Zobrazeno 61 - 70
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Autor:
Stefano Monti, Nancy L. Harris, Christine Ladd, Françoise Berger, Thomas M. Habermann, Todd R. Golub, Wen Jing, Margaret A. Shipp, Jon C. Aster, Jeffery L. Kutok, Gilles Salles, Riccardo Dalla-Favera, Paola Dal Cin, Ricardo C.T. Aguiar, Paul J. Kurtin, Laurence de Leval, Friedrich Feuerhake, Donna Neuberg, Geraldine S. Pinkus, Giorgio Cattoretti, Sigui Li, Kerry J. Savage
Publikováno v:
Blood. 102:3871-3879
Mediastinal large B-cell lymphoma (MLBCL) is a recently identified subtype of diffuse large B-cell lymphoma (DLBCL) that characteristically presents as localized tumors in young female patients. Although MLBCL has distinctive pathologic features, it
Autor:
Yutaka Kondo, Lan Lan Shen, Sherry Pierce, Toshiro Obata, Kohzoh Imai, Minoru Toyota, Hagop M. Kantarjian, Sophia Daniel, Jean Pierre J. Issa, Guillermo Garcia-Manero
Publikováno v:
Blood. 101:4131-4136
P57KIP2 is a cyclin-dependent kinase inhibitor silenced in a variety of human malignancies. DNA methylation of a region surrounding the transcription start site of p57KIP2 was found in acute lymphocytic leukemia (ALL)–derived cell lines. Methylatio
Autor:
Chris J.L.M. Meijer, Gert J. Ossenkoppele, Rosita L. ten Berge, D. F. Dukers, Wim Vos, Joost J. Oudejans
Publikováno v:
Blood. 100:36-42
In vitro studies suggest that resistance to the apoptosis-inducing effect of chemotherapy might explain poor responses to therapy in fatal instances of Hodgkin disease (HD). Execution of apoptosis depends on proper functioning of effector caspases, i
Autor:
Charles L. Sawyers, Feiyu Zhang, Stephen J. Forman, Ravi Bhatia, Melissa Holtz, Marilyn L. Slovak
Publikováno v:
Blood. 99:3792-3800
Imatinib mesylate (STI571) is a promising new treatment for chronic myelogenous leukemia (CML). The effect of imatinib mesylate on primitive malignant progenitors in CML has not been evaluated, and it is not clear whether suppression of progenitor gr
Autor:
Naoki Hosen, Takeshi Kubota, Toshihiro Soma, Tadamitsu Kishimoto, Manabu Kawakami, Akihiro Tsuboi, Yusuke Oji, Hiroya Tamaki, Hiroyasu Ogawa, Keiko Udaka, Olga A. Elisseeva, Fei Wu, Eui Ho Kim, Taisei Nomura, Kiyoyuki Ogata, Yoshihiro Oka, Haruo Sugiyama, Tamotsu Yamagami, Machiko Tsukaguchi, Masashi Nakagawa, Akira Hiraoka
Publikováno v:
Blood. 99:3272-3279
Wilms tumor gene WT1 is expressed at high levels in hematopoietic malignancies, such as leukemias and myelodysplastic syndromes (MDS), and in various kinds of solid tumors, including lung cancer, and it exerts an oncogenic function in these malignanc
Autor:
Beatrix Mueller, Joerg Willers, Mirjana Urosevic, Reinhard Dummer, Guenter Burg, Werner Kempf
Publikováno v:
Blood. 99:609-617
Primary cutaneous lymphomas (CLs) constitute a spectrum of diseases characterized by a clonal accumulation of lymphocytes in the skin. Most CLs display a Th2 cytokine profile, including expression of interleukin-10 (IL-10). Because the up-regulation
Autor:
Lorenz Trümper, Andrew J. Elia, Randy D. Gascoyne, Ursula Kapp, Bruce K. Patterson, Tak W. Mak, Brian F. Skinnider
Publikováno v:
Blood. 99:618-626
The unique clinicopathologic features of Hodgkin lymphoma (HL) are due to the multiple cytokines produced by its neoplastic cells, the Hodgkin and Reed-Sternberg (HRS) cells. Cytokine signaling is mediated through the signal transducer and activator
Autor:
Chris J.L.M. Meijer, Karien M. Hamer, Arie P. Otte, Folkert J. van Kemenade, Elly Fieret, Tjasso Blokzijl, David P. E. Satijn, Frank M. Raaphorst
Publikováno v:
Blood. 97:3896-3901
Polycomb-group (PcG) proteins, such as BMI-1 and EZH2, form multimeric gene-repressing complexes involved in axial patterning, hematopoiesis, and cell cycle regulation. In addition, BMI-1 is involved in experimental lymphomagenesis. Little is known a
Autor:
Pellegrino Musto, Luciana Teofili, Luigi Maria Larocca, Anna Laura Di Febo, Sergio Rutella, Nicola Di Renzo, Giuseppe Leone, Antonella Cingolani, Nicola Maggiano, Stefano Pileri, Maurizio Bendandi, Francesco Pierconti
Publikováno v:
Blood. 97:1063-1069
The receptor for hepatocyte growth factor (HGF) is a transmembrane tyrosine kinase that is encoded by the proto-oncogene c-met. Recently, c-MET was detected in Reed-Sternberg (RS) cells from Epstein-Barr virus–positive (EBV+) Hodgkin disease (HD).
Autor:
Narikazu Iijima, Hidehiko Saito, Mitsune Tanimoto, Koichi Miyamura, Toshihide Itou, Ryou Sobue
Publikováno v:
Blood. 90:4901-4909
Clinical studies of bone marrow transplantation (BMT) suggest that the immune system contributes to the eradication of acute myeloid leukemia (AML). A recent study also showed that the Fas (CD95/APO1) mediates apoptotic signal from cytotoxic T lympho