Zobrazeno 241 - 250
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Autor:
Zaki Al-Yafeai, Robert P. Hebbel, Rafal Pawlinski, Junaid Ansari, Shantel Vital, Elena Y. Senchenkova, Gaganpreet Kaur, Erica M. Sparkenbaugh, Felicity N. E. Gavins, A. Wayne Orr, D. Neil Granger, Paul Kubes
Publikováno v:
Blood
Neutrophils play a crucial role in the intertwined processes of thrombosis and inflammation. An altered neutrophil phenotype may contribute to inadequate resolution, which is known to be a major pathophysiological contributor of thromboinflammatory c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1162ff552d74400b8019a8b38d604f
https://bura.brunel.ac.uk/handle/2438/22185
https://bura.brunel.ac.uk/handle/2438/22185
Autor:
Julie Agopian, Quentin Da Costa, John M. Asara, Cristina Teodosio, Julien Maurizio, Paulo De Sepulveda, Min Yuan, Fabienne Brenet, Rabie Chelbi, Patrice Dubreuil, Olivier Hermine, Quang Vo Nguyen, Giulia Scorrano, Alberto Orfao, Paraskevi Kousteridou, Armelle Goubard, Rémy Castellano
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Blood
Blood, 2021, 138 (17), pp.1590-1602. ⟨10.1182/blood.2020008948⟩
instname
Blood
Blood, 2021, 138 (17), pp.1590-1602. ⟨10.1182/blood.2020008948⟩
Systemic mastocytosis (SM) is a KIT-driven hematopoietic neoplasm characterized by the excessive accumulation of neoplastic mast cells (MCs) in various organs and, mainly, the bone marrow (BM). Multiple genetic and epigenetic mechanisms contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f56b4f4ae24d4c10d30bf94cab1a17e
http://hdl.handle.net/10261/261506
http://hdl.handle.net/10261/261506
Autor:
Jessica Minnier, Owen J. T. McCarty, Emek Demir, Phillip A. Wilmarth, Samuel Tassi Yunga, Özgün Babur, Jiaqing Pang, Jennifer M. Cunliffe, Anna Liisa I. Sepp, Ashok P. Reddy, Jevgenia Zilberman-Rudenko, Iván Parra-Izquierdo, John Klimek, Alexander R. Melrose, Joseph E. Aslan, Larry L. David, Tony J. Zheng
Publikováno v:
Blood
Platelets engage cues of pending vascular injury through coordinated adhesion, secretion, and aggregation responses. These rapid, progressive changes in platelet form and function are orchestrated downstream of specific receptors on the platelet surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294ffe926402540c2cd6f90d02b819c9
https://europepmc.org/articles/PMC7702475/
https://europepmc.org/articles/PMC7702475/
Autor:
Gavin R. Lloyd, Ugo Scarpa, Andrew D. Southam, Barbara Martins da Costa, Orli Yogev, Vanessa Tubb, Carmela De Santo, Silvia Panetti, Livingstone Fultang, Steven P. Lee, Andris Jankevics, Sarah Booth, Louis Chesler, Warwick B. Dunn, Victoria Stavrou, Francis Mussai
Publikováno v:
Blood
Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine microenvironment also impairs chimeric antigen receptor T cells (CAR-T) cell proliferation, limiting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a99a6e5d4ec34ec171f318b81069e40
https://europepmc.org/articles/PMC7565134/
https://europepmc.org/articles/PMC7565134/
Autor:
Pinyi Lu, Longgui Chen, Barbara A. Miller, Zhongming Zhao, Charyguly Annageldiyev, Melat T. Gebru, Christopher M. Dower, Jennifer M. Atkinson, Arati Sharma, Megan M. Young, Zhenyuan Tang, Hong Gang Wang, Lijun Zhang, David F. Claxton, Yuka Imamura Kawasawa, Zhenqiu Liu
Publikováno v:
Blood
FLT3 is a frequently mutated gene that is highly associated with a poor prognosis in acute myeloid leukemia (AML). Despite initially responding to FLT3 inhibitors, most patients eventually relapse with drug resistance. The mechanism by which resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a15350f4c228b28961190773dd4afe
https://europepmc.org/articles/PMC7453151/
https://europepmc.org/articles/PMC7453151/
Autor:
Thomas B. Bartnikas
Publikováno v:
Blood
Matriptase-2 (MT2), encoded by TMPRSS6, is a membrane-anchored serine protease that plays a key role in suppressing hepatic hepcidin expression. MT2 is synthesized as a zymogen and undergoes autocleavage for activation. Previous studies suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412d3f8ee1e5e1d6aa3480a23e0354be
https://europepmc.org/articles/PMC7441165/
https://europepmc.org/articles/PMC7441165/
Autor:
Margaret A. Goodell, Grant A. Challen
Publikováno v:
Blood
The discovery of clonal hematopoiesis (CH) in older individuals has changed the way hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem cells over time. While most mutations have no impact, some result in subtle fu
Autor:
Frederick D. Tsai, R. Coleman Lindsley
Publikováno v:
Blood
Inherited bone marrow failure syndromes (IBMFSs) are characterized by ineffective hematopoiesis and increased risk for developing myeloid malignancy. The pathophysiologies of different IBMFSs are variable and can relate to defects in diverse biologic
Autor:
Daniel C. Link, Julia T. Warren
Publikováno v:
Blood
Clonal hematopoiesis is common in older persons and is associated with an increased risk of hematologic cancer. Here, we review studies establishing an association between clonal hematopoiesis and hematopoietic malignancy, discuss features of clonal
Autor:
Nicholas T. Woods, Catalina Amador, Shannon M. Buckley, Samantha A. Swenson, Heather Vahle, Michael R. Green, Henry C.-H. Law, Tyler J. Gilbreath, Jared H. Graham, R. Willow Hynes-Smith
Publikováno v:
Blood
Coordination of a number of molecular mechanisms including transcription, alternative splicing, and class switch recombination are required to facilitate development, activation, and survival of B cells. Disruption of these pathways can result in mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf09b594fd0e5984087ef0c07628dfe
https://europepmc.org/articles/PMC7365918/
https://europepmc.org/articles/PMC7365918/