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Autor:
Mark J. Smyth, Rachel Koldej, Sara Mastaglio, Piers Blombery, Jane Ripley, Eric Wong, David Ritchie, Travis Perera
Publikováno v:
Blood Advances. 2:335-346
Natural killer (NKs) cells provide rapid responses to viral-infected and malignant cells, including acute myeloid leukemia (AML) blasts. The balance among inhibitory and activating signals, delivered by multiple interactions between ligands on target
Autor:
Niki Stavroyianni, Helga D. Munch-Petersen, Kenichi Yoshida, Markus Schneider, Andreas Rosenwald, German Ott, Lucile Couronné, Michael Hummel, Marita Ziepert, Daniel Noerenberg, Emma Young, Richard Rosenquist, Seishi Ogawa, Thorsten Zenz, Jonathan C. Strefford, Larry Mansouri, Rose-Marie Amini, Hans G. Drexler, Viktor Ljungström, Martin-Leo Hansmann, Mareike Frick, Dido Lenze, Martin Erlanson, Ralf Küppers, Alfredo Rivas-Delgado, Armando López-Guillermo, Elisabeth Ralfkiaer, Christopher Maximilian Arends, Magnus Hultdin, Tatjana Pandzic, Bernd Dörken, Claudia D. Baldus, Maria K. Angelopoulou, Theodora Papadaki, Kirsten Grønbæk, Kostas Stamatopoulos, Anna Tasidou, Maysaa Abdulla, Nils Waldhueter, Frederik Damm, Theodoros P. Vassilakopoulos, Elias Campo, Damien Roos-Weil, Jude Fitzgibbon, Elena Mylonas, Blanca Gonzalez, Penelope Korkolopoulou, George Kanellis, Aron Skaftason, Gunilla Enblad, Olivier A. Bernard, Fazila Asmar, Jessica Okosun, Clemens A. Schmitt, Christian Bastard
Publikováno v:
Blood. 128:2666-2670
We recently reported a truncating deletion in the NFKBIE gene, which encodes IκBε, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Because preliminary data indicate enrichment of NFKBIE aberrati
Autor:
Alfonso Quintás-Cardama, Aziz Nazha, Farhad Ravandi, Gautam Borthakur, Srdan Verstovsek, Hagop M. Kantarjian, Elias Jabbour, Jorge E. Cortes, Sherry Pierce, Marylou Cardenas-Turanzas, Carlos Guillermo Romo, Preetesh Jain, Susan O'Brien
Publikováno v:
Blood. 121:4867-4874
Early responses to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML)-chronic phase (CP) are associated with improved outcome. We analyzed the impact of such a response on outcomes among patients treated with 4 TKI modalities as fron
Autor:
Zhiyu Zhang, Kati Maharry, Zejuan Li, Colles Price, Xi Jiang, Peter J. M. Valk, Lars Bullinger, Michael D. Radmacher, Janet D. Rowley, Konstanze Döhner, Yves A. Lussier, Miao He, Michelle M. Le Beau, Clara D. Bloomfield, Hao Huang, Xinan Yang, Richard A. Larson, Jianjun Chen, Yuanyuan Li, Stephen Arnovitz, Ruud Delwel, Chunjiang He, Abdel G. Elkahloun, Yanming Zhang, Ping Chen, Mary Beth Neilly, Paul P. Liu, Guido Marcucci, Michael A. Caligiuri, Bob Löwenberg
Publikováno v:
Blood, 119(10), 2314-2324. American Society of Hematology
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also sign
Autor:
Yihua Qiu, Nianxiang Zhang, Neera Singh, Dennis K. Watson, Stefan Faderl, Alessandra Ferrajoli, Heather York, Amina A. Qutub, Steven M. Kornblau, Kevin R. Coombes
Publikováno v:
Blood. 118:5604-5612
Friend leukemia virus integration 1 (FLI1), an Ets transcription factor family member, is linked to acute myelogenous leukemia (AML) by chromosomal events at the FLI1 locus, but the biologic impact of FLI1 expression on AML is unknown. FLI1 protein e
Autor:
Yihua Qiu, Erich Koller, Duncan H. Mak, Bing Z. Carter, Deborah A. Thomas, Nianxiang Zhang, Farhad Ravandi, Steven M. Kornblau, Hagop M. Kantarjian, Michael Andreeff, Kevin R. Coombes
Publikováno v:
Blood. 117:780-787
Regulators of apoptosis in acute myeloid leukemia (AML) have been extensively studied and are considered excellent therapeutic targets. Apoptosis repressor with caspase recruitment domain (ARC), an antiapoptotic protein originally found to be involve
Autor:
Madlen Ulke, Torsten Haferlach, Susanne Schnittger, Claudia Haferlach, Tamara Alpermann, Wolfgang Kern
Publikováno v:
Blood. 116:5486-5496
Mutations in the IDH1 gene at position R132 coding for the enzyme cytosolic isocitrate dehydrogenase are known in glioma and have recently been detected also in acute myeloid leukemia (AML). These mutations result in an accumulation of α-ketoglutara
An in vivo model of double-unit cord blood transplantation that correlates with clinical engraftment
Autor:
Sonali Chaudhury, Richard J. O'Reilly, Lamis Eldjerou, Maria E. Arcila, Glenn Heller, Ada Baisre-de Leon, Malcolm A.S. Moore, Mai He, Juliet N. Barker
Publikováno v:
Blood. 116:3999-4006
Double-unit cord blood transplantation (DCBT) appears to enhance engraftment despite sustained hematopoiesis usually being derived from a single unit. To investigate DCBT biology, in vitro and murine models were established using cells from 39 patien
Autor:
Catherine M Evans, Rosemary E. Gale, Alan Kenneth Burnett, David C. Linch, Claire Green, Robert Kerrin Hills
Publikováno v:
Blood. 116:2779-2782
Mutations in the isocitrate dehydrogenase gene (IDH1) were recently described in patients with acute myeloid leukemia (AML). To investigate their prognostic significance we determined IDH1 status in 1333 young adult patients, excluding acute promyelo
Autor:
Lorena Barclay, Adele Telenius, Merrill Boyle, Christian Steidl, Randy D. Gascoyne, Pedro Farinha, Douglas E. Horsman, Sohrab P. Shah, Joseph M. Connors
Publikováno v:
Blood. 116:418-427
In classical Hodgkin lymphoma (cHL) the mechanisms underlying primary refractory disease and relapse remain unknown. To gain further insight into cHL pathogenesis and genomic changes linked to treatment response, we studied 53 cHL patients by array c