
Banded bone marrow chromosome analyses have been done on 83 unselected patients with acute lymphoblastic leukemia (ALL). Seven patients, all with non-T, non-B ALL, had a translocation involving the long arms of chromosomes 4 and 11. Five of these pat
Autor:
Owen N. Witte, Susana C. Raimondi, Steven S. Clark, Lois W. Dow, Naoki Tachibana, Stephen J. Lauer
Publikováno v:
Blood. 73:1291-1297
We studied the relationship of direct karyotypes, determined at diagnosis and remission, to Abelson-related tyrosine kinase activity and the cytogenetic features of erythroid and myeloid colonies derived from remission marrow of six children with acu
Autor:
Craig C. Hofmeister, Lawrence H. Boise, Ryosuke Shirasaki, Jonathan L. Kaufman, Nisha Joseph, Benjamin G. Barwick, David L. Jaye, Jonathan J Keats, Constantine S. Mitsiades, Leonard T. Heffner, Benjamin Oberlton, Ajay K. Nooka, Vikas Gupta, Sagar Lonial, Shannon M. Matulis, Madhav V. Dhodapkar
Publikováno v:
Blood. 137:3604-3615
Venetoclax is a highly potent, selective BCL2 inhibitor capable of inducing apoptosis in cells dependent on BCL2 for survival. Most myeloma is MCL1-dependent; however, a subset of myeloma enriched for translocation t(11;14) is codependent on BCL2 and