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pro vyhledávání: ''
Autor:
Hartmut Döhner, Daniela Weber, Julia Krzykalla, Walter Fiedler, Gerald Wulf, Helmut Salih, Michael Lübbert, Michael W. M. Kühn, Thomas Schroeder, Hans Salwender, Katharina Götze, Jörg Westermann, Lars Fransecky, Karin Mayer, Bernd Hertenstein, Mark Ringhoffer, Hans-Joachim Tischler, Sigrid Machherndl-Spandl, Anika Schrade, Peter Paschka, Verena I. Gaidzik, Frauke Theis, Felicitas Thol, Michael Heuser, Richard F. Schlenk, Lars Bullinger, Maral Saadati, Axel Benner, Richard Larson, Richard Stone, Konstanze Döhner, Arnold Ganser
Publikováno v:
Blood Advances. 6:5345-5355
We conducted a single-arm, phase 2 trial (German-Austrian Acute Myeloid Leukemia Study Group [AMLSG] 16-10) to evaluate midostaurin with intensive chemotherapy followed by allogeneic hematopoietic-cell transplantation (HCT) and a 1-year midosta urin
Autor:
Tao Wang, Helen E. Heslop, Stephen Gottschalk, Bambi Grilley, Rammurti T. Kamble, Carlos A. Ramos, Ann M. Leen, Meng-Fen Wu, Malcolm K. Brenner, Robert A. Krance, Catherine Robertson, Manik Kuvalekar, Jasleen K. Randhawa, Spyridoula Vasileiou, Adrian P. Gee, Suhasini Lulla, Juan F. Vera, Betty Chung, Ayumi Watanabe, Premal Lulla, Ifigeneia Tzannou, Swati Naik, LaQuisa Hill, George Carrum
Publikováno v:
Blood
Relapse after allogeneic hematopoietic stem cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Infusion of unselected donor lymphocytes (DLIs) enhances the graft-v
Autor:
Mercedeh Tajdar, Helena Devos, Dominik Selleslag, Friedel Nollet, Pieter Van Vlierberghe, Louis Nevejan, Matthijs Vynck, Tom Lodewyck
Publikováno v:
Blood Adv
Clonal hematopoiesis (CH) is associated with age and an increased risk of myeloid malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting where hematopoietic stem cells (HSCs) of the same individual are exposed to di
Autor:
Aparna Gopal, Megan Fuller, Yu Deng, Mark Boldin, Jennifer M Grants, Aly Karsan, Joanna Wegrzyn, David J.H.F. Knapp, Connie J. Eaves, T. Roderick Docking, Tony Hui, Jenny Li, Marion Shadbolt, Kieran O'Neill, Jeremy Parker, Martin Hirst
Publikováno v:
Blood
Aging is associated with significant changes in the hematopoietic system, including increased inflammation, impaired hematopoietic stem cell (HSC) function, and increased incidence of myeloid malignancy. Inflammation of aging (“inflammaging”) has
Autor:
Aline Tanguy-Schmidt, Sébastien Maury, Paola Ballerini, Nicolas Sirvent, Judith Landman-Parker, Patrice Chevallier, E. Dore, Cédric Duclos, Ibrahima Ba, Hélène Cavé, Jean Soulier, Massimiliano Bonifacio, Nicolas Duployez, Chantal Himberlin, André Baruchel, Hervé Dombret, Thorsten Braun, Ilaria Tanasi, Emmanuelle Clappier, Jerome Tamburini, Nicolas Boissel, Wendy Cuccuini, Philippe Rousselot
Publikováno v:
Blood
Blood, American Society of Hematology, 2019, 134 (16), pp.1351-1355. ⟨10.1182/blood.2019001244⟩
Blood, American Society of Hematology, 2019, 134 (16), pp.1351-1355. ⟨10.1182/blood.2019001244⟩
Tanasi et al present a prospective strategy for identifying patients with Philadelphia-like acute lymphoblastic leukemia, demonstrating the efficacy of early introduction of tyrosine kinase inhibitors in improving outcomes.
