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Publikováno v:
Blood. 138:2244-2255
Internal tandem duplication within FLT3 (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and correlates with a poor prognosis. Whereas the FLT3 receptor tyrosine kinase is activated at the plasma membrane to transduce
Autor:
David Yudovich, Agatheeswaran Subramaniam, Roman A. Zubarev, Roman Galeev, Jonas Larsson, Alexandra Bäckström, Massimiliano Gaetani, Mayur Vilas Jain, Jun Chen, Kristijonas Žemaitis, Mehrnaz Safaee Talkhoncheh, Shubhranshu Debnath
Publikováno v:
Blood
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a rapid expans
Autor:
Bhanu Kanth Manne, Xiao He, Frederik Denorme, Neal D. Tolley, Wenwen Jia, Alicia S Eustes, Yasuhiro Kosaka, Ben Bolingbroke, Andrew S. Weyrich, Matthew T. Rondina, Krystin Krauel, Sikui Shen, Li Guo, Elizabeth A. Middleton, Craig N. Morrell, Shancy Petsel Jacob, Jesse W. Rowley, Samuel M. Brown, Kyra N. McComas, Robert A. Campbell
Publikováno v:
Blood
Circulating platelets interact with leukocytes to modulate host immune and thrombotic responses. In sepsis, platelet-leukocyte interactions are increased and have been associated with adverse clinical events, including increased platelet–T-cell int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929b000b466f1dda1fa6117dc38e3440
https://europepmc.org/articles/PMC8343546/
https://europepmc.org/articles/PMC8343546/
Autor:
John G. Doench, Michele Moschetta, Antonio Sacco, Yawara Kawano, Yuji Mishima, Aldo M. Roccaro, Franziska Michor, Jiantao Shi, Yu-Tzu Tai, Brianna Berrios, Yujia Shen, David E. Root, Salomon Manier, Robert A. Redd, Francois Mercier, Nang Kham Su, David T. Scadden, Irene M. Ghobrial, Romanos Sklavenitis-Pistofidis
Publikováno v:
Blood
Clonal evolution drives tumor progression, dissemination, and relapse in multiple myeloma (MM), with most patients dying of relapsed disease. This multistage process requires tumor cells to enter the circulation, extravasate, and colonize distant bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe2e79ff2702f0cffcba6dc4eb309ed
https://europepmc.org/articles/PMC8085483/
https://europepmc.org/articles/PMC8085483/
Autor:
Yanzhong Yang, Han Zhang, Yudao Shen, Le Xuan Nguyen, Chun-Wei Chen, Markus Müschen, Yi-Chun Lin, Xianwei Chen, Weili Sun, Hanying Wang, Nadia Carlesso, Jie Sun, Wenjuan Jiang, Xin He, Marina Konopleva, Guido Marcucci, Jian Jin, Haojie Dong, Lei Zhang, Ling Li, Zhihao Wang, Min Li, Yinghui Zhu, Yun Luo, Jianjun Chen
Publikováno v:
Blood
Relapse remains the main cause of MLL-rearranged (MLL-r) acute lymphoblastic leukemia (ALL) treatment failure resulting from persistence of drug-resistant clones after conventional chemotherapy treatment or targeted therapy. Thus, defining mechanisms
Autor:
Chelsea L. Dieck, Adolfo A. Ferrando
Publikováno v:
Blood
Mutations in the cytosolic 59 nucleotidase II (NT5C2) gene drive resistance to thiopurine chemotherapy in relapsed acute lymphoblastic leukemia (ALL). Mechanistically, NT5C2 mutant proteins have increased nucleotidase activity as a result of altered
Autor:
Gavin R. Lloyd, Ugo Scarpa, Andrew D. Southam, Barbara Martins da Costa, Orli Yogev, Vanessa Tubb, Carmela De Santo, Silvia Panetti, Livingstone Fultang, Steven P. Lee, Andris Jankevics, Sarah Booth, Louis Chesler, Warwick B. Dunn, Victoria Stavrou, Francis Mussai
Publikováno v:
Blood
Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine microenvironment also impairs chimeric antigen receptor T cells (CAR-T) cell proliferation, limiting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a99a6e5d4ec34ec171f318b81069e40
https://europepmc.org/articles/PMC7565134/
https://europepmc.org/articles/PMC7565134/
Autor:
Ivan Martin, Fabian Rudolf, Paul Bourgine, Oliver Hilsenbeck, Weijia Wang, Timm Schroeder, Dirk Loeffler, Alois Hopf
Publikováno v:
Blood. 131:1425-1429
Keeping track of individual cell identifications is imperative to the study of dynamic single-cell behavior over time. Highly motile hematopoietic stem and progenitor cells (HSPCs) migrate quickly and do not adhere, and thus must be imaged very frequ
Publikováno v:
Blood. 128:1701-1710
The promoter-proximal pausing of RNA polymerase II (Pol II) plays a critical role in regulating metazoan gene transcription. Despite the prevalence of Pol II pausing across the metazoan genomes, little is known about the in vivo effect of Pol II paus
Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication
Autor:
Xiaoyan Feng, Gang An, Chirag Acharya, Yu-Tzu Tai, Nikhil C. Munshi, Lugui Qiu, Mike Zhong, Li Zhang, Kenneth Wen, Kenneth C. Anderson
Publikováno v:
Blood. 128:1590-1603
Purpose: The number and activity of osteoclasts (OCs) are strongly enhanced by myeloma cells, leading to significant bone lesion in patients with multiple myeloma (MM). Mechanisms remain elusive whether myeloma-supporting OCs also induce suppressive