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Autor:
Paul Milne, Helen J. Blair, Cornelia Eckert, Zoya Kingsbury, Matthew Collin, Anetta Ptasinska, Alex Elder, Roderick Skinner, Janine Stutterheim, Jennifer Becq, Elena Zerkalenkova, Constanze Bonifer, Denis M. Schewe, Peter N. Cockerill, N Martinez-Soria, Oskar A. Haas, Peter Carey, Katarzyna Szoltysek, Deepali Pal, Hesta McNeill, Claus Meyer, Maria Rosaria Imperato, James C. Mulloy, Mark Wunderlich, Catherine Cargo, Paul Evans, Sarah E. Fordham, Shan Lin, Pierre Cauchy, Y Shi, Simon Bailey, Salam A. Assi, Rolf Marschalek, Josef Vormoor, Olaf Heidenreich, A Komkov, Michael J. Thirman, Simon Bomken, Ricky Tirtakusuma, Sirintra Nakjang, Fotini Vogiatzi, James M. Allan, Lisa J. Russell, Jayne Y. Hehir-Kwa, Muzlifah Haniffa, Yulia Olshanskaya, Vasily V. Grinev, Christine J. Harrison, Venetia Bigley, Daniel Williamson, Alex Smith, Natalia Miakova
Publikováno v:
Blood. 140:1875-1890
The fusion gene MLL-AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. However, relapse can be associated with a switch from acute lymphoblastic to acute myeloid leukaemia. Here we show that these myeloid relapses share oncogene
Autor:
Lauren Schaff, Christian Grommes
Publikováno v:
Blood. 140:971-979
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or vitreoretinal space, without evidence of systemic involvement. The diagnosis of PCNSL requires a high
Publikováno v:
Blood
As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is
Publikováno v:
Blood. 139:2130-2144
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat invading pathogens while, at the same time, limiting host tissue injury or autoimmunity. The underlying mechanisms regulatin
Autor:
Zhiwen Wu, Toshiaki Yoshikawa, Yusuke Takahashi, Satoshi Inoue, Hirokazu Matsushita, Hitomi Kasuya, Hiroaki Kuroda, Yuki Kagoya, Shiro Suzuki, Waki Hosoda
Publikováno v:
Blood. 139:2156-2172
Adoptive cancer immunotherapy can induce objective clinical efficacy in patients with advanced cancer; however, a sustained response is achieved in a minority of cases. The persistence of infused T cells is an essential determinant of a durable thera
Autor:
Robert K. Bradley, Patrick Nugent, Khrystyna North, Jasmine Naru, Eunhee Kim, Janine O. Ilagan, Joseph Pangallo, Sergei Doulatov, Martina Sarchi, Derek L. Stirewalt, Arvind R. Subramaniam, Rochelle Bergantinos, Massiel Chavez Stolla, Omar Abdel-Wahab, Janis L. Abkowitz, Courtnee Clough
Publikováno v:
Blood. 139:2038-2049
SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes (MDS) with ring sideroblasts (RS), a clonal hematopoietic disorder characterized by abnormal erythroid cells with iron-loaded mitochondria. Despite this remarkabl
Autor:
Markus G. Manz, Dirk Loeffler, Arne Wehling, Florin Schneiter, Tobias Kull, Claudia Lengerke, Timm Schroeder, Weijia Wang
Publikováno v:
Blood, 139 (13)
Blood
Blood
Understanding human hematopoietic stem cell fate control is important for its improved therapeutic manipulation. Asymmetric cell division, the asymmetric inheritance of factors during division instructing future daughter cell fates, was recently desc
Publikováno v:
Blood. 139:1973-1986
Disseminated intravascular coagulation (DIC) is a syndrome triggered by infectious and noninfectious pathologies characterized by excessive generation of thrombin within the vasculature and widespread proteolytic conversion of fibrinogen. Despite div
Autor:
Ulrich Jaeger, Edit Porpaczy
Publikováno v:
Blood. 139:1479-1488
Autoimmune conditions can occur in a temporary relationship with any malignant lymphoma. In many instances, treatment at diagnosis is not required, but symptomatic autoimmune conditions represent an indication for treatment, particularly in chronic l
Autor:
Yandan Yang, Sigrid Dubois, Takashi Ishio, Takanori Teshima, Shinya Tanaka, Emmanuel Bachy, Masao Nakagawa, Satoshi Hashino, Yibin Yang, Sarvesh Kumar, Yutaka Hatanaka, Anusara Daenthanasanmak, Joji Shimono, Tomoyuki Endo, Patrick L. Green, Bonita R. Bryant, Yoshihiro Matsuno, Michiyuki Maeda, Hiroo Hasegawa, Da-Wei Huang, Michael N. Petrus, Thomas A. Waldmann, Yuquan Lin, Takashi Yokota, Hideki Goto, Kanako C. Hatanaka, Louis M. Staudt
Publikováno v:
Blood. 139:1541-1556
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy with a poor prognosis with current therapy. Here we report genome-wide CRISPR-Cas9 screening of ATLL models, which identified CDK6, CCND2, BATF3, JUNB, STAT3, and IL10RB as gene