Zobrazeno 1 - 10
of 3 417
pro vyhledávání: ''
Autor:
Loredana Ruggeri, Elena Urbani, Davide Chiasserini, Federica Susta, Pier Luigi Orvietani, Emanuela Burchielli, Sara Ciardelli, Rosaria Sola, Stefano Bruscoli, Antonella Cardinale, Antonio Pierini, Sander R. Piersma, Stefano Pasquino, Franco Locatelli, Dunia Ramarli, Enrico Velardi, Luciano Binaglia, Connie R. Jimenez, Georg A. Holländer, Andrea Velardi
Publikováno v:
Blood, 140(22), 2323-2334. American Society of Hematology
Ruggeri, L, Urbani, E, Chiasserini, D, Susta, F, Orvietani, P L, Burchielli, E, Ciardelli, S, Sola, R, Bruscoli, S, Cardinale, A, Pierini, A, Piersma, S R, Pasquino, S, Locatelli, F, Ramarli, D, Velardi, E, Binaglia, L, Jimenez, C R, Holländer, G A & Velardi, A 2022, ' Donor natural killer cells trigger production of β-2-microglobulin to enhance post–bone marrow transplant immunity ', Blood, vol. 140, no. 22, pp. 2323-2334 . https://doi.org/10.1182/blood.2021015297
Ruggeri, L, Urbani, E, Chiasserini, D, Susta, F, Orvietani, P L, Burchielli, E, Ciardelli, S, Sola, R, Bruscoli, S, Cardinale, A, Pierini, A, Piersma, S R, Pasquino, S, Locatelli, F, Ramarli, D, Velardi, E, Binaglia, L, Jimenez, C R, Holländer, G A & Velardi, A 2022, ' Donor natural killer cells trigger production of β-2-microglobulin to enhance post–bone marrow transplant immunity ', Blood, vol. 140, no. 22, pp. 2323-2334 . https://doi.org/10.1182/blood.2021015297
Allogeneic hematopoietic transplantation is a powerful treatment for hematologic malignancies. Posttransplant immune incompetence exposes patients to disease relapse and infections. We previously demonstrated that donor alloreactive natural killer (N
Autor:
Jianqiong Zhu, Hongzhen Li, Wulin Aerbajinai, Chutima Kumkhaek, Mehdi Pirooznia, Ankit Saxena, Pradeep Dagur, Kyung Chin, Griffin P. Rodgers
Publikováno v:
Blood. 140:2276-2289
Sickle cell disease (SCD) and β-thalassemia are among the most common genetic disorders worldwide, affecting global health and mortality. Hemoglobin A2 (HbA2, α2δ2) is expressed at a low level in adult blood due to the lack of the Kruppel-like fac
Autor:
Jonas S. Jutzi, Anna E. Marneth, Michele Ciboddo, Angel Guerra-Moreno, María José Jiménez-Santos, Anastasia Kosmidou, James W. Dressman, Hongyan Liang, Rebecca Hamel, Patricia Lozano, Elisa Rumi, John G. Doench, Jason Gotlib, Anandi Krishnan, Shannon Elf, Fátima Al-Shahrour, Ann Mullally
Publikováno v:
Blood
Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by which CALR mutations cause MPNs has been elucidated, there currently are no clonally selective therapie
Autor:
Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue
Publikováno v:
Blood, 140(8), 875-888. American Society of Hematology
Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 drives inv(3)/t(3;3) myeloid leukemias via structural rearrangement of an enhancer that upregulates tran
Autor:
Martin G. Klatt, Tao Dao, Zhiyuan Yang, Jianying Liu, Sung Soo Mun, Megan M. Dacek, Hanzhi Luo, Thomas J. Gardner, Christopher Bourne, Leila Peraro, Zita E. H. Aretz, Tanya Korontsvit, Michael Lau, Michael G. Kharas, Cheng Liu, David A. Scheinberg
Publikováno v:
Blood. 140:861-874
Target identification for chimeric antigen receptor (CAR) T-cell therapies remains challenging due to the limited repertoire of tumor-specific surface proteins. Intracellular proteins presented in the context of cell surface HLA provide a wide pool o