Autor:
Mario Cazzola, Alessandro M. Vannucchi, Chiara Paoli, Rossella Manfredini, Paola Guglielmelli, Elisa Rumi, Francesco Mannelli, Annalisa Pacilli, Sara Fiaccabrino, Giada Rotunno, Giada Brogi, Giovanni Barosi, Benedetta Sordi, Francesca Gesullo, Carmela Mannarelli, Ilaria M. Marone
Publikováno v:
Blood. 133:2802-2808
TO THE EDITOR: The discovery of prognostically informative mutations in patients with primary myelofibrosis (PMF)[1][1] prompted the development of mutation-enhanced risk scores.[2][2][⇓][3][⇓][4][⇓][5]-[6][6] Among these mutations, those in AS
Autor:
Mathijs A. Sanders, Sandra Kaiser, Wei Wang, Sarolta Bojtine Kovacs, Lars Bullinger, Bruno Cassinat, Annelieke Zeilemaker, Christoph Koellerer, Peter J. M. Valk, Jonas S. Jutzi, Titiksha Basu, Adil Al Hinai, Jenny Ostendorp, Brigitte Schlegelberger, Heike L. Pahl, Emmanuel Raffoux, Doris Steinemann, Maximilian Pellmann, Konrad Aumann
Publikováno v:
Blood, 133(16), 1766-1777. American Society of Hematology
In acute myeloid leukemia (AML), acquired genetic aberrations carry prognostic implications and guide therapeutic decisions. Clinical algorithms have been improved by the incorporation of novel aberrations. Here, we report the presence and functional
Autor:
Ravi Sharaf, Blanche P. Alter, Philip S. Rosenberg, Kenan Onel, Adrianna Vlachos, Eva Atsidaftos, Jeffrey M. Lipton, Jessica Kang
Publikováno v:
Blood. 132:2205-2208
TO THE EDITOR: Inherited bone marrow failure syndromes (IBMFSs), characterized by bone marrow failure and developmental anomalies, are among a group of rare cancer predisposition syndromes. As illustrated by Fanconi anemia (FA),[1][1] the unique biol
Autor:
Mark J. Smyth, Rachel Koldej, Sara Mastaglio, Piers Blombery, Jane Ripley, Eric Wong, David Ritchie, Travis Perera
Publikováno v:
Blood Advances. 2:335-346
Natural killer (NKs) cells provide rapid responses to viral-infected and malignant cells, including acute myeloid leukemia (AML) blasts. The balance among inhibitory and activating signals, delivered by multiple interactions between ligands on target
Autor:
Niki Stavroyianni, Helga D. Munch-Petersen, Kenichi Yoshida, Markus Schneider, Andreas Rosenwald, German Ott, Lucile Couronné, Michael Hummel, Marita Ziepert, Daniel Noerenberg, Emma Young, Richard Rosenquist, Seishi Ogawa, Thorsten Zenz, Jonathan C. Strefford, Larry Mansouri, Rose-Marie Amini, Hans G. Drexler, Viktor Ljungström, Martin-Leo Hansmann, Mareike Frick, Dido Lenze, Martin Erlanson, Ralf Küppers, Alfredo Rivas-Delgado, Armando López-Guillermo, Elisabeth Ralfkiaer, Christopher Maximilian Arends, Magnus Hultdin, Tatjana Pandzic, Bernd Dörken, Claudia D. Baldus, Maria K. Angelopoulou, Theodora Papadaki, Kirsten Grønbæk, Kostas Stamatopoulos, Anna Tasidou, Maysaa Abdulla, Nils Waldhueter, Frederik Damm, Theodoros P. Vassilakopoulos, Elias Campo, Damien Roos-Weil, Jude Fitzgibbon, Elena Mylonas, Blanca Gonzalez, Penelope Korkolopoulou, George Kanellis, Aron Skaftason, Gunilla Enblad, Olivier A. Bernard, Fazila Asmar, Jessica Okosun, Clemens A. Schmitt, Christian Bastard
Publikováno v:
Blood. 128:2666-2670
We recently reported a truncating deletion in the NFKBIE gene, which encodes IκBε, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Because preliminary data indicate enrichment of NFKBIE aberrati