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Autor:
Katherine A. Hajjar, Mary M. Ruisi, Maria T. DeSancho, Neha Kumar, Huigen Chen, Hannah Fassel
Publikováno v:
Blood. 137:2221-2230
Reduced plasma fibrinolysis has been identified as a potential risk factor for venous thromboembolism (VTE), but the role of cell surface fibrinolysis in VTE is unknown. The annexin A2/S100A10 complex serves as a coreceptor for plasminogen and tissue
Autor:
Richard J. Jones, Andrew R. Rezvani, Lawrence E. Morris, Peter Dawson, Joseph P. McGuirk, Eric S. Leifer, John M. Magenau, Paul O'Donnell, Chatchada Karanes, Steven M. Devine, Ephraim J. Fuchs, Mary M. Horowitz, Mary Eapen, Joseph H. Antin, Claudio G. Brunstein, Mitchell E. Horwitz, Brent R. Logan
Publikováno v:
Blood. 137:420-428
Results of two parallel phase II trials of transplantation of unrelated umbilical cord blood or bone marrow from HLA-haploidentical relatives provided equipoise for direct comparison of these donor sources. Between June 2012 and June 2018, 368 patien
Autor:
J. Colton Thompson, Martin S. Tallman, Laurie H. Sehn, Charlotte M. Niemeyer, Nathan A. Pennell, Robert M. Plovnick, Mikkael A. Sekeres, Aaron D Goldberg, Kenneth C. Anderson, Lisa K. Hicks, Donna Neuberg, Emily Tucker, William A. Wood, Kathleen Hewitt
Publikováno v:
Blood Advances
Key Points The ASH Research Collaborative COVID-19 Registry for Hematology collects data on patients with hematologic diseases and COVID-19. Among the first 250 patients, mortality was 28%, and in several patients, a decision was made to forgo intens
Autor:
Joseph P. McGuirk, Ran Reshef, Michael R. Grunwald, Mary Eapen, Natasha Kekre, Rizwan Romee, Ephraim J. Fuchs, Christopher G. Kanakry, Mahasweta Gooptu, Robert J. Soiffer, Claudio G. Brunstein, Nilanjan Ghosh, Mark A. Schroeder, Saurabh Chhabra, Yoshihiro Inamoto, Ian McNiece, Filippo Milano, Dipenkumar Modi, Rohtesh S. Mehta, Monzr M. Al Malki, Joseph H. Antin, Edmund K. Waller, Marco Mielcarek, Andrew St. Martin, Christopher Bredeson, Scott R. Solomon, Mukta Arora
Publikováno v:
Blood
Post transplant cyclophosphamide (PTCy) graft-versus-host disease (GVHD) prophylaxis has allowed haploidentical (Haplo) transplantation to be performed with results similar to that after matched unrelated donor (MUD) transplantation with traditional
Autor:
Vera Dufner, Horst D. Hummel, Ralf C. Bargou, Maria-Elisabeth Goebeler, Cyrus Sayehli, Götz Gelbrich, Manik Chatterjee
Publikováno v:
Blood Advances. 3:2491-2498
Blinatumomab, the first-in-class CD3/CD19 bispecific T-cell engager antibody construct, has recently been approved for treating patients with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia. However, the clinical proof of concept of
Autor:
Pedro Farinha, Joseph M. Connors, Fergus Cafferty, Alina S. Gerrie, David W. Scott, Alden A. Moccia, Ciara L. Freeman, Graham W. Slack, David J. P. Ferguson, Kerry J. Savage, Laurie H. Sehn, Robert Kridel, Brian Skinnider, Diego Villa
Publikováno v:
Blood. 134:761-764
Despite widespread use of bendamustine and rituximab (BR) as frontline therapy for advanced-stage follicular lymphoma (FL), little is known about the risk of early progression or incidence of histological transformation. We performed a retrospective
Autor:
Qian Wu, Mazyar Shadman, Stanley R. Riddell, Utkarsh Acharya, Hans-Peter Kiem, Jordan Gauthier, Sindhu Cherian, Aesha Vakil, Ted Gooley, Jorge Ramos, Alexandre V. Hirayama, Barbara S. Pender, David G. Maloney, Ryan D. Cassaday, Xueyan Chen, Reed M. Hawkins, Gary Schoch, Rachel N. Steinmetz, Daniel Li, Jenna M. Voutsinas, Brian G. Till, Cameron J. Turtle, Aude G. Chapuis, Kevin A. Hay
Publikováno v:
Blood. 133:1652-1663
Autologous T cells engineered to express a CD19-specific chimeric antigen receptor (CAR) have produced impressive minimal residual disease–negative (MRD-negative) complete remission (CR) rates in patients with relapsed/refractory B-cell acute lymph
Autor:
David M. Aboulafia, Erin Reid, Juan Carlos Ramos, Frank Maldarelli, Ronald T. Mitsuyasu, David Looney, Ethel Cesarman, Jeannette Y. Lee, Sara Yahyaei, Ariela Noy, Richard F. Ambinder, David H. Henry, Joseph A. Sparano, William Wachsman
Publikováno v:
Blood Advances. 2:3618-3626
HIV-associated lymphomas (HALs) have high rates of latent infection by gammaherpesviruses (GHVs). We hypothesized that proteasome inhibition would induce lytic activation of GHVs and inhibit HIV infectivity via preservation of cytidine deaminase APOB
Autor:
Philippe Moreau, Laurent Garderet, Bertrand Arnulf, Sabrina Maheo, Lotfi Benboubker, Mamoun Dib, Sabine Brechignac, Nelly Robillard, Mohamad Mohty, Margaret Macro, Brigitte Pegourie, Thierry Facon, Brigitte Kolb, Karim Belhadj, Nikhil C. Munshi, Bruno Royer, Olivier Decaux, Arnaud Jaccard, Valérie Lauwers-Cances, Marie-Lorraine Chretien, Anne-Marie Stoppa, Hervé Avet-Loiseau, Xavier Leleu, Kenneth C. Anderson, Jean-Richard Eveillard, Martin Moorhead, Chantal Doyen, Cecile Fohrer, Lionel Karlin, Jill Corre, Victoria Carlton, Paul G. Richardson, Malek Faham, Jean-Luc Harousseau, Michel Attal, Nathalie Meuleman, Thomas D. Willis, Aurore Perrot, Cyrille Hulin, Thomas Dejoie
Publikováno v:
Blood
Blood, American Society of Hematology, 2018, 132 (23), pp.2456-2464. ⟨10.1182/blood-2018-06-858613⟩
Blood, Vol. 132, no. 23, p. 2456-2464 (2018)
Blood, American Society of Hematology, 2018, 132 (23), pp.2456-2464. ⟨10.1182/blood-2018-06-858613⟩
Blood, Vol. 132, no. 23, p. 2456-2464 (2018)
IF 15.132 (2017); International audience; The introduction of novel agents has led to major improvements in clinical outcomes for patients with multiple myeloma. To shorten evaluation times for new treatments, health agencies are currently examining
Autor:
Sebastian Vogel, Swee Lay Thein, Zenaide M.N. Quezado, James S. Nichols, Taruna Arora, Laurel Mendelsohn, Xunde Wang, Arun S. Shet, Darlene Allen, Christian A. Combs
Publikováno v:
Blood Advances. 2:2672-2680
A key inflammatory mechanism recently identified in platelets involves the Nod-like receptor nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) and Bruton tyrosine kinase (BTK), which control activation of caspase-1 within inf