Zobrazeno 1 - 10
of 257
pro vyhledávání: ''
Autor:
Jan Stetka, Nouraiz Ahmed, Christian Beisel, Damien Luque Paz, Nils Hansen, Julian Hilfiker, Dominik Wolf, Steffen Koschmieder, Florian Geier, Hui Hao-Shen, Milena Kalmer, Stefan Dirnhofer, Tim H. Brümmendorf, Tata Nageswara Rao, Lucia Kubovcakova, Timm Schroeder, Max Endele, Margareta Rybarikova, Radek C. Skoda
Publikováno v:
Blood
Blood, 137 (16)
Blood, 137 (16)
We studied a subset of hematopoietic stem cells (HSCs) that are defined by elevated expression of CD41 (CD41hi) and showed bias for differentiation toward megakaryocytes (Mks). Mouse models of myeloproliferative neoplasms (MPNs) expressing JAK2-V617F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622010d9de59c7bbdfe5a74c85004689
https://europepmc.org/articles/PMC8103999/
https://europepmc.org/articles/PMC8103999/
Autor:
Ling Li, Maged Henary, Yabing Chen, Chiao-Wang Sun, Kevin M. Pawlik, Szu-Mam Liu, Y. George Zheng, Tim M. Townes, Hao Hu, Christopher A. Klug, Hairui Su, Xiaosi Han, Xinyang Zhao, Xin He
Publikováno v:
Blood Advances. 2:2829-2836
Dynamic regulation of histone modification enzymes such as PRMT1 (protein arginine methyltransferase 1) determines the ordered epigenetic transitions in hematopoiesis. Sorting cells according to the expression levels of histone modification enzymes m
Autor:
Coline Gaillard, Sangeetha Surianarayanan, Trevor Bentley, Matthew R. Warr, Briana Fitch, Huimin Geng, Emmanuelle Passegué, Hugues de Thé, Scott C. Kogan
Publikováno v:
Blood advances, vol 2, iss 19
The classical paradigm suggests that PML/RARA fusion protein is the main driver of pathogenesis in APL. It is believed that the fusion oncogenic protein mediates this effect by potentially repressing key myeloid maturation genes involved in different
Autor:
Rodney M. Camire, Deborah L. French, Danuta Jarocha, Mortimer Poncz, Hayley A. Hanby, Michael S. Marks, Vincent Hayes, Xiuli Sim, Paul Gadue
Publikováno v:
Blood. 130:192-204
Stem cell-derived platelets have the potential to replace donor platelets for transfusion. Defining the platelet-producing megakaryocytes (MKs) within the heterogeneous MK culture may help to optimize the in vitro generation of platelets. Using 2 hum
Autor:
Vivek Rai, Rashmi Ray
Publikováno v:
Blood. 129:1177-1183
Monocytes and macrophages represent critical arms of the innate immune system and are considered regulators and effectors of inflammation and the innate immune response. Monocytes can mobilize from bone marrow, traffic to their required destination,
Publikováno v:
Blood. 129:209-225
Downstream regulatory element antagonist modulator (DREAM), a transcriptional repressor, is known to modulate pain responses. However, it is unknown whether DREAM is expressed in anucleate platelets and plays a role in thrombogenesis. By using intrav
Publikováno v:
Blood. 129:238-245
Replacement therapy with factor VIII (FVIII) is used in patients with hemophilia A for treatment of bleeding episodes or for prophylaxis. A common and serious problem with this therapy is the patient's immune response to FVIII, because of a lack of t
Autor:
Jingchun Liu, Stephanie C. Eisenbarth, Alexa J. Siddon, Donald R. Branch, Jeanne E. Hendrickson, David R Gibb, Christopher A. Tormey, Prabitha Natarajan, Manjula Santhanakrishnan, Sean R. Stowell
Publikováno v:
Blood. 128:3159-3168
Red blood cell (RBC) alloimmunization is a serious complication of transfusion or pregnancy. Despite the widespread use of Rh immune globulin to prevent pregnancy associated anti-D alloimmunization, its mechanism of action remains elusive. We have pr
Autor:
Jessica Sullivan, Oliver Hofmann, Scott B. Ficarro, John N. Hutchinson, Jarrod A. Marto, Roland Csépányi-Kömi, Erzsébet Ligeti, Phi T. Nguyen, Éva Wisniewski, Amy J. Wagers, Leo D. Wang
Publikováno v:
Blood. 128:1465-1474
Protein phosphorylation is a central mechanism of signal transduction that both positively and negatively regulates protein function. Large-scale studies of the dynamic phosphorylation states of cell signaling systems have been applied extensively in
Autor:
Jianzhu Chen, Nalini Srinivasan, Junyun Lai, Joanna Ai Ling Choo, Wei Jian Tan, Fatimah Bte Mustafa, Youjia Zhong, Paul A. MacAry, Chien Tei Too, Angeline Pei Chiew Lim, Soh Ha Chan, Lan Hiong Wong, Nicholas R. J. Gascoigne, Brendon J. Hanson
Publikováno v:
Blood. 128:1396-1407
Epstein-Barr virus (EBV) is an oncovirus associated with several human malignancies including posttransplant lymphoproliferative disease in immunosuppressed patients. We show here that anti-EBV T-cell receptor-like monoclonal antibodies (TCR-like mAb