Zobrazeno 71 - 80
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Autor:
Patrick Schuhmachers, Antonino Bongiovanni, Hans J. Stauss, Kyra D. Zens, Angelika Holler, Yun Deng, Hana Zdimerova, Riccarda Capaul, Andrea Zbinden, Laure-Anne Ligeon, Wolfgang Hammerschmidt, Christian Münz, Anne Müller, Bithi Chatterjee
Publikováno v:
Blood
Blood 137, 3225-3236 (2021)
Blood 137, 3225-3236 (2021)
Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and a
Autor:
Yingchun Wang, Weilin Zhang, Ting Li, Lin Yang, Li Wei, Teng Liu, Aihua Wei, Xiahe Huang, Yuanying Chen, Yefeng Yuan, Quan Chen
Publikováno v:
Blood. 137:1804-1817
Lysosome-related organelles (LROs) are a category of secretory organelles enriched with ions such as calcium, which are maintained by ion transporters or channels. Homeostasis of these ions is important for LRO biogenesis and secretion. Hermansky-Pud
Autor:
Christophe Marcireau, Jing Fu, Divaya Bhutani, Jun Yang, Shirong Li, Suzanne Lentzsch, Markus Y. Mapara, Huihui Ma
Publikováno v:
Blood
In multiple myeloma (MM), frequent mutations of NRAS, KRAS, or BRAF are found in up to 50% of newly diagnosed patients. The majority of the NRAS, KRAS, and BRAF mutations occur in hotspots causing constitutive activation of the corresponding proteins
Autor:
Yubin Ge, Hong Liu, Rick Li, German Novakovskiy, Jun Yan, Depei Wu, Florian Kuchenbauer, Min Chen, Katharina Rothe, Zaihui Zhang, Xiuyan Zhang, Sung-Eun Nam, Yun Zhao, Irina A Maksakova, Xiaojia Niu, Xiaoyan Jiang, Yehyeon Ahn, Arefeh Rouhi, Shenshen Lai, Wyeth W. Wasserman, Calvin K. Yip, Sarah Grasedieck, Hong Zhang
Publikováno v:
Blood. 137:3641-3655
The abundance of genetic abnormalities and phenotypic heterogeneities in acute myeloid leukemia (AML) poses significant challenges to the development of improved treatments. Here, we demonstrated that a key growth arrest-specific gene 6/AXL axis is h
Autor:
Nirav Dhanesha, Madankumar Ghatge, Manasa K. Nayak, Steven R. Lentz, Gagan D. Flora, Matthew J. Potthoff, Kathleen R. Markan, Anil K. Chauhan, Manish Jain
Publikováno v:
Blood
Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic repr
Autor:
Dagmar Meyer zu Heringdorf, Corina Ratiu, Amro Elgheznawy, Voahanginirina Randriamboavonjy, Anastasia Kyselova, Ingrid Fleming, Mauro Siragusa, Alexander W. Mann, Beate Fisslthaler, Fredy Delgado Lagos
Publikováno v:
Blood. 137:1641-1651
Secreted modular calcium-binding protein 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression is regulated by microRNA-223 (miR-223). Given that platelets are rich in miR-223, this study investigated the expression of SMO
Autor:
Reiji Fukano, R. Coleman Lindsley, Elena Varotto, Burgess B. Freeman, Kirsten Dickerson, Harini Jogiraju, Debbie Payne-Turner, Anang A. Shelat, Laura J. Janke, Aman Seth, Chunxu Qu, Jiyang Yu, James A. Kennedy, Emily S. Hollis, Georgia E. Haggard, Sarah M. Morris, Yingzhe Wang, Benjamin L. Ebert, Charles G. Mullighan, Ilaria Iacobucci, Rena Zheng, Jake D. Friske, Xu Yang, Nina Ghosn, Adam S. Sperling
Publikováno v:
Blood. 137:1628-1640
Acute erythroid leukemia (AEL) is characterized by a distinct morphology, mutational spectrum, lack of preclinical models, and poor prognosis. Here, using multiplexed genome editing of mouse hematopoietic stem and progenitor cells and transplant assa
Autor:
Chengli Guo, Jing Wang, Kexin Gao, Yashu Li, Rong Yin, Mengdie Feng, Zhuying Gao, Jin Hu, Tiantian Zhang, Guoqiang Han, Fuling Zhou, Jiwei Chang, Jihua Chai, Xueqin Xie, Yicun Li, Weidong Liu, Manman Cui, Peipei Wang, Ying Cheng, Haojian Zhang, Qifan Wang, Tong Zhang, Shaoguang Li, Lingbo Liu, Jianjun Chen
Publikováno v:
Blood. 138:71-85
RNA-binding proteins (RBPs) are critical regulators of transcription and translation that are often dysregulated in cancer. Although RBPs are increasingly recognized as being important for normal hematopoiesis and for hematologic malignancies as onco
Autor:
Michael F. Moran, Biyin Cao, Xinliang Mao, Jinhao Chen, Jiefei Tong, Zubin Zhang, Xiaowen Tang, Depei Wu, A. Keith Stewart, Yujia Xu, Min Xu, Xue-han Chen
Publikováno v:
Blood. 137:1478-1490
The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM), but how to achieve it is still elusive. In the present study, we found the Otub1/c-Maf axis could be a potential target. Otub1, an OT