Autor:
Haneen Shalabi, Haiying Qin, Angela Su, Bonnie Yates, Pamela L. Wolters, Seth M. Steinberg, John A. Ligon, Sara Silbert, Kniya DéDé, Mehdi Benzaoui, Sophia Goldberg, Sooraj Achar, Dina Schneider, Shilpa A. Shahani, Lauren Little, Toni Foley, John C. Molina, Sandhya Panch, Crystal L. Mackall, Daniel W. Lee, Christopher D. Chien, Marie Pouzolles, Mark Ahlman, Constance M. Yuan, Hao-Wei Wang, Yanyu Wang, Jon Inglefield, Mary Anne Toledo-Tamula, Staci Martin, Steven L. Highfill, Gregoire Altan-Bonnet, David Stroncek, Terry J. Fry, Naomi Taylor, Nirali N. Shah
Publikováno v:
Blood. 140:451-463
Remission durability following single-antigen targeted chimeric antigen receptor (CAR) T-cells is limited by antigen modulation, which may be overcome with combinatorial targeting. Building upon our experiences targeting CD19 and CD22 in B-cell acute
Autor:
Qiuyue Ma, Roland Immler, Monika Pruenster, Markus Sellmayr, Chenyu Li, Albrecht von Brunn, Brigitte von Brunn, Rosina Ehmann, Roman Wölfel, Matteo Napoli, Qiubo Li, Paola Romagnani, Ralph Thomas Böttcher, Markus Sperandio, Hans-Joachim Anders, Stefanie Steiger
Publikováno v:
Blood. 139:3402-3417
Neutrophils are key players during host defense and sterile inflammation. Neutrophil dysfunction is a characteristic feature of the acquired immunodeficiency during kidney disease. We speculated that the impaired renal clearance of the intrinsic puri
Autor:
Lidia M. Fernández-Sevilla, Jaris Valencia, Paula Ortiz-Sánchez, Alberto Fraile-Ramos, Pilar Zuluaga, Eva Jiménez, Rosa Sacedón, María V. Martínez-Sánchez, Janez Jazbec, Marusa Debeljak, Birthe Fedders, Martin Stanulla, Denis Schewe, Gunnar Cario, Alfredo Minguela, Manuel Ramírez, Alberto Varas, Ángeles Vicente
Publikováno v:
Blood. 139:3303-3313
Pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) outcome has improved in the last decades, but leukemic relapses are still one of the main problems of this disease. Bone morphogenetic protein 4 (BMP4) was investigated as a new candid
Autor:
Anudishi Tyagi, Stanley Ly, Fouad El-Dana, Bin Yuan, Appalaraju Jaggupilli, Sabrina Grimm, Marina Konopleva, Hans-Jörg Bühring, V. Lokesh Battula
Publikováno v:
Blood. 139:2782-2796
We observed that the immune checkpoint protein B7-H3 is overexpressed in acute myeloid leukemia (AML) patients with poor treatment outcomes. Inhibition of B7-H3 expression or blocking of its activity using a novel monoclonal antibody (T-1A5) in AML c
Autor:
Suelen Martins Perobelli, Chi L. Nguyen, Anastasia I. Kousa, Jonathan U. Peled, Joseph C. Sun, Justin R. Cross, Eli Zamir, Robert R. Jenq, Sebastien Monette, Melody Smith, Melissa D. Docampo, Ann E. Slingerland, Christoph K. Stein-Thoeringer, Clair D. Geary, Itamar Greenfield, Marina Burgos da Silva, Sophia R. Lieberman, Nicole Lee, Yusuke Shono, Gabe K Armijo, Emmanuel A Dwomoh, Kate A Markey, Marcel R M Rm van den Brink, Amina Lazrak, Katherine B Nichols, Santosha Vardhana
Publikováno v:
Blood
The intestinal microbiota is essential for the fermentation of dietary fiber into short-chain fatty acids (SCFA) such as butyrate, acetate, and propionate. SCFAs can bind to the G-protein-coupled receptors GPR43 and GPR109A (HCAR2), with varying affi