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of 375
pro vyhledávání: ''
Autor:
Alain Fournier, Marielle Chiron, Nadège Carrié, Sukhvinder Sidhu, Marine Cuisinier, Sahar Kassem, Dmitri Wiederschain, Hélène Bonnevaux, Jean-Luc Teillaud, Ludovic Martinet, Helgi van de Velde, Jill Corre, Isabelle Arnould, Béré K. Diallo, Nizar El-Murr, Céline Nicolazzi, Angela Virone-Oddos, Hervé Avet-Loiseau, Alexandre Tang
Publikováno v:
Blood. 139:1160-1176
Anti-CD38 monoclonal antibodies (mAbs) represent a breakthrough in the treatment of multiple myeloma (MM), yet some patients fail to respond or progress quickly with this therapy, highlighting the need for novel approaches. In this study we compared
Autor:
Elisa Ten Hacken, Catherine J. Wu
Publikováno v:
Blood
Rapid advances in large-scale next-generation sequencing studies of human samples have progressively defined the highly heterogeneous genetic landscape of chronic lymphocytic leukemia (CLL). At the same time, the numerous challenges posed by the diff
Autor:
Nagham Alouche, Niclas Setterblad, Amélie Bonaud, Karl Balabanian, Etienne Crickx, Valeria Bisio, Mélanie Khamyath, David H. McDermott, Matthieu Mahévas, Nicolas Dulphy, Philip M. Murphy, Marion Espéli, Vincent Rondeau, Rim Hussein-Agha, Julie Nguyen
Publikováno v:
Blood
The extrafollicular immune response is essential to generate a rapid but transient wave of protective antibodies during infection. Despite its importance, the molecular mechanisms controlling this first response are poorly understood. Here, we demons
Autor:
Andrew Volk
Publikováno v:
Blood
YTHDC1 has distinct functions as a nuclear N(6)-methyladenosine (m(6)A) reader in regulating RNA metabolism. Here we show that YTHDC1 is overexpressed in acute myeloid leukemia (AML) and that it is required for the proliferation and survival of human
Autor:
Patrick Schuhmachers, Antonino Bongiovanni, Hans J. Stauss, Kyra D. Zens, Angelika Holler, Yun Deng, Hana Zdimerova, Riccarda Capaul, Andrea Zbinden, Laure-Anne Ligeon, Wolfgang Hammerschmidt, Christian Münz, Anne Müller, Bithi Chatterjee
Publikováno v:
Blood
Blood 137, 3225-3236 (2021)
Blood 137, 3225-3236 (2021)
Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and a
Autor:
Ren Lai, June Li, Runjia Xu, Pingguo Chen, Zilei Duan, Heyu Ni, James Mwangi, Daniel Thomas Mackeigan, Fatima Zohra Dahmani, Gan Wang, Wenjing Ma, Ming Liu, Chuanbin Shen, Qiumin Lu, Zhiye Zhang
Publikováno v:
Blood. 136:974-988
Several adaptor molecules bind to cytoplasmic tails of β-integrins and facilitate bidirectional signaling, which is critical in thrombosis and hemostasis. Interfering with integrin-adaptor interactions spatially or temporally to inhibit thrombosis w
Autor:
Juan José Lozano, Linda Ariza-McNaughton, Jonathan M. Irish, Syed A Mian, Benedetta Costantini, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Thanos P. Mourikis, Shok Ping Lim, Pilar Perez Abellan, Giovanni A M Povoleri, Ghulam J. Mufti, Susanne Heck, Giovanna Lombardi, Ander Abarrategi, Shreyans Gandhi, Marc Martinez Llordella, Rita Antunes Dos Reis
Publikováno v:
Blood. 136:885-897
Idiopathic aplastic anemia (AA) has 2 key characteristics: an autoimmune response against hematopoietic stem/progenitor cells and regulatory T-cells (Tregs) deficiency. We have previously demonstrated reduction in a specific subpopulation of Treg in
Autor:
Siyang Hao, Baiye Ruan, Jie Xiang, K. Sandeep Prabhu, Yuanting Chen, Fenghua Qian, Robert F. Paulson, Bastihalli T. Diwakar
Publikováno v:
Blood
Anemic stress induces stress erythropoiesis, which rapidly generates new erythrocytes to restore tissue oxygenation. Stress erythropoiesis is best understood in mice where it is extramedullary and occurs primarily in the spleen. However, both human a
Autor:
Stephanie C. Eisenbarth, James E Forsmo, Jingchun Liu, Dong Liu, V. Escamilla-Rivera, James C. Zimring, Sean R. Stowell, David R Gibb, Manjula Santhanakrishnan, Chance John Luckey, Ellen F. Foxman, Jeanne E. Hendrickson, Krystalyn E. Hudson
Publikováno v:
Blood. 135:1983-1993
Polyclonal anti-D (Rh immune globulin [RhIg]) therapy has mitigated hemolytic disease of the newborn over the past half century, although breakthrough anti-D alloimmunization still occurs in some treated females. We hypothesized that antiviral respon
Autor:
Nigel S. Key, Erica M. Sparkenbaugh, John D. Belcher, Tomasz Brzoska, Rafal Pawlinski, Shaobin Wang, Gregory M. Vercellotti, Julia Nguyen, Chunsheng Chen, Prithu Sundd
Publikováno v:
Blood
Vaso-occlusive crisis (VOC) is the primary cause of morbidity and hospitalization in sickle cell disease (SCD); however, only 4 therapies (hydroxyurea, l-glutamine, crizanlizumab, and voxeletor) are currently approved in SCD. These agents limit the